ID   KIF22_XENTR             Reviewed;         639 AA.
AC   Q6P3R1;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Kinesin-like protein KIF22;
DE   AltName: Full=Chromokinesin kid;
GN   Name=kif22; Synonyms=kid;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Kinesin family member that is involved in spindle formation
CC       and the movements of chromosomes during mitosis and meiosis. Binds to
CC       microtubules and to DNA. {ECO:0000250|UniProtKB:Q9I869}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9I869}.
CC       Cytoplasm, cytoskeleton {ECO:0000305}.
CC   -!- PTM: Ubiquitinated, leading to its subsequent proteasomal degradation.
CC       {ECO:0000250|UniProtKB:Q9I869}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC       superfamily. Kinesin family. {ECO:0000255|PROSITE-ProRule:PRU00283}.
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DR   EMBL; BC063896; AAH63896.1; -; mRNA.
DR   RefSeq; NP_989245.1; NM_203914.1.
DR   AlphaFoldDB; Q6P3R1; -.
DR   SMR; Q6P3R1; -.
DR   PaxDb; Q6P3R1; -.
DR   DNASU; 394855; -.
DR   GeneID; 394855; -.
DR   KEGG; xtr:394855; -.
DR   CTD; 3835; -.
DR   Xenbase; XB-GENE-979888; kif22.
DR   eggNOG; KOG0242; Eukaryota.
DR   InParanoid; Q6P3R1; -.
DR   OrthoDB; 787964at2759; -.
DR   Proteomes; UP000008143; Chromosome 9.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005871; C:kinesin complex; IBA:GO_Central.
DR   GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR   GO; GO:0003777; F:microtubule motor activity; IBA:GO_Central.
DR   GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central.
DR   Gene3D; 3.40.850.10; -; 1.
DR   InterPro; IPR026986; KIF22.
DR   InterPro; IPR027640; Kinesin-like_fam.
DR   InterPro; IPR019821; Kinesin_motor_CS.
DR   InterPro; IPR001752; Kinesin_motor_dom.
DR   InterPro; IPR036961; Kinesin_motor_dom_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010994; RuvA_2-like.
DR   PANTHER; PTHR24115; PTHR24115; 1.
DR   PANTHER; PTHR24115:SF801; PTHR24115:SF801; 1.
DR   Pfam; PF00225; Kinesin; 1.
DR   PRINTS; PR00380; KINESINHEAVY.
DR   SMART; SM00129; KISc; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR   PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Coiled coil; Cytoplasm; Cytoskeleton; DNA-binding;
KW   Microtubule; Motor protein; Nucleotide-binding; Nucleus;
KW   Reference proteome; Ubl conjugation.
FT   CHAIN           1..639
FT                   /note="Kinesin-like protein KIF22"
FT                   /id="PRO_0000347240"
FT   DOMAIN          18..345
FT                   /note="Kinesin motor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00283"
FT   REGION          358..400
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          439..484
FT                   /evidence="ECO:0000255"
FT   MOTIF           549..552
FT                   /note="Important for regulated proteolytic degradation"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        365..387
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         102..109
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00283"
SQ   SEQUENCE   639 AA;  71391 MW;  F5664F9020A6A1AA CRC64;
     MAKRVSILDQ HKKPSSARVR VAVRLRPYME KEDEKAPAAC VRGLDSQSLE IVNWRNQLET
     MQYQFDAFYG DSATQREIYM GSVCHILPHL LIGQNASVFA YGPTGAGKTH TMLGNPSQPG
     VIPRAVRDLL QMTRTAAGGP ENENWTYTIT MSYVEIYQEK VMDLLEPKNK DLPIREDKDH
     NILIPGVTQK TINSFGDFDE HFIPASQNRT VASTKLNDRS SRSHAVLLIK VQKSQQVSPF
     RQLTGKLYLI DLAGSEDNRR TGNQGIRLKE SGAINSSLFT LSKVVDALNQ GLPRIPYRDS
     KLTRLLQDSL GGTAHSVMIA NIAPEQKYYF DTLTALNFAA KSKQIINKPF SQETTQSIAA
     LPAMKRPREE AETAAGSRQR KKSKTDSTES SPNTSMDAAS KRKLNLAALD PAVVERLLKL
     DKILTEKGMK EAQLLSTPKR ERMALLKKWE ESQMEIERLK EKQKELEQKA IEAEARLEKS
     TNSDCNLSDS SVSECTFRAP LRGRNTSTAK AKKVLRVLPM QGNSQLQSTI EEGIPVFEKK
     KKKPVSCDGR ENQPTWEVNV RTDLLESGRE RILKLLNTGS VKELKSLQKI GDKKAKLIIG
     WREVNGPFKN VEDLASLEGI SAKQVTSFIK ANILSIIAS