KIF19_HUMAN
ID KIF19_HUMAN Reviewed; 998 AA.
AC Q2TAC6; A6NLG2; B7ZKR1; Q52M87; Q8N1X8; Q8TAB6;
DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 2.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Kinesin-like protein KIF19;
GN Name=KIF19;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT TRP-471.
RC TISSUE=Amygdala;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), AND NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 1-829 (ISOFORM 1).
RC TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Plus end-directed microtubule-dependent motor protein that
CC regulates the length of motile cilia by mediating depolymerization of
CC microtubules at ciliary tips. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cell
CC projection, cilium {ECO:0000250}. Note=Localizes to cilia tips.
CC {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q2TAC6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q2TAC6-2; Sequence=VSP_023208, VSP_023209;
CC Name=3;
CC IsoId=Q2TAC6-3; Sequence=VSP_023207, VSP_023208, VSP_023209;
CC -!- MISCELLANEOUS: [Isoform 2]: Due to intron retention. {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform 3]: Due to intron retention. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000255|PROSITE-ProRule:PRU00283}.
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DR EMBL; AK094619; BAC04386.1; -; mRNA.
DR EMBL; AC055863; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC103809; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471099; EAW89153.1; -; Genomic_DNA.
DR EMBL; BC093631; AAH93631.1; -; mRNA.
DR EMBL; BC104852; AAI04853.1; -; mRNA.
DR EMBL; BC110989; AAI10990.1; -; mRNA.
DR EMBL; BC143327; AAI43328.1; -; mRNA.
DR CCDS; CCDS32718.2; -. [Q2TAC6-1]
DR RefSeq; NP_694941.2; NM_153209.3. [Q2TAC6-1]
DR AlphaFoldDB; Q2TAC6; -.
DR SMR; Q2TAC6; -.
DR BioGRID; 125878; 5.
DR IntAct; Q2TAC6; 1.
DR MINT; Q2TAC6; -.
DR STRING; 9606.ENSP00000374566; -.
DR iPTMnet; Q2TAC6; -.
DR PhosphoSitePlus; Q2TAC6; -.
DR BioMuta; KIF19; -.
DR DMDM; 126215730; -.
DR EPD; Q2TAC6; -.
DR jPOST; Q2TAC6; -.
DR MassIVE; Q2TAC6; -.
DR MaxQB; Q2TAC6; -.
DR PaxDb; Q2TAC6; -.
DR PeptideAtlas; Q2TAC6; -.
DR PRIDE; Q2TAC6; -.
DR ProteomicsDB; 61459; -. [Q2TAC6-1]
DR ProteomicsDB; 61460; -. [Q2TAC6-2]
DR ProteomicsDB; 61461; -. [Q2TAC6-3]
DR Antibodypedia; 31955; 88 antibodies from 20 providers.
DR DNASU; 124602; -.
DR Ensembl; ENST00000389916.5; ENSP00000374566.4; ENSG00000196169.15. [Q2TAC6-1]
DR GeneID; 124602; -.
DR KEGG; hsa:124602; -.
DR MANE-Select; ENST00000389916.5; ENSP00000374566.4; NM_153209.4; NP_694941.2.
DR UCSC; uc002jkm.4; human. [Q2TAC6-1]
DR CTD; 124602; -.
DR GeneCards; KIF19; -.
DR HGNC; HGNC:26735; KIF19.
DR HPA; ENSG00000196169; Tissue enhanced (brain, fallopian tube, lymphoid tissue).
DR MIM; 619610; gene.
DR neXtProt; NX_Q2TAC6; -.
DR OpenTargets; ENSG00000196169; -.
DR PharmGKB; PA143485523; -.
DR VEuPathDB; HostDB:ENSG00000196169; -.
DR eggNOG; KOG0242; Eukaryota.
DR GeneTree; ENSGT00940000160989; -.
DR HOGENOM; CLU_001485_15_0_1; -.
DR InParanoid; Q2TAC6; -.
DR OMA; QGRLFMV; -.
DR OrthoDB; 488751at2759; -.
DR PhylomeDB; Q2TAC6; -.
DR TreeFam; TF331721; -.
DR PathwayCommons; Q2TAC6; -.
DR Reactome; R-HSA-6811434; COPI-dependent Golgi-to-ER retrograde traffic.
DR Reactome; R-HSA-983189; Kinesins.
DR SignaLink; Q2TAC6; -.
DR BioGRID-ORCS; 124602; 12 hits in 1073 CRISPR screens.
DR ChiTaRS; KIF19; human.
DR GenomeRNAi; 124602; -.
DR Pharos; Q2TAC6; Tbio.
DR PRO; PR:Q2TAC6; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q2TAC6; protein.
DR Bgee; ENSG00000196169; Expressed in right uterine tube and 95 other tissues.
