KIF1B_HUMAN
ID KIF1B_HUMAN Reviewed; 1816 AA.
AC O60333; A6NFS8; A6NKQ4; Q4VXC3; Q4VXC4; Q4VXC5; Q4VXC6; Q96Q94; Q9BV80;
AC Q9P280;
DT 11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 5.
DT 03-AUG-2022, entry version 222.
DE RecName: Full=Kinesin-like protein KIF1B;
DE Short=Klp;
GN Name=KIF1B; Synonyms=KIAA0591, KIAA1448;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
RA Bougueleret L., Dufaure-Gare I., Grel P.;
RT "DNA encoding a kinesin-like protein (hklp) comprising biallelic markers.";
RL Patent number WO0063375, 26-OCT-2000.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), AND TISSUE SPECIFICITY.
RC TISSUE=Substantia nigra;
RX PubMed=10762626; DOI=10.3892/ijo.16.5.907;
RA Nagai M., Ichimiya S., Ozaki T., Seki N., Mihara M., Furuta S., Ohira M.,
RA Tomioka N., Nomura N., Sakiyama S., Kubo O., Takakura K., Hori T.,
RA Nakagawara A.;
RT "Identification of the full-length KIAA0591 gene encoding a novel kinesin-
RT related protein which is mapped to the neuroblastoma suppressor gene locus
RT at 1p36.2.";
RL Int. J. Oncol. 16:907-916(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2), AND TISSUE SPECIFICITY.
RX PubMed=11526494; DOI=10.1038/sj.onc.1204456;
RA Yang H.W., Chen Y.Z., Takita J., Soeda E., Piao H.Y., Hayashi Y.;
RT "Genomic structure and mutational analysis of the human KIF1B gene which is
RT homozygously deleted in neuroblastoma at chromosome 1p36.2.";
RL Oncogene 20:5075-5083(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
RA Park M., Shin H., Lee Y.M., Moon E., Choi W., Kim W.;
RT "Identification of the human ortholog of mouse Kif1B, a kinesin superfamily
RT motor protein.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
RA Munirajan A.K., Ohira M., Nakagawara A.;
RT "Identification of splicing variants of KIF1Bbeta.";
RL Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), AND TISSUE SPECIFICITY.
RC TISSUE=Neuroblastoma;
RX PubMed=12888911;
RA Chen Y.Y., Takita J., Chen Y.Z., Yang H.W., Hanada R., Yamamoto K.,
RA Hayashi Y.;
RT "Genomic structure and mutational analysis of the human KIF1Balpha gene
RT located at 1p36.2 in neuroblastoma.";
RL Int. J. Oncol. 23:737-744(2003).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=9628581; DOI=10.1093/dnares/5.1.31;
RA Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N.,
RA Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. IX. The
RT complete sequences of 100 new cDNA clones from brain which can code for
RT large proteins in vitro.";
RL DNA Res. 5:31-39(1998).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Brain;
RX PubMed=10819331; DOI=10.1093/dnares/7.2.143;
RA Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XVII. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 7:143-150(2000).
RN [9]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [10]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 1238-1816 (ISOFORMS 1/2).
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [11]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1238-1816 (ISOFORMS 1/2).
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [12]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1449-1816 (ISOFORMS 1/2).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [13]
RP INTERACTION WITH KIFBP, AND SUBCELLULAR LOCATION.
RX PubMed=16225668; DOI=10.1186/1471-2121-6-35;
RA Wozniak M.J., Melzer M., Dorner C., Haring H.U., Lammers R.;
RT "The novel protein KBP regulates mitochondria localization by interaction
RT with a kinesin-like protein.";
RL BMC Cell Biol. 6:35-35(2005).
RN [14]
RP FUNCTION, INVOLVEMENT IN NEUROBLASTOMA AND PHEOCHROMOCYTOMA, AND VARIANTS
RP LEU-34; VAL-692; ILE-873; CYS-1133; SER-1263; ASN-1527; MET-1600 AND
RP LYS-1674.
RX PubMed=18334619; DOI=10.1101/gad.1648608;
RA Schlisio S., Kenchappa R.S., Vredeveld L.C., George R.E., Stewart R.,
RA Greulich H., Shahriari K., Nguyen N.V., Pigny P., Dahia P.L., Pomeroy S.L.,
RA Maris J.M., Look A.T., Meyerson M., Peeper D.S., Carter B.D.,
RA Kaelin W.G. Jr.;
RT "The kinesin KIF1Bbeta acts downstream from EglN3 to induce apoptosis and
RT is a potential 1p36 tumor suppressor.";
RL Genes Dev. 22:884-893(2008).
RN [15]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1057, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [16]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [17]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1075 AND SER-1487, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [18]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1057; SER-1454; SER-1487;
RP SER-1610 AND SER-1613, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1141
RP (ISOFORM 3), AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
RP ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [19]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [20]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-663 AND SER-665 (ISOFORM 3),
RP AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [21]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, CLEAVAGE OF INITIATOR
RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN [22]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1054; SER-1057; SER-1416;
RP SER-1454 AND SER-1487, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
RP ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [23]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1454; SER-1573; SER-1603 AND
RP SER-1613, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-665 (ISOFORM 3),
RP AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [24]
RP VARIANT CMT2A1 LEU-98.
RX PubMed=11389829; DOI=10.1016/s0092-8674(01)00363-4;
RA Zhao C., Takita J., Tanaka Y., Setou M., Nakagawa T., Takeda S., Yang H.W.,
RA Terada S., Nakata T., Takei Y., Saito M., Tsuji S., Hayashi Y.,
RA Hirokawa N.;
RT "Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule
RT motor KIF1B-beta.";
RL Cell 105:587-597(2001).
CC -!- FUNCTION: Motor for anterograde transport of mitochondria. Has a
CC microtubule plus end-directed motility. Isoform 2 is required for
CC induction of neuronal apoptosis. {ECO:0000269|PubMed:18334619}.
CC -!- FUNCTION: Isoform 1 mediates the transport of synaptic vesicles in
CC neuronal cells. {ECO:0000250|UniProtKB:O88658}.
CC -!- SUBUNIT: Monomer (By similarity). Interacts (via C-terminus end of the
CC kinesin-motor domain) with CHP1; the interaction occurs in a calcium-
CC dependent manner (By similarity). Interacts with KIFBP
CC (PubMed:16225668). Interacts with MADD (via death domain) (By
CC similarity). {ECO:0000250|UniProtKB:O88658,
CC ECO:0000250|UniProtKB:Q60575, ECO:0000269|PubMed:16225668}.
