ID   KIF1A_ANOGA             Reviewed;        1644 AA.
AC   Q7PHR1;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 3.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Kinesin-like protein unc-104;
GN   Name=unc-104 {ECO:0000250|UniProtKB:A1ZAJ2}; ORFNames=AGAP010519;
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7165;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST;
RX   PubMed=12364791; DOI=10.1126/science.1076181;
RA   Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA   Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA   Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA   Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA   Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA   Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA   Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA   Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA   Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA   Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA   Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA   Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA   McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA   O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA   Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA   Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA   Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA   Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA   Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA   Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA   Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA   Collins F.H., Hoffman S.L.;
RT   "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL   Science 298:129-149(2002).
CC   -!- FUNCTION: Required for presynaptic maturation, has a role in axonal
CC       transport of dense-core vesicles carrying synaptic vesicle precursors,
CC       components required for the morphological transformation of axonal
CC       growth cones to mature boutons. {ECO:0000250|UniProtKB:A1ZAJ2}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250|UniProtKB:Q60575}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000250|UniProtKB:A1ZAJ2}. Note=Microtubule-associated.
CC       {ECO:0000250|UniProtKB:A1ZAJ2}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC       superfamily. Kinesin family. Unc-104 subfamily. {ECO:0000255|PROSITE-
CC       ProRule:PRU00283}.
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DR   EMBL; AAAB01008933; EAA44439.3; -; Genomic_DNA.
DR   RefSeq; XP_314493.3; XM_314493.4.
DR   AlphaFoldDB; Q7PHR1; -.
DR   SMR; Q7PHR1; -.
DR   STRING; 7165.AGAP010519-PC; -.
DR   PaxDb; Q7PHR1; -.
DR   GeneID; 1275256; -.
DR   KEGG; aga:AgaP_AGAP010519; -.
DR   CTD; 1275256; -.
DR   VEuPathDB; VectorBase:AGAP010519; -.
DR   eggNOG; KOG0245; Eukaryota.
DR   HOGENOM; CLU_001485_10_0_1; -.
DR   InParanoid; Q7PHR1; -.
DR   OrthoDB; 76316at2759; -.
DR   PhylomeDB; Q7PHR1; -.
DR   Proteomes; UP000007062; Chromosome 3L.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005871; C:kinesin complex; IBA:GO_Central.
DR   GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR   GO; GO:0005875; C:microtubule associated complex; ISS:UniProtKB.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR   GO; GO:0003777; F:microtubule motor activity; IBA:GO_Central.
DR   GO; GO:0008574; F:plus-end-directed microtubule motor activity; IBA:GO_Central.
DR   GO; GO:0030705; P:cytoskeleton-dependent intracellular transport; IBA:GO_Central.
DR   GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central.
DR   GO; GO:0048489; P:synaptic vesicle transport; ISS:UniProtKB.
DR   GO; GO:0047496; P:vesicle transport along microtubule; ISS:UniProtKB.
DR   GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR   CDD; cd00060; FHA; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   Gene3D; 3.40.850.10; -; 1.
DR   InterPro; IPR000253; FHA_dom.
DR   InterPro; IPR022164; Kinesin-like.
DR   InterPro; IPR027640; Kinesin-like_fam.
DR   InterPro; IPR022140; Kinesin-like_KIF1-typ.
DR   InterPro; IPR032405; Kinesin_assoc.
DR   InterPro; IPR019821; Kinesin_motor_CS.
DR   InterPro; IPR001752; Kinesin_motor_dom.
DR   InterPro; IPR036961; Kinesin_motor_dom_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR008984; SMAD_FHA_dom_sf.
DR   PANTHER; PTHR24115; PTHR24115; 3.
DR   Pfam; PF12473; DUF3694; 1.
DR   Pfam; PF00498; FHA; 1.
DR   Pfam; PF12423; KIF1B; 1.
DR   Pfam; PF00225; Kinesin; 1.
DR   Pfam; PF16183; Kinesin_assoc; 2.
DR   Pfam; PF00169; PH; 1.
DR   PRINTS; PR00380; KINESINHEAVY.
DR   SMART; SM00240; FHA; 1.