DR ExpressionAtlas; Q2TAC6; baseline and differential.
DR GO; GO:0005930; C:axoneme; IEA:GOC.
DR GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR GO; GO:0005871; C:kinesin complex; IBA:GO_Central.
DR GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0003777; F:microtubule motor activity; IBA:GO_Central.
DR GO; GO:0008574; F:plus-end-directed microtubule motor activity; ISS:UniProtKB.
DR GO; GO:0060404; P:axonemal microtubule depolymerization; ISS:UniProtKB.
DR GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central.
DR GO; GO:0070462; P:plus-end specific microtubule depolymerization; ISS:UniProtKB.
DR Gene3D; 3.40.850.10; -; 1.
DR InterPro; IPR027640; Kinesin-like_fam.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24115; PTHR24115; 1.
DR Pfam; PF00225; Kinesin; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; ATP-binding; Cell projection; Cilium; Coiled coil;
KW Cytoplasm; Cytoskeleton; Microtubule; Motor protein; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..998
FT /note="Kinesin-like protein KIF19"
FT /id="PRO_0000278245"
FT DOMAIN 11..346
FT /note="Kinesin motor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00283"
FT REGION 482..503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 662..706
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 746..765
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 794..911
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 948..998
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 360..391
FT /evidence="ECO:0000255"
FT COILED 424..452
FT /evidence="ECO:0000255"
FT COILED 507..552
FT /evidence="ECO:0000255"
FT COMPBIAS 482..498
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 662..702
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 746..762
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 838..854
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 874..896
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 104..111
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00283"
FT VAR_SEQ 152..193
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_023207"
FT VAR_SEQ 530..548
FT /note="LALEQRCRELRARGRRLEE -> VSRVWGDKESGFRGQGEQV (in
FT isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_023208"
FT VAR_SEQ 549..998
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_023209"
FT VARIANT 471
FT /note="R -> W (in dbSNP:rs2382644)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_030719"
FT VARIANT 807
FT /note="R -> H (in dbSNP:rs2271535)"
FT /id="VAR_059371"
FT VARIANT 937
FT /note="L -> P (in dbSNP:rs9891620)"
FT /id="VAR_049703"
FT VARIANT 974
FT /note="R -> Q (in dbSNP:rs9675190)"
FT /id="VAR_061283"
SQ SEQUENCE 998 AA; 111332 MW; 7E42AB992F038E53 CRC64;
MKDSGDSKDQ QLMVALRVRP ISVAELEEGA TLIAHKVDEQ MVVLMDPMED PDDILRAHRS
REKSYLFDVA FDFTATQEMV YQATTKSLIE GVISGYNATV FAYGPTGCGK TYTMLGTDQE
PGIYVQTLND LFRAIEETSN DMEYEVSMSY LEIYNEMIRD LLNPSLGYLE LREDSKGVIQ
VAGITEVSTI NAKEIMQLLM KGNRQRTQEP TAANQTSSRS HAVLQVTVRQ RSRVKNILQE
VRQGRLFMID LAGSERASQT QNRGQRMKEG AHINRSLLAL GNCINALSDK GSNKYINYRD
SKLTRLLKDS LGGNSRTVMI AHISPASSAF EESRNTLTYA GRAKNIKTRV KQNLLNVSYH
IAQYTSIIAD LRGEIQRLKR KIDEQTGRGQ ARGRQDRGDI RHIQAEVQLH SGQGEKAGMG
QLREQLASAF QEQMDVRRRL LELENRAMEV QIDTSRHLLT IAGWKHEKSR RALKWREEQR
KECYAKDDSE KDSDTGDDQP DILEPPEVAA ARESIAALVD EQKQLRKQKL ALEQRCRELR
ARGRRLEETL PRRIGSEEQR EVLSLLCRVH ELEVENTEMQ SHALLRDGAL RHRHEAVRRL
EQHRSLCDEI IQGQRQIIDD YNLAVPQRLE ELYEVYLREL EEGSLEQATI MDQVASRALQ
DSSLPKITPA GTSLTPDSDL ESVKTLSSDA QHLQNSALPP LSTESEGHHV FKAGTGAWQA
KSSSVPTPPP IQLGSLVTQE APAQDSLGSW INSSPDSSEN LSEIPLSHKE RKEILTGTKC
IWVKAARRRS RALGTEGRHL LAPATERSSL SLHSLSEGDD ARPPGPLACK RPPSPTLQHA
ASEDNLSSST GEAPSRAVGH HGDGPRPWLR GQKKSLGKKR EESLEAKRRK RRSRSFEVTG
QGLSHPKTHL LGPHQAERIS DHRMPVCRHP APGIRHLGKV TLPLAKVKLP PSQNTGPGDS
SPLAVPPNPG GGSRRATRGP RLPHGTSTHG KDGCSRHN