CC -!- INTERACTION:
CC O60333; Q7Z460: CLASP1; NbExp=3; IntAct=EBI-465633, EBI-913476;
CC O60333; Q8IUQ4: SIAH1; NbExp=3; IntAct=EBI-465633, EBI-747107;
CC O60333-2; Q6UY14-3: ADAMTSL4; NbExp=3; IntAct=EBI-10975473, EBI-10173507;
CC O60333-2; P20933: AGA; NbExp=3; IntAct=EBI-10975473, EBI-1223922;
CC O60333-2; Q6ZTN6-2: ANKRD13D; NbExp=3; IntAct=EBI-10975473, EBI-25840993;
CC O60333-2; Q92688: ANP32B; NbExp=3; IntAct=EBI-10975473, EBI-762428;
CC O60333-2; P13928: ANXA8; NbExp=3; IntAct=EBI-10975473, EBI-2556915;
CC O60333-2; D3DTF8: APLN; NbExp=3; IntAct=EBI-10975473, EBI-22002556;
CC O60333-2; P05067: APP; NbExp=3; IntAct=EBI-10975473, EBI-77613;
CC O60333-2; O94778: AQP8; NbExp=3; IntAct=EBI-10975473, EBI-19124986;
CC O60333-2; Q86TN1: ARNT2; NbExp=3; IntAct=EBI-10975473, EBI-25844820;
CC O60333-2; Q9Y575-3: ASB3; NbExp=3; IntAct=EBI-10975473, EBI-14199987;
CC O60333-2; Q96DX5: ASB9; NbExp=3; IntAct=EBI-10975473, EBI-745641;
CC O60333-2; Q96DX5-3: ASB9; NbExp=3; IntAct=EBI-10975473, EBI-25843552;
CC O60333-2; Q6XD76: ASCL4; NbExp=3; IntAct=EBI-10975473, EBI-10254793;
CC O60333-2; Q96FT7-4: ASIC4; NbExp=3; IntAct=EBI-10975473, EBI-9089489;
CC O60333-2; Q9H0Y0: ATG10; NbExp=3; IntAct=EBI-10975473, EBI-1048913;
CC O60333-2; P15313: ATP6V1B1; NbExp=3; IntAct=EBI-10975473, EBI-2891281;
CC O60333-2; P46379-2: BAG6; NbExp=3; IntAct=EBI-10975473, EBI-10988864;
CC O60333-2; Q9UQB8-6: BAIAP2; NbExp=3; IntAct=EBI-10975473, EBI-9092016;
CC O60333-2; Q16611: BAK1; NbExp=3; IntAct=EBI-10975473, EBI-519866;
CC O60333-2; Q8IXM2: BAP18; NbExp=3; IntAct=EBI-10975473, EBI-4280811;
CC O60333-2; Q16520: BATF; NbExp=3; IntAct=EBI-10975473, EBI-749503;
CC O60333-2; Q9BXK5: BCL2L13; NbExp=3; IntAct=EBI-10975473, EBI-747430;
CC O60333-2; Q14457: BECN1; NbExp=3; IntAct=EBI-10975473, EBI-949378;
CC O60333-2; Q96LC9: BMF; NbExp=3; IntAct=EBI-10975473, EBI-3919268;
CC O60333-2; Q8WUW1: BRK1; NbExp=3; IntAct=EBI-10975473, EBI-2837444;
CC O60333-2; Q0VDD7: BRME1; NbExp=3; IntAct=EBI-10975473, EBI-741210;
CC O60333-2; Q9NSI6-4: BRWD1; NbExp=3; IntAct=EBI-10975473, EBI-10693038;
CC O60333-2; Q9H0W9-4: C11orf54; NbExp=3; IntAct=EBI-10975473, EBI-25849710;
CC O60333-2; Q8TAB5: C1orf216; NbExp=3; IntAct=EBI-10975473, EBI-747505;
CC O60333-2; Q8N865: C7orf31; NbExp=3; IntAct=EBI-10975473, EBI-10174456;
CC O60333-2; Q96LL4: C8orf48; NbExp=3; IntAct=EBI-10975473, EBI-751596;
CC O60333-2; Q96NX5: CAMK1G; NbExp=3; IntAct=EBI-10975473, EBI-3920838;
CC O60333-2; Q8N5S9-2: CAMKK1; NbExp=3; IntAct=EBI-10975473, EBI-25850646;
CC O60333-2; Q6ZP82: CCDC141; NbExp=3; IntAct=EBI-10975473, EBI-928795;
CC O60333-2; Q96LX7-5: CCDC17; NbExp=3; IntAct=EBI-10975473, EBI-12165781;
CC O60333-2; A0A1B0GWI1: CCDC196; NbExp=3; IntAct=EBI-10975473, EBI-10181422;
CC O60333-2; Q9Y3X0: CCDC9; NbExp=3; IntAct=EBI-10975473, EBI-2557532;
CC O60333-2; Q9UJX2: CDC23; NbExp=3; IntAct=EBI-10975473, EBI-396137;
CC O60333-2; Q494V2-2: CFAP100; NbExp=3; IntAct=EBI-10975473, EBI-11953200;
CC O60333-2; Q9Y3D0: CIAO2B; NbExp=3; IntAct=EBI-10975473, EBI-744045;
CC O60333-2; Q14677: CLINT1; NbExp=3; IntAct=EBI-10975473, EBI-1171113;
CC O60333-2; Q96DZ5: CLIP3; NbExp=3; IntAct=EBI-10975473, EBI-12823145;
CC O60333-2; Q6PJW8-3: CNST; NbExp=3; IntAct=EBI-10975473, EBI-25836090;
CC O60333-2; Q96MW5: COG8; NbExp=3; IntAct=EBI-10975473, EBI-720875;
CC O60333-2; Q8IUI8: CRLF3; NbExp=3; IntAct=EBI-10975473, EBI-2872414;
CC O60333-2; P02489: CRYAA; NbExp=3; IntAct=EBI-10975473, EBI-6875961;
CC O60333-2; Q8TB03: CXorf38; NbExp=3; IntAct=EBI-10975473, EBI-12024320;
CC O60333-2; P00167: CYB5A; NbExp=3; IntAct=EBI-10975473, EBI-1047284;
CC O60333-2; Q7L576: CYFIP1; NbExp=3; IntAct=EBI-10975473, EBI-1048143;
CC O60333-2; Q5TAQ9-2: DCAF8; NbExp=3; IntAct=EBI-10975473, EBI-25842815;
CC O60333-2; Q8NDP9: DKFZp547K2416; NbExp=3; IntAct=EBI-10975473, EBI-25842538;
CC O60333-2; Q9P1A6-3: DLGAP2; NbExp=3; IntAct=EBI-10975473, EBI-12019838;
CC O60333-2; Q5VZB9: DMRTA1; NbExp=3; IntAct=EBI-10975473, EBI-3939812;
CC O60333-2; Q7L591-3: DOK3; NbExp=3; IntAct=EBI-10975473, EBI-10694655;
CC O60333-2; A0A024RCP2: DOM3Z; NbExp=3; IntAct=EBI-10975473, EBI-25847826;
CC O60333-2; O14531: DPYSL4; NbExp=3; IntAct=EBI-10975473, EBI-719542;
CC O60333-2; Q9BPU6: DPYSL5; NbExp=3; IntAct=EBI-10975473, EBI-724653;
CC O60333-2; Q92997: DVL3; NbExp=3; IntAct=EBI-10975473, EBI-739789;
CC O60333-2; O75530-2: EED; NbExp=3; IntAct=EBI-10975473, EBI-11132357;
CC O60333-2; O00303: EIF3F; NbExp=3; IntAct=EBI-10975473, EBI-711990;
CC O60333-2; Q9H6S3: EPS8L2; NbExp=3; IntAct=EBI-10975473, EBI-3940939;
CC O60333-2; Q13216-2: ERCC8; NbExp=3; IntAct=EBI-10975473, EBI-16466949;
CC O60333-2; Q9NQ30: ESM1; NbExp=3; IntAct=EBI-10975473, EBI-12260294;
CC O60333-2; Q6NXG1: ESRP1; NbExp=3; IntAct=EBI-10975473, EBI-10213520;
CC O60333-2; Q99504: EYA3; NbExp=3; IntAct=EBI-10975473, EBI-9089567;
CC O60333-2; O15540: FABP7; NbExp=3; IntAct=EBI-10975473, EBI-10697159;
CC O60333-2; Q6P1L5: FAM117B; NbExp=3; IntAct=EBI-10975473, EBI-3893327;
CC O60333-2; Q49AJ0-4: FAM135B; NbExp=3; IntAct=EBI-10975473, EBI-25835236;
CC O60333-2; Q96GL9: FAM163A; NbExp=3; IntAct=EBI-10975473, EBI-11793142;
CC O60333-2; Q17RN3: FAM98C; NbExp=3; IntAct=EBI-10975473, EBI-5461838;
CC O60333-2; Q8IZU1: FAM9A; NbExp=3; IntAct=EBI-10975473, EBI-8468186;
CC O60333-2; O15287: FANCG; NbExp=3; IntAct=EBI-10975473, EBI-81610;