DR   SMART; SM00129; KISc; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF49879; SSF49879; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR   PROSITE; PS50067; KINESIN_MOTOR_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Coiled coil; Cytoplasm; Cytoskeleton; Microtubule;
KW   Motor protein; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..1644
FT                   /note="Kinesin-like protein unc-104"
FT                   /id="PRO_0000299495"
FT   DOMAIN          3..351
FT                   /note="Kinesin motor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00283"
FT   DOMAIN          497..563
FT                   /note="FHA"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          1542..1640
FT                   /note="PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   REGION          391..412
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          952..984
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          358..434
FT                   /evidence="ECO:0000255"
FT   COILED          611..670
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        967..983
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         97..104
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00283"
SQ   SEQUENCE   1644 AA;  185650 MW;  8E5EEB528BC0B1DD CRC64;
     MSSVKVAVRV RPFNSREIAR ESKCIIEMAG NTTCITNPKV PPGSSESVKR FNYDYSYWSH
     DPRDLEFSTQ AMVYSDIGEE MLQHSFDGYN VCIFAYGQTG AGKSYTMMGK QEDGQEGVIP
     MICKDLFRRI QETESDDLKY SVEVSYMEIY CERVRDLLNP KNKGNLKVRE HPLLGPYVED
     LSKLAVTSYQ DIHDLIDEGN KARTVAATNM NETSSRSHAV FTIFFTQKRQ DRMTSLETEK
     VSKISLVDLA GSERADSTGA KGTRLKEGAN INKSLTTLGK VISALAEIAS KNKKSKKADF
     IPYRDSVLTW LLRENLGGNS KTAMIAAISP ADINYDETLS TLRYADRAKQ IVCKAVVNED
     ANAKLIRELK EEIQKLRELL KAEGIEVQEG EDGEKKIHSP NRNRKRTGSS TEMAVDQLQA
     SEKLIAELNE TWEEKLKRTE QIRVQREAVF AEMGVAVKED GITVGVFSPK KSPHLVNLNE
     DPTLSECLLY YIKDGLTRLG TSEANVPQDI QLSGSHILKE HCVFENKDGV VTLVPHKDAL
     VYVNGRKVIE PEVLQTGSRV ILGRNHVFRF THPEQAREKR EKNKEVDVCE TPGNSGEIAD
     WNFAQCELLE KQGIDLKAEM EKRLLALEEQ YKREKRAADQ EFEEQRKTYE ARIDALQKQV
     EEQSMTMSMY SSYSPEDFHQ EEDIFVNPLF ESCWTAREAG LAAWAFRKWR YHQFTSLRDD
     LWGNAIFLKE ANAISVELKK KVQFQFTLLT DTLYSPLPPE LTPAPAVGAL TNGGQEDEFG
     QNPIPRTTVA VEVTDTKNGA THYWSLEKLR QRLELMREMY HNEAELSPTS PDYNVESLTG
     GDPFYDRFPW FRMVGRSFVY LSNLLYPVPL VHKVAIVNER GDVRGYLRVA VQPVMDEENA
     DFSNGVKQSA RILFDEEQNG QHKVPKIRTI PDKDEKYIEG GNEMGTKLEE LEQEDADSGR
     GDSSVASELH ESNDQEPGEH LQPGKEFTFR VTVLQATGIA AEYADIFCQF NFLHRHEEAF
     STEPVKNSGS GAPLGFYHVQ NITVPVTKSF IEYLKTQPIV FKVFGHYQHH PLHKDAKQDC
     QITRPPPRRM LPPSIPISQP VRSPKFGPLP CPPSSTVLAK HDVLVWFEIC ELAPNGEYVP
     AVVDHSDDLP CRGLFLLHQG IQRRIRITIV HEPTPEVKWK DIRELVVGRI RNQPEPADDE
     DSDSCVLSLG LFPGEVLEVP GDDRSFFRFE AAWDSSLHNS ALLNRVTQTG EQIYITLSAY
     LELDNCARPA IITKDLSMII YGRDARTGPR SLKHLFSGQY RNPEANRLSG VYELSLRRAS
     EAGSPGVQRR QRRVLDTSST YVRGEENLHG WRPRGDSLIF DHQWELEKLT RLEEVGRVRH
     LLLLRERLGM DTTPNPTTKT EKDVCNLAQR ASASPVHMVI PPSPQTPVKD QQAPAMPERE
     LSVRETELVW KCVKLIQGRI GCKELGAEGN GSGTQASDAS PGDEGCADMN ASYISSNSIE
     LCSPERVDMP NGWEAPAPAP QTQDLSLRLY VPELEEIRVS PVVARKGYLN VLEHGGSGWK
     KRWVTVRRPY VFIFRSDKDP VERAVLNLAT AQVECSEDQA AMVKVPNTFS VVTKHRGYLL
     QTLGDKEVHD WLYAINPLLA GQIR