CC O60333-2; Q8TC84: FANK1; NbExp=3; IntAct=EBI-10975473, EBI-21975404;
CC O60333-2; Q53R41: FASTKD1; NbExp=3; IntAct=EBI-10975473, EBI-3957005;
CC O60333-2; O00757: FBP2; NbExp=3; IntAct=EBI-10975473, EBI-719781;
CC O60333-2; Q9UHY8: FEZ2; NbExp=3; IntAct=EBI-10975473, EBI-396453;
CC O60333-2; P15407: FOSL1; NbExp=3; IntAct=EBI-10975473, EBI-744510;
CC O60333-2; Q8NCL4: GALNT6; NbExp=3; IntAct=EBI-10975473, EBI-3907241;
CC O60333-2; P15976-2: GATA1; NbExp=3; IntAct=EBI-10975473, EBI-9090198;
CC O60333-2; Q9NXC2: GFOD1; NbExp=3; IntAct=EBI-10975473, EBI-8799578;
CC O60333-2; P10075: GLI4; NbExp=3; IntAct=EBI-10975473, EBI-14061927;
CC O60333-2; Q9HBQ8: GOLGA2P5; NbExp=3; IntAct=EBI-10975473, EBI-22000587;
CC O60333-2; O95872: GPANK1; NbExp=3; IntAct=EBI-10975473, EBI-751540;
CC O60333-2; Q7Z602: GPR141; NbExp=3; IntAct=EBI-10975473, EBI-21649723;
CC O60333-2; Q9Y4H4: GPSM3; NbExp=3; IntAct=EBI-10975473, EBI-347538;
CC O60333-2; Q6NXT2: H3-5; NbExp=3; IntAct=EBI-10975473, EBI-2868501;
CC O60333-2; A8K0U2: hCG_2001421; NbExp=3; IntAct=EBI-10975473, EBI-25843825;
CC O60333-2; A0A024R1L7: hCG_41307; NbExp=3; IntAct=EBI-10975473, EBI-25849938;
CC O60333-2; P49639: HOXA1; NbExp=3; IntAct=EBI-10975473, EBI-740785;
CC O60333-2; P09017: HOXC4; NbExp=3; IntAct=EBI-10975473, EBI-3923226;
CC O60333-2; Q96EW2-2: HSPBAP1; NbExp=3; IntAct=EBI-10975473, EBI-25835621;
CC O60333-2; Q8IY31-3: IFT20; NbExp=3; IntAct=EBI-10975473, EBI-9091197;
CC O60333-2; P22692: IGFBP4; NbExp=3; IntAct=EBI-10975473, EBI-2831948;
CC O60333-2; Q14005-2: IL16; NbExp=3; IntAct=EBI-10975473, EBI-17178971;
CC O60333-2; Q9NXX0: ILF3; NbExp=3; IntAct=EBI-10975473, EBI-743980;
CC O60333-2; Q8WYH8-2: ING5; NbExp=3; IntAct=EBI-10975473, EBI-21602071;
CC O60333-2; Q8IXL9: IQCF2; NbExp=3; IntAct=EBI-10975473, EBI-10238842;
CC O60333-2; Q8NA54: IQUB; NbExp=3; IntAct=EBI-10975473, EBI-10220600;
CC O60333-2; Q86U28: ISCA2; NbExp=3; IntAct=EBI-10975473, EBI-10258659;
CC O60333-2; Q9UKP3-2: ITGB1BP2; NbExp=3; IntAct=EBI-10975473, EBI-25856470;
CC O60333-2; P0C870: JMJD7; NbExp=3; IntAct=EBI-10975473, EBI-9090173;
CC O60333-2; Q9NVX7-2: KBTBD4; NbExp=3; IntAct=EBI-10975473, EBI-25871195;
CC O60333-2; Q8WZ19: KCTD13; NbExp=3; IntAct=EBI-10975473, EBI-742916;
CC O60333-2; Q96SI1-2: KCTD15; NbExp=3; IntAct=EBI-10975473, EBI-12382297;
CC O60333-2; Q06136: KDSR; NbExp=3; IntAct=EBI-10975473, EBI-3909166;
CC O60333-2; Q6ZU52: KIAA0408; NbExp=3; IntAct=EBI-10975473, EBI-739493;
CC O60333-2; Q12756: KIF1A; NbExp=3; IntAct=EBI-10975473, EBI-2679809;
CC O60333-2; Q9UIH9: KLF15; NbExp=3; IntAct=EBI-10975473, EBI-2796400;
CC O60333-2; P57682: KLF3; NbExp=3; IntAct=EBI-10975473, EBI-8472267;
CC O60333-2; Q9Y2M5: KLHL20; NbExp=3; IntAct=EBI-10975473, EBI-714379;
CC O60333-2; Q8N1A0: KRT222; NbExp=3; IntAct=EBI-10975473, EBI-8473062;
CC O60333-2; Q14525: KRT33B; NbExp=3; IntAct=EBI-10975473, EBI-1049638;
CC O60333-2; Q3SY46: KRTAP13-3; NbExp=3; IntAct=EBI-10975473, EBI-10241252;
CC O60333-2; Q3SYF9: KRTAP19-7; NbExp=3; IntAct=EBI-10975473, EBI-10241353;
CC O60333-2; Q8IUC2: KRTAP8-1; NbExp=3; IntAct=EBI-10975473, EBI-10261141;
CC O60333-2; Q14847-2: LASP1; NbExp=3; IntAct=EBI-10975473, EBI-9088686;
CC O60333-2; O95447: LCA5L; NbExp=3; IntAct=EBI-10975473, EBI-8473670;
CC O60333-2; Q5T7P3: LCE1B; NbExp=3; IntAct=EBI-10975473, EBI-10245913;
CC O60333-2; Q96PV6: LENG8; NbExp=3; IntAct=EBI-10975473, EBI-739546;
CC O60333-2; Q68G74: LHX8; NbExp=3; IntAct=EBI-10975473, EBI-8474075;
CC O60333-2; Q8N448: LNX2; NbExp=3; IntAct=EBI-10975473, EBI-2340947;
CC O60333-2; A2RU56: LOC401296; NbExp=3; IntAct=EBI-10975473, EBI-9088215;
CC O60333-2; Q96JB6: LOXL4; NbExp=3; IntAct=EBI-10975473, EBI-749562;
CC O60333-2; Q14693: LPIN1; NbExp=3; IntAct=EBI-10975473, EBI-5278370;
CC O60333-2; Q9UDY8-2: MALT1; NbExp=3; IntAct=EBI-10975473, EBI-12056869;
CC O60333-2; Q99683: MAP3K5; NbExp=3; IntAct=EBI-10975473, EBI-476263;
CC O60333-2; P61244-4: MAX; NbExp=3; IntAct=EBI-10975473, EBI-25848049;
CC O60333-2; Q9NS73-5: MBIP; NbExp=3; IntAct=EBI-10975473, EBI-10182361;
CC O60333-2; Q03112-9: MECOM; NbExp=3; IntAct=EBI-10975473, EBI-23820194;
CC O60333-2; Q8N6F8: METTL27; NbExp=3; IntAct=EBI-10975473, EBI-8487781;
CC O60333-2; Q9NYP9: MIS18A; NbExp=3; IntAct=EBI-10975473, EBI-1104552;
CC O60333-2; Q15049: MLC1; NbExp=3; IntAct=EBI-10975473, EBI-8475277;
CC O60333-2; A0A0A0MR05: MLST8; NbExp=3; IntAct=EBI-10975473, EBI-25835557;
CC O60333-2; Q8N594: MPND; NbExp=3; IntAct=EBI-10975473, EBI-2512452;
CC O60333-2; Q9Y605: MRFAP1; NbExp=3; IntAct=EBI-10975473, EBI-995714;
CC O60333-2; Q96HT8: MRFAP1L1; NbExp=3; IntAct=EBI-10975473, EBI-748896;
CC O60333-2; Q8IXL7-2: MSRB3; NbExp=3; IntAct=EBI-10975473, EBI-10699187;
CC O60333-2; Q9NPC7: MYNN; NbExp=3; IntAct=EBI-10975473, EBI-3446748;
CC O60333-2; P28331-5: NDUFS1; NbExp=3; IntAct=EBI-10975473, EBI-25876328;
CC O60333-2; O76041: NEBL; NbExp=3; IntAct=EBI-10975473, EBI-2880203;
CC O60333-2; I6L9F6: NEFL; NbExp=3; IntAct=EBI-10975473, EBI-10178578;
CC O60333-2; Q8N5V2: NGEF; NbExp=3; IntAct=EBI-10975473, EBI-718372;
CC O60333-2; Q8NBF2-2: NHLRC2; NbExp=3; IntAct=EBI-10975473, EBI-10697320;
CC O60333-2; Q14995: NR1D2; NbExp=3; IntAct=EBI-10975473, EBI-6144053;
CC O60333-2; Q96MF7: NSMCE2; NbExp=3; IntAct=EBI-10975473, EBI-2557388;
CC O60333-2; Q6X4W1-6: NSMF; NbExp=3; IntAct=EBI-10975473, EBI-25842707;
CC O60333-2; P36639-4: NUDT1; NbExp=3; IntAct=EBI-10975473, EBI-25834643;
CC O60333-2; Q7Z417: NUFIP2; NbExp=3; IntAct=EBI-10975473, EBI-1210753;
CC O60333-2; O15381-5: NVL; NbExp=3; IntAct=EBI-10975473, EBI-18577082;
CC O60333-2; Q5BJF6-2: ODF2; NbExp=3; IntAct=EBI-10975473, EBI-9090919;
CC O60333-2; O43482: OIP5; NbExp=3; IntAct=EBI-10975473, EBI-536879;
CC O60333-2; Q96FW1: OTUB1; NbExp=3; IntAct=EBI-10975473, EBI-1058491;
CC O60333-2; Q6GQQ9-2: OTUD7B; NbExp=3; IntAct=EBI-10975473, EBI-25830200;
CC O60333-2; Q9NR21-5: PARP11; NbExp=3; IntAct=EBI-10975473, EBI-17159452;
CC O60333-2; Q9HBE1-4: PATZ1; NbExp=3; IntAct=EBI-10975473, EBI-11022007;
CC O60333-2; P22061-2: PCMT1; NbExp=3; IntAct=EBI-10975473, EBI-12386584;
CC O60333-2; Q9NV79: PCMTD2; NbExp=3; IntAct=EBI-10975473, EBI-6309018;
CC O60333-2; Q9BRX2: PELO; NbExp=3; IntAct=EBI-10975473, EBI-1043580;
CC O60333-2; O15534: PER1; NbExp=3; IntAct=EBI-10975473, EBI-2557276;
CC O60333-2; Q96FX8: PERP; NbExp=3; IntAct=EBI-10975473, EBI-17183069;
CC O60333-2; Q96LB9: PGLYRP3; NbExp=3; IntAct=EBI-10975473, EBI-12339509;
CC O60333-2; Q7RTV0: PHF5A; NbExp=3; IntAct=EBI-10975473, EBI-2555365;
CC O60333-2; O75925: PIAS1; NbExp=3; IntAct=EBI-10975473, EBI-629434;
CC O60333-2; Q9UF11-2: PLEKHB1; NbExp=3; IntAct=EBI-10975473, EBI-12832742;
CC O60333-2; Q58EX7-2: PLEKHG4; NbExp=3; IntAct=EBI-10975473, EBI-21503705;
CC O60333-2; Q6ZR37: PLEKHG7; NbExp=3; IntAct=EBI-10975473, EBI-12891828;
CC O60333-2; Q99541: PLIN2; NbExp=3; IntAct=EBI-10975473, EBI-2115275;
CC O60333-2; Q8TBJ4: PLPPR1; NbExp=3; IntAct=EBI-10975473, EBI-18063495;
CC O60333-2; Q8NA72-3: POC5; NbExp=3; IntAct=EBI-10975473, EBI-11751537;
CC O60333-2; Q9H1D9: POLR3F; NbExp=3; IntAct=EBI-10975473, EBI-710067;
CC O60333-2; O43741: PRKAB2; NbExp=3; IntAct=EBI-10975473, EBI-1053424;
CC O60333-2; P60891: PRPS1; NbExp=3; IntAct=EBI-10975473, EBI-749195;
CC O60333-2; P11908: PRPS2; NbExp=3; IntAct=EBI-10975473, EBI-4290895;
CC O60333-2; P28062-2: PSMB8; NbExp=3; IntAct=EBI-10975473, EBI-372312;
CC O60333-2; P47897: QARS1; NbExp=3; IntAct=EBI-10975473, EBI-347462;
CC O60333-2; Q9Y5P3: RAI2; NbExp=3; IntAct=EBI-10975473, EBI-746228;
CC O60333-2; Q96PK6: RBM14; NbExp=3; IntAct=EBI-10975473, EBI-954272;
CC O60333-2; Q9P2K3-2: RCOR3; NbExp=3; IntAct=EBI-10975473, EBI-1504830;
CC O60333-2; Q6NTF9-3: RHBDD2; NbExp=3; IntAct=EBI-10975473, EBI-17589229;
CC O60333-2; Q8TDP1: RNASEH2C; NbExp=3; IntAct=EBI-10975473, EBI-9027335;
CC O60333-2; Q8N5U6: RNF10; NbExp=3; IntAct=EBI-10975473, EBI-714023;
CC O60333-2; Q8WVD3: RNF138; NbExp=3; IntAct=EBI-10975473, EBI-749039;
CC O60333-2; Q96D59: RNF183; NbExp=3; IntAct=EBI-10975473, EBI-743938;
CC O60333-2; Q9H0X6: RNF208; NbExp=3; IntAct=EBI-10975473, EBI-751555;
CC O60333-2; P62244: RPS15A; NbExp=3; IntAct=EBI-10975473, EBI-347895;
CC O60333-2; P08865: RPSA; NbExp=3; IntAct=EBI-10975473, EBI-354112;
CC O60333-2; Q66K80: RUSC1-AS1; NbExp=3; IntAct=EBI-10975473, EBI-10248967;
CC O60333-2; Q8N488: RYBP; NbExp=3; IntAct=EBI-10975473, EBI-752324;
CC O60333-2; Q8N6K7-2: SAMD3; NbExp=3; IntAct=EBI-10975473, EBI-11528848;
CC O60333-2; Q7Z3H4: SAMD7; NbExp=3; IntAct=EBI-10975473, EBI-12148649;
CC O60333-2; P34741: SDC2; NbExp=3; IntAct=EBI-10975473, EBI-1172957;
CC O60333-2; O00560: SDCBP; NbExp=3; IntAct=EBI-10975473, EBI-727004;
CC O60333-2; Q9NTN9-3: SEMA4G; NbExp=3; IntAct=EBI-10975473, EBI-9089805;
CC O60333-2; Q96B97: SH3KBP1; NbExp=3; IntAct=EBI-10975473, EBI-346595;
CC O60333-2; Q9NUL5-3: SHFL; NbExp=3; IntAct=EBI-10975473, EBI-22000547;
CC O60333-2; Q8IYI0: SHLD1; NbExp=3; IntAct=EBI-10975473, EBI-2560428;
CC O60333-2; O60902-3: SHOX2; NbExp=3; IntAct=EBI-10975473, EBI-9092164;
CC O60333-2; P12757: SKIL; NbExp=3; IntAct=EBI-10975473, EBI-2902468;
CC O60333-2; P08195-4: SLC3A2; NbExp=3; IntAct=EBI-10975473, EBI-12832276;
CC O60333-2; Q9NSD5-3: SLC6A13; NbExp=3; IntAct=EBI-10975473, EBI-25831241;
CC O60333-2; Q92966: SNAPC3; NbExp=3; IntAct=EBI-10975473, EBI-1760638;
CC O60333-2; Q13573: SNW1; NbExp=3; IntAct=EBI-10975473, EBI-632715;
CC O60333-2; Q99932-2: SPAG8; NbExp=3; IntAct=EBI-10975473, EBI-11959123;
CC O60333-2; A0A024R4B0: SPATA3; NbExp=3; IntAct=EBI-10975473, EBI-14123856;
CC O60333-2; Q8TCT7-2: SPPL2B; NbExp=3; IntAct=EBI-10975473, EBI-8345366;
CC O60333-2; Q7Z698: SPRED2; NbExp=3; IntAct=EBI-10975473, EBI-7082156;
CC O60333-2; Q9C004: SPRY4; NbExp=3; IntAct=EBI-10975473, EBI-354861;
CC O60333-2; Q99619: SPSB2; NbExp=3; IntAct=EBI-10975473, EBI-2323209;
CC O60333-2; Q8IXS7: SRGAP3; NbExp=3; IntAct=EBI-10975473, EBI-18616594;
CC O60333-2; O75886: STAM2; NbExp=3; IntAct=EBI-10975473, EBI-373258;
CC O60333-2; Q8NBJ7: SUMF2; NbExp=3; IntAct=EBI-10975473, EBI-723091;
CC O60333-2; Q9H7C4: SYNC; NbExp=3; IntAct=EBI-10975473, EBI-11285923;
CC O60333-2; Q17RD7-3: SYT16; NbExp=3; IntAct=EBI-10975473, EBI-25861603;
CC O60333-2; Q86TJ2-3: TADA2B; NbExp=3; IntAct=EBI-10975473, EBI-18173581;
CC O60333-2; Q5VWN6: TASOR2; NbExp=3; IntAct=EBI-10975473, EBI-745958;
CC O60333-2; Q8IYN2: TCEAL8; NbExp=3; IntAct=EBI-10975473, EBI-2116184;
CC O60333-2; Q9BQ70: TCF25; NbExp=3; IntAct=EBI-10975473, EBI-745182;
CC O60333-2; Q13569: TDG; NbExp=3; IntAct=EBI-10975473, EBI-348333;
CC O60333-2; Q86WV5: TEN1; NbExp=3; IntAct=EBI-10975473, EBI-2562799;
CC O60333-2; Q96A09: TENT5B; NbExp=3; IntAct=EBI-10975473, EBI-752030;
CC O60333-2; Q8NA77: TEX19; NbExp=3; IntAct=EBI-10975473, EBI-13323487;
CC O60333-2; P21980-2: TGM2; NbExp=3; IntAct=EBI-10975473, EBI-25842075;
CC O60333-2; O60830: TIMM17B; NbExp=3; IntAct=EBI-10975473, EBI-2372529;
CC O60333-2; Q8N0U2: TMEM61; NbExp=3; IntAct=EBI-10975473, EBI-25830583;
CC O60333-2; Q8IUR5-4: TMTC1; NbExp=3; IntAct=EBI-10975473, EBI-9089156;
CC O60333-2; Q71RG4-4: TMUB2; NbExp=3; IntAct=EBI-10975473, EBI-25831574;
CC O60333-2; P36406: TRIM23; NbExp=3; IntAct=EBI-10975473, EBI-740098;
CC O60333-2; Q9UPQ4-2: TRIM35; NbExp=3; IntAct=EBI-10975473, EBI-17716262;
CC O60333-2; L8E9Q5: TRIM65; NbExp=3; IntAct=EBI-10975473, EBI-25843781;
CC O60333-2; Q86WT6-2: TRIM69; NbExp=3; IntAct=EBI-10975473, EBI-11525489;
CC O60333-2; Q9C026: TRIM9; NbExp=3; IntAct=EBI-10975473, EBI-720828;
CC O60333-2; Q86WV8: TSC1; NbExp=3; IntAct=EBI-10975473, EBI-12806590;
CC O60333-2; Q9Y3Q8: TSC22D4; NbExp=3; IntAct=EBI-10975473, EBI-739485;
CC O60333-2; Q9BUF5: TUBB6; NbExp=3; IntAct=EBI-10975473, EBI-356735;
CC O60333-2; Q9UGJ1-2: TUBGCP4; NbExp=3; IntAct=EBI-10975473, EBI-10964469;
CC O60333-2; Q5VYS8-5: TUT7; NbExp=3; IntAct=EBI-10975473, EBI-9088812;
CC O60333-2; Q9BSL1: UBAC1; NbExp=3; IntAct=EBI-10975473, EBI-749370;
CC O60333-2; Q8NBM4-4: UBAC2; NbExp=3; IntAct=EBI-10975473, EBI-25840976;
CC O60333-2; Q969T4: UBE2E3; NbExp=3; IntAct=EBI-10975473, EBI-348496;
CC O60333-2; Q13404: UBE2V1; NbExp=3; IntAct=EBI-10975473, EBI-1050671;
CC O60333-2; Q04323-2: UBXN1; NbExp=3; IntAct=EBI-10975473, EBI-11530712;
CC O60333-2; O75604-3: USP2; NbExp=3; IntAct=EBI-10975473, EBI-10696113;
CC O60333-2; P45880: VDAC2; NbExp=3; IntAct=EBI-10975473, EBI-354022;
CC O60333-2; P40337-2: VHL; NbExp=3; IntAct=EBI-10975473, EBI-12157263;
CC O60333-2; Q8NEZ2: VPS37A; NbExp=3; IntAct=EBI-10975473, EBI-2850578;
CC O60333-2; P58304: VSX2; NbExp=3; IntAct=EBI-10975473, EBI-6427899;
CC O60333-2; Q9BQA1: WDR77; NbExp=3; IntAct=EBI-10975473, EBI-1237307;
CC O60333-2; Q9BRX9: WDR83; NbExp=3; IntAct=EBI-10975473, EBI-7705033;
CC O60333-2; Q15007-2: WTAP; NbExp=3; IntAct=EBI-10975473, EBI-25840023;
CC O60333-2; Q9NZC7-5: WWOX; NbExp=3; IntAct=EBI-10975473, EBI-12040603;
CC O60333-2; O43167-2: ZBTB24; NbExp=3; IntAct=EBI-10975473, EBI-25842419;
CC O60333-2; Q53FD0-2: ZC2HC1C; NbExp=3; IntAct=EBI-10975473, EBI-14104088;
CC O60333-2; Q15776: ZKSCAN8; NbExp=3; IntAct=EBI-10975473, EBI-2602314;
CC O60333-2; Q9UJW8-4: ZNF180; NbExp=3; IntAct=EBI-10975473, EBI-12055755;
CC O60333-2; Q8N895: ZNF366; NbExp=3; IntAct=EBI-10975473, EBI-2813661;
CC O60333-2; Q9C0F3: ZNF436; NbExp=3; IntAct=EBI-10975473, EBI-8489702;
CC O60333-2; Q8N0Y2-2: ZNF444; NbExp=3; IntAct=EBI-10975473, EBI-12010736;
CC O60333-2; Q96MN9-2: ZNF488; NbExp=3; IntAct=EBI-10975473, EBI-25831733;
CC O60333-2; Q6ZNH5: ZNF497; NbExp=3; IntAct=EBI-10975473, EBI-10486136;
CC O60333-2; Q96C55: ZNF524; NbExp=3; IntAct=EBI-10975473, EBI-10283126;
CC O60333-2; Q68EA5: ZNF57; NbExp=3; IntAct=EBI-10975473, EBI-8490788;
CC O60333-2; Q7Z3I7: ZNF572; NbExp=3; IntAct=EBI-10975473, EBI-10172590;
CC O60333-2; Q96N77-2: ZNF641; NbExp=3; IntAct=EBI-10975473, EBI-12939666;
CC O60333-2; Q9BS34: ZNF670; NbExp=3; IntAct=EBI-10975473, EBI-745276;
CC O60333-2; Q3KNS6-3: ZNF829; NbExp=3; IntAct=EBI-10975473, EBI-18036029;
CC O60333-2; Q15695: ZRSR2P1; NbExp=3; IntAct=EBI-10975473, EBI-12270264;
CC O60333-2; O15535: ZSCAN9; NbExp=3; IntAct=EBI-10975473, EBI-751531;
CC O60333-2; Q2QGD7: ZXDC; NbExp=3; IntAct=EBI-10975473, EBI-1538838;
CC O60333-2; A0A384ME25; NbExp=3; IntAct=EBI-10975473, EBI-10211777;
CC O60333-2; B4DLR9; NbExp=3; IntAct=EBI-10975473, EBI-25851268;
CC O60333-2; B7Z3E8; NbExp=3; IntAct=EBI-10975473, EBI-25831617;
CC O60333-2; Q7L8T7; NbExp=3; IntAct=EBI-10975473, EBI-25831943;
CC O60333-2; Q7Z783; NbExp=3; IntAct=EBI-10975473, EBI-9088990;
CC O60333-2; Q86V28; NbExp=3; IntAct=EBI-10975473, EBI-10259496;
CC O60333-3; Q12959: DLG1; NbExp=4; IntAct=EBI-465669, EBI-357481;
CC O60333-3; P78352: DLG4; NbExp=4; IntAct=EBI-465669, EBI-80389;
CC O60333-3; Q96QZ7: MAGI1; NbExp=3; IntAct=EBI-465669, EBI-924464;
CC O60333-3; Q63622: Dlg2; Xeno; NbExp=3; IntAct=EBI-465669, EBI-396947;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Mitochondrion
CC {ECO:0000269|PubMed:16225668}. Cell projection, axon
CC {ECO:0000250|UniProtKB:Q60575}.
CC -!- SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasmic vesicle, secretory
CC vesicle, synaptic vesicle {ECO:0000250|UniProtKB:O88658}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=O60333-1; Sequence=Displayed;
CC Name=2; Synonyms=Beta;
CC IsoId=O60333-2; Sequence=VSP_002858, VSP_002859;
CC Name=3; Synonyms=Alpha;
CC IsoId=O60333-3; Sequence=VSP_002858, VSP_002859, VSP_002860,
CC VSP_002861;
CC Name=4;
CC IsoId=O60333-4; Sequence=VSP_009381;
CC -!- TISSUE SPECIFICITY: Isoform 3 is abundant in the skeletal muscle. It is
CC also expressed in fetal brain, lung and kidney, and adult heart,
CC placenta, testis, ovary and small intestine. Isoform 2 is abundant in
CC the brain and also expressed in fetal heart, lung, liver and kidney,
CC and adult skeletal muscle, placenta, liver, kidney, heart, spleen,
CC thymus, prostate, testis, ovary, small intestine, colon and pancreas.
CC {ECO:0000269|PubMed:10762626, ECO:0000269|PubMed:11526494,
CC ECO:0000269|PubMed:12888911}.
CC -!- DISEASE: Charcot-Marie-Tooth disease 2A1 (CMT2A1) [MIM:118210]: A
CC dominant axonal form of Charcot-Marie-Tooth disease, a disorder of the
CC peripheral nervous system, characterized by progressive weakness and
CC atrophy, initially of the peroneal muscles and later of the distal
CC muscles of the arms. Charcot-Marie-Tooth disease is classified in two
CC main groups on the basis of electrophysiologic properties and
CC histopathology: primary peripheral demyelinating neuropathies
CC (designated CMT1 when they are dominantly inherited) and primary
CC peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group
CC are characterized by signs of axonal degeneration in the absence of
CC obvious myelin alterations, normal or slightly reduced nerve conduction
CC velocities, and progressive distal muscle weakness and atrophy.
CC {ECO:0000269|PubMed:11389829}. Note=The disease may be caused by
CC variants affecting the gene represented in this entry.
CC -!- DISEASE: Neuroblastoma 1 (NBLST1) [MIM:256700]: A common neoplasm of
CC early childhood arising from embryonic cells that form the primitive
CC neural crest and give rise to the adrenal medulla and the sympathetic
CC nervous system. Note=Disease susceptibility is associated with variants
CC affecting the gene represented in this entry.
CC -!- DISEASE: Pheochromocytoma (PCC) [MIM:171300]: A catecholamine-producing
CC tumor of chromaffin tissue of the adrenal medulla or sympathetic
CC paraganglia. The cardinal symptom, reflecting the increased secretion
CC of epinephrine and norepinephrine, is hypertension, which may be
CC persistent or intermittent. {ECO:0000269|PubMed:18334619}. Note=Disease
CC susceptibility is associated with variants affecting the gene
CC represented in this entry.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. Unc-104 subfamily. {ECO:0000255|PROSITE-
CC ProRule:PRU00283}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH01415.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAP35838.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAA25517.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAA95972.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAB69038.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Inherited peripheral neuropathies mutation db;
CC URL="https://uantwerpen.vib.be/CMTMutations";
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DR EMBL; AX039604; CAC16629.1; -; Genomic_DNA.
DR EMBL; AB017133; BAB69038.1; ALT_INIT; mRNA.
DR EMBL; AF257176; AAK49332.1; -; mRNA.
DR EMBL; AY043362; AAK85155.1; -; mRNA.
DR EMBL; AB088210; BAE02543.1; -; mRNA.
DR EMBL; AY139835; AAN17742.1; -; mRNA.
DR EMBL; AB011163; BAA25517.2; ALT_INIT; mRNA.
DR EMBL; AB040881; BAA95972.2; ALT_INIT; mRNA.
DR EMBL; AL139424; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL358013; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC001415; AAH01415.1; ALT_INIT; mRNA.
DR EMBL; BC115395; AAI15396.1; -; mRNA.
DR EMBL; BT007174; AAP35838.1; ALT_INIT; mRNA.
DR EMBL; AK022977; BAB14341.1; -; mRNA.
DR CCDS; CCDS111.1; -. [O60333-2]
DR CCDS; CCDS112.1; -. [O60333-3]
DR RefSeq; NP_055889.2; NM_015074.3. [O60333-2]
DR RefSeq; NP_904325.2; NM_183416.3. [O60333-3]
DR PDB; 2EH0; NMR; -; A=531-647.
DR PDBsum; 2EH0; -.
DR AlphaFoldDB; O60333; -.
DR SMR; O60333; -.
DR BioGRID; 116723; 141.
DR DIP; DIP-33015N; -.
DR IntAct; O60333; 336.
DR MINT; O60333; -.
DR STRING; 9606.ENSP00000263934; -.
DR BindingDB; O60333; -.
DR ChEMBL; CHEMBL5889; -.
DR GlyGen; O60333; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; O60333; -.
DR MetOSite; O60333; -.
DR PhosphoSitePlus; O60333; -.
DR SwissPalm; O60333; -.
DR BioMuta; KIF1B; -.
DR EPD; O60333; -.
DR jPOST; O60333; -.
DR MassIVE; O60333; -.
DR MaxQB; O60333; -.
DR PaxDb; O60333; -.
DR PeptideAtlas; O60333; -.
DR PRIDE; O60333; -.
DR ProteomicsDB; 49353; -. [O60333-1]
DR ProteomicsDB; 49354; -. [O60333-2]
DR ProteomicsDB; 49355; -. [O60333-3]
DR ProteomicsDB; 49356; -. [O60333-4]
DR Antibodypedia; 4196; 118 antibodies from 24 providers.
DR DNASU; 23095; -.
DR Ensembl; ENST00000263934.10; ENSP00000263934.6; ENSG00000054523.19. [O60333-2]
DR Ensembl; ENST00000377081.5; ENSP00000366284.1; ENSG00000054523.19. [O60333-4]
DR Ensembl; ENST00000377083.5; ENSP00000366287.1; ENSG00000054523.19. [O60333-3]
DR Ensembl; ENST00000377086.5; ENSP00000366290.1; ENSG00000054523.19. [O60333-1]
DR Ensembl; ENST00000377093.9; ENSP00000366297.4; ENSG00000054523.19. [O60333-3]
DR Ensembl; ENST00000676179.1; ENSP00000502065.1; ENSG00000054523.19. [O60333-1]
DR GeneID; 23095; -.
DR KEGG; hsa:23095; -.
DR MANE-Select; ENST00000676179.1; ENSP00000502065.1; NM_001365951.3; NP_001352880.1.
DR UCSC; uc001aqv.5; human. [O60333-1]
DR CTD; 23095; -.
DR DisGeNET; 23095; -.
DR GeneCards; KIF1B; -.
DR GeneReviews; KIF1B; -.
DR HGNC; HGNC:16636; KIF1B.
DR HPA; ENSG00000054523; Group enriched (brain, retina, skeletal muscle, tongue).
DR MalaCards; KIF1B; -.
DR MIM; 118210; phenotype.
DR MIM; 171300; phenotype.
DR MIM; 256700; phenotype.
DR MIM; 605995; gene.
DR neXtProt; NX_O60333; -.
DR OpenTargets; ENSG00000054523; -.
DR Orphanet; 99946; Autosomal dominant Charcot-Marie-Tooth disease type 2A1.
DR Orphanet; 29072; Hereditary pheochromocytoma-paraganglioma.
DR PharmGKB; PA38176; -.
DR VEuPathDB; HostDB:ENSG00000054523; -.
DR eggNOG; KOG0245; Eukaryota.
DR GeneTree; ENSGT00940000157445; -.
DR HOGENOM; CLU_009645_0_0_1; -.
DR InParanoid; O60333; -.
DR OMA; GSMDQKT; -.
DR OrthoDB; 76316at2759; -.
DR PhylomeDB; O60333; -.
DR TreeFam; TF105221; -.
DR PathwayCommons; O60333; -.
DR Reactome; R-HSA-6811434; COPI-dependent Golgi-to-ER retrograde traffic.
DR Reactome; R-HSA-983189; Kinesins.
DR SignaLink; O60333; -.
DR BioGRID-ORCS; 23095; 8 hits in 1075 CRISPR screens.
DR ChiTaRS; KIF1B; human.
DR EvolutionaryTrace; O60333; -.
DR GeneWiki; KIF1B; -.
DR GenomeRNAi; 23095; -.
DR Pharos; O60333; Tbio.
DR PRO; PR:O60333; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; O60333; protein.
DR Bgee; ENSG00000054523; Expressed in skeletal muscle tissue of rectus abdominis and 199 other tissues.
DR ExpressionAtlas; O60333; baseline and differential.
DR Genevisible; O60333; HS.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0030424; C:axon; IBA:GO_Central.
DR GO; GO:1904115; C:axon cytoplasm; IEA:GOC.
DR GO; GO:0031410; C:cytoplasmic vesicle; ISS:UniProtKB.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; ISS:UniProtKB.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0005871; C:kinesin complex; IBA:GO_Central.
DR GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR GO; GO:0005875; C:microtubule associated complex; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0043005; C:neuron projection; ISS:UniProtKB.
DR GO; GO:0008021; C:synaptic vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR GO; GO:0019894; F:kinesin binding; TAS:UniProtKB.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0003777; F:microtubule motor activity; IBA:GO_Central.
DR GO; GO:0008574; F:plus-end-directed microtubule motor activity; ISS:UniProtKB.
DR GO; GO:0008089; P:anterograde axonal transport; ISS:UniProtKB.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0030705; P:cytoskeleton-dependent intracellular transport; ISS:UniProtKB.
DR GO; GO:0007018; P:microtubule-based movement; ISS:UniProtKB.
DR GO; GO:0007274; P:neuromuscular synaptic transmission; ISS:UniProtKB.
DR GO; GO:0007270; P:neuron-neuron synaptic transmission; ISS:UniProtKB.
DR GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR CDD; cd00060; FHA; 1.
DR Gene3D; 2.30.29.30; -; 1.
DR Gene3D; 3.40.850.10; -; 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR022164; Kinesin-like.
DR InterPro; IPR027640; Kinesin-like_fam.
DR InterPro; IPR022140; Kinesin-like_KIF1-typ.
DR InterPro; IPR032405; Kinesin_assoc.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR24115; PTHR24115; 1.
DR Pfam; PF12473; DUF3694; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF12423; KIF1B; 1.
DR Pfam; PF00225; Kinesin; 1.
DR Pfam; PF16183; Kinesin_assoc; 1.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00240; FHA; 1.
DR SMART; SM00129; KISc; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF49879; SSF49879; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Alternative splicing; Apoptosis; ATP-binding;
KW Cell projection; Charcot-Marie-Tooth disease; Coiled coil; Cytoplasm;
KW Cytoplasmic vesicle; Cytoskeleton; Disease variant; Microtubule;
KW Mitochondrion; Motor protein; Neurodegeneration; Neuropathy;
KW Nucleotide-binding; Phosphoprotein; Reference proteome; Synapse.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0007744|PubMed:22814378"
FT CHAIN 2..1816
FT /note="Kinesin-like protein KIF1B"
FT /id="PRO_0000125407"
FT DOMAIN 5..354
FT /note="Kinesin motor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00283"
FT DOMAIN 556..612
FT /note="FHA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00086"
FT DOMAIN 1702..1799
FT /note="PH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT REGION 270..350
FT /note="Interaction with KBP"
FT /evidence="ECO:0000269|PubMed:16225668"
FT REGION 431..450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1550..1570
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1617..1660
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 365..386
FT /evidence="ECO:0000255"
FT COILED 470..502
FT /evidence="ECO:0000255"
FT COILED 668..737
FT /evidence="ECO:0000255"
FT COILED 841..869
FT /evidence="ECO:0000255"
FT COMPBIAS 1550..1568
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 97..104
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00283"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0007744|PubMed:22814378"
FT MOD_RES 647
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q60575"
FT MOD_RES 652
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q60575"
FT MOD_RES 1054
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 1057
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163"
FT MOD_RES 1075
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:19690332"
FT MOD_RES 1416
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 1454
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:20068231,
FT ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569"
FT MOD_RES 1487
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19690332,
FT ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163"
FT MOD_RES 1573
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 1603
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 1610
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:20068231"
FT MOD_RES 1613
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:20068231,
FT ECO:0007744|PubMed:24275569"
FT VAR_SEQ 289..294
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:10819331,
FT ECO:0000303|PubMed:12888911, ECO:0000303|PubMed:15489334,
FT ECO:0000303|Ref.4"
FT /id="VSP_002858"
FT VAR_SEQ 394..434
FT /note="IDPLIDDYSGSGSKYLKDFQNNKHRYLLASENQRPGHFSTA -> T (in
FT isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:10819331,
FT ECO:0000303|PubMed:12888911, ECO:0000303|PubMed:15489334,
FT ECO:0000303|Ref.4"
FT /id="VSP_002859"
FT VAR_SEQ 707..1196
FT /note="YESKLQALQKQVETRSLAAETTEEEEEEEEVPWTQHEFELAQWAFRKWKSHQ
FT FTSLRDLLWGNAVYLKEANAISVELKKKVQFQFVLLTDTLYSPLPPELLPTEMEKTHED
FT RPFPRTVVAVEVQDLKNGATHYWSLEKLKQRLDLMREMYDRAGEMASSAQDESETTVTG
FT SDPFYDRFHWFKLVGSSPIFHGCVNERLADRTPSPTFSTADSDITELADEQQDEMEDFD
FT DEAFVDDAGSDAGTEEGSDLFSDGHDPFYDRSPWFILVGRAFVYLSNLLYPVPLIHRVA
FT IVSEKGEVRGFLRVAVQAIAADEEAPDYGSGIRQSGTAKISFDNEYFNQSDFSSVAMTR
FT SGLSLEELRIVEGQGQSSEVITPPEEISRINDLDLKSSTLLDGKMVMEGFSEEIGNHLK
FT LGSAFTFRVTVLQASGILPEYADIFCQFNFLHRHDEAFSTEPLKNNGRGSPLAFYHVQN
FT IAVEITESFVDYIKTKPIVFEVFGH -> ADSDSGDDSDKRSCEESWKLITSLREKLPP
FT SKLQTIVKKCGLPSSGKKREPIKMYQIPQRRRLSKDSKWVTISDLKIQAVKEICYEVAL
FT NDFRHSRQEIEALAIVKMKELCAMYGKKDPNERDSWRAVARDVWDTVGVGDEKIEDVMA
FT TGKGSTDVDDLKVHIDKLEDILQEVKKQNNMKDEEIKVLRNKMLKMEKVLPLIGSQEQK
FT SPGSHKAKEPVGAGVSSTSENNVSKGDNGELAKEERVSQLMNGDPAFRRGRLRWMRQEQ
FT IRFKNLQQQEITKQLRRQNVPHRFIPPENRKPRFPFKSNPKHRNSWSPGTHIIITEDEV
FT IELRIPKDDEARKGNKEESQEKGGKGAFKDPQFPWGSQGMRSQDHIQVSKQHINNQQQP
FT PQLRWRSNSLNNGQPKSTRCQASASAESLNSHSGHPTADVQTFQAKRHIHQHRQSYCNY
FT NTGGQLEGNAATSYQKQTDKPSHCSQFVTPPRMRRQFSAPNLKAGRETTV (in
FT isoform 3)"
FT /evidence="ECO:0000303|PubMed:10819331,
FT ECO:0000303|PubMed:12888911, ECO:0000303|PubMed:15489334,
FT ECO:0000303|Ref.4"
FT /id="VSP_002860"
FT VAR_SEQ 1197..1816
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:10819331,
FT ECO:0000303|PubMed:12888911, ECO:0000303|PubMed:15489334,
FT ECO:0000303|Ref.4"
FT /id="VSP_002861"
FT VAR_SEQ 1804..1816
FT /note="SKLSRRCPSQSKY -> PGHLASEIIREDKSVSFSCQ (in isoform
FT 4)"
FT /evidence="ECO:0000303|PubMed:10762626, ECO:0000303|Ref.5"
FT /id="VSP_009381"
FT VARIANT 34
FT /note="S -> L (in a medulloblastoma sample; somatic
FT mutation; loss of ability to induce apoptosis;
FT dbSNP:rs1269940164)"
FT /evidence="ECO:0000269|PubMed:18334619"
FT /id="VAR_063531"
FT VARIANT 98
FT /note="Q -> L (in CMT2A1; dbSNP:rs121908160)"
FT /evidence="ECO:0000269|PubMed:11389829"
FT /id="VAR_011515"
FT VARIANT 692
FT /note="E -> V (confers susceptibility to neuroblastoma;
FT found as germline mutation in a neuroblastoma patient; loss
FT of ability to induce apoptosis; dbSNP:rs121908161)"
FT /evidence="ECO:0000269|PubMed:18334619"
FT /id="VAR_063532"
FT VARIANT 873
FT /note="T -> I (confers susceptibility to neuroblastoma;
FT found as germline mutation in a neuroblastoma patient; loss
FT of ability to induce apoptosis; dbSNP:rs121908162)"
FT /evidence="ECO:0000269|PubMed:18334619"
FT /id="VAR_063533"
FT VARIANT 1133
FT /note="Y -> C (in dbSNP:rs2297881)"
FT /evidence="ECO:0000269|PubMed:18334619"
FT /id="VAR_063534"
FT VARIANT 1263
FT /note="P -> S (confers susceptibility to neuroblastoma;
FT found as germline mutation in a neuroblastoma patient; loss
FT of ability to induce apoptosis; dbSNP:rs121908163)"
FT /evidence="ECO:0000269|PubMed:18334619"
FT /id="VAR_063535"
FT VARIANT 1527
FT /note="S -> N (confers susceptibility to pheochromocytoma;
FT found as germline mutation in a pheochromocytoma family;
FT loss of ability to induce apoptosis; dbSNP:rs121908164)"
FT /evidence="ECO:0000269|PubMed:18334619"
FT /id="VAR_063536"
FT VARIANT 1600
FT /note="V -> M (in dbSNP:rs77172218)"
FT /evidence="ECO:0000269|PubMed:18334619"
FT /id="VAR_063537"
FT VARIANT 1674
FT /note="E -> K (in a pheochromocytoma sample; loss of
FT ability to induce apoptosis; dbSNP:rs143669846)"
FT /evidence="ECO:0000269|PubMed:18334619"
FT /id="VAR_063538"
FT CONFLICT 87
FT /note="E -> G (in Ref. 8; BAA25517)"
FT /evidence="ECO:0000305"
FT CONFLICT 129..131
FT /note="KIN -> TNH (in Ref. 3; AAK49332, 4; AAK85155 and 5;
FT AAN17742)"
FT /evidence="ECO:0000305"
FT CONFLICT 170
FT /note="E -> D (in Ref. 3; AAK49332, 4; AAK85155 and 5;
FT AAN17742)"
FT /evidence="ECO:0000305"
FT CONFLICT 174
FT /note="L -> R (in Ref. 3; AAK49332, 4; AAK85155 and 5;
FT AAN17742)"
FT /evidence="ECO:0000305"
FT CONFLICT 219..221
FT /note="AVF -> VVY (in Ref. 3; AAK49332, 4; AAK85155 and 5;
FT AAN17742)"
FT /evidence="ECO:0000305"
FT CONFLICT 235..239
FT /note="NLSTE -> ILATV (in Ref. 3; AAK49332, 4; AAK85155 and
FT 5; AAN17742)"
FT /evidence="ECO:0000305"
FT CONFLICT 244
FT /note="I -> T (in Ref. 3; AAK49332, 4; AAK85155 and 5;
FT AAN17742)"
FT /evidence="ECO:0000305"
FT CONFLICT 253
FT /note="E -> D (in Ref. 3; AAK49332, 4; AAK85155 and 5;
FT AAN17742)"
FT /evidence="ECO:0000305"
FT CONFLICT 256
FT /note="D -> A (in Ref. 3; AAK49332, 4; AAK85155 and 5;
FT AAN17742)"
FT /evidence="ECO:0000305"
FT CONFLICT 270
FT /note="N -> I (in Ref. 3; AAK49332, 4; AAK85155 and 5;
FT AAN17742)"
FT /evidence="ECO:0000305"
FT CONFLICT 363
FT /note="D -> G (in Ref. 2; BAB69038)"
FT /evidence="ECO:0000305"
FT STRAND 533..535
FT /evidence="ECO:0007829|PDB:2EH0"
FT STRAND 547..550
FT /evidence="ECO:0007829|PDB:2EH0"
FT STRAND 553..559
FT /evidence="ECO:0007829|PDB:2EH0"
FT STRAND 563..565
FT /evidence="ECO:0007829|PDB:2EH0"
FT STRAND 568..570
FT /evidence="ECO:0007829|PDB:2EH0"
FT STRAND 573..575
FT /evidence="ECO:0007829|PDB:2EH0"
FT STRAND 580..587
FT /evidence="ECO:0007829|PDB:2EH0"
FT STRAND 593..597
FT /evidence="ECO:0007829|PDB:2EH0"
FT STRAND 601..603
FT /evidence="ECO:0007829|PDB:2EH0"
FT STRAND 605..607
FT /evidence="ECO:0007829|PDB:2EH0"
FT STRAND 625..629
FT /evidence="ECO:0007829|PDB:2EH0"
FT STRAND 633..635
FT /evidence="ECO:0007829|PDB:2EH0"
FT HELIX 637..640
FT /evidence="ECO:0007829|PDB:2EH0"
FT TURN 641..645
FT /evidence="ECO:0007829|PDB:2EH0"
FT MOD_RES O60333-3:663
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21406692"
FT MOD_RES O60333-3:665
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21406692,
FT ECO:0007744|PubMed:24275569"
FT MOD_RES O60333-3:1141
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:20068231"
SQ SEQUENCE 1816 AA; 204476 MW; AD62F0515978C783 CRC64;
MSGASVKVAV RVRPFNSRET SKESKCIIQM QGNSTSIINP KNPKEAPKSF SFDYSYWSHT
SPEDPCFASQ NRVYNDIGKE MLLHAFEGYN VCIFAYGQTG AGKSYTMMGK QEESQAGIIP
QLCEELFEKI NDNCNEEMSY SVEVSYMEIY CERVRDLLNP KNKGNLRVRE HPLLGPYVED
LSKLAVTSYT DIADLMDAGN KARTVAATNM NETSSRSHAV FTIVFTQKKH DNETNLSTEK
VSKISLVDLA GSERADSTGA KGTRLKEGAN INKSLTTLGK VISALAEVDN CTSKSKKKKK
TDFIPYRDSV LTWLLRENLG GNSRTAMVAA LSPADINYDE TLSTLRYADR AKQIKCNAVI
NEDPNAKLVR ELKEEVTRLK DLLRAQGLGD IIDIDPLIDD YSGSGSKYLK DFQNNKHRYL
LASENQRPGH FSTASMGSLT SSPSSCSLSS QVGLTSVTSI QERIMSTPGG EEAIERLKES
EKIIAELNET WEEKLRKTEA IRMEREALLA EMGVAIREDG GTLGVFSPKK TPHLVNLNED
PLMSECLLYY IKDGITRVGQ ADAERRQDIV LSGAHIKEEH CIFRSERSNS GEVIVTLEPC
ERSETYVNGK RVSQPVQLRS GNRIIMGKNH VFRFNHPEQA RAEREKTPSA ETPSEPVDWT
FAQRELLEKQ GIDMKQEMEK RLQEMEILYK KEKEEADLLL EQQRLDYESK LQALQKQVET
RSLAAETTEE EEEEEEVPWT QHEFELAQWA FRKWKSHQFT SLRDLLWGNA VYLKEANAIS
VELKKKVQFQ FVLLTDTLYS PLPPELLPTE MEKTHEDRPF PRTVVAVEVQ DLKNGATHYW
SLEKLKQRLD LMREMYDRAG EMASSAQDES ETTVTGSDPF YDRFHWFKLV GSSPIFHGCV
NERLADRTPS PTFSTADSDI TELADEQQDE MEDFDDEAFV DDAGSDAGTE EGSDLFSDGH
DPFYDRSPWF ILVGRAFVYL SNLLYPVPLI HRVAIVSEKG EVRGFLRVAV QAIAADEEAP
DYGSGIRQSG TAKISFDNEY FNQSDFSSVA MTRSGLSLEE LRIVEGQGQS SEVITPPEEI
SRINDLDLKS STLLDGKMVM EGFSEEIGNH LKLGSAFTFR VTVLQASGIL PEYADIFCQF
NFLHRHDEAF STEPLKNNGR GSPLAFYHVQ NIAVEITESF VDYIKTKPIV FEVFGHYQQH
PLHLQGQELN SPPQPCRRFF PPPMPLSKPV PATKLNTMSK TSLGQSMSKY DLLVWFEISE
LEPTGEYIPA VVDHTAGLPC QGTFLLHQGI QRRITVTIIH EKGSELHWKD VRELVVGRIR
NKPEVDEAAV DAILSLNIIS AKYLKSSHNS SRTFYRFEAV WDSSLHNSLL LNRVTPYGEK
IYMTLSAYLE LDHCIQPAVI TKDVCMVFYS RDAKISPPRS LRSLFGSGYS KSPDSNRVTG
IYELSLCKMS DTGSPGMQRR RRKILDTSVA YVRGEENLAG WRPRGDSLIL EHQWELEKLE
LLHEVEKTRH FLLLRERLGD SIPKSLSDSL SPSLSSGTLS TSTSISSQIS TTTFESAITP
SESSGYDSGD IESLVDREKE LATKCLQLLT HTFNREFSQV HGSVSDCKLS DISPIGRDPS
ESSFSSATLT PSSTCPSLVD SRSNSLDQKT PEANSRASSP CPEFEQFQIV PAVETPYLAR
AGKNEFLNLV PDIEEIRPSS VVSKKGYLHF KEPLYSNWAK HFVVVRRPYV FIYNSDKDPV
ERGIINLSTA QVEYSEDQQA MVKTPNTFAV CTKHRGVLLQ ALNDKDMNDW LYAFNPLLAG
TIRSKLSRRC PSQSKY
