ID   KIF28_HUMAN             Reviewed;         967 AA.
AC   B7ZC32;
DT   22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT   22-FEB-2012, sequence version 2.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Kinesin-like protein KIF28P;
DE   AltName: Full=Kinesin-like protein 6;
GN   Name=KIF28P; Synonyms=KLP6;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
CC   -!- FUNCTION: Microtubule-dependent motor protein required for
CC       mitochondrion morphology and transport of mitochondria in neuronal
CC       cells. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC       superfamily. Kinesin family. {ECO:0000255|PROSITE-ProRule:PRU00283}.
CC   -!- CAUTION: The sequence of the protein was deduced from the genomic
CC       sequence and ESTs by similarity to the mouse and rat sequence.
CC       {ECO:0000305}.
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DR   EMBL; AC113174; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL591848; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; B7ZC32; -.
DR   SMR; B7ZC32; -.
DR   IntAct; B7ZC32; 1.
DR   GlyConnect; 2836; 1 N-Linked glycan (1 site).
DR   GlyGen; B7ZC32; 1 site, 1 N-linked glycan (1 site).
DR   iPTMnet; B7ZC32; -.
DR   PhosphoSitePlus; B7ZC32; -.
DR   SwissPalm; B7ZC32; -.
DR   BioMuta; HGNC:49205; -.
DR   jPOST; B7ZC32; -.
DR   MassIVE; B7ZC32; -.
DR   PeptideAtlas; B7ZC32; -.
DR   PRIDE; B7ZC32; -.
DR   ProteomicsDB; 7170; -.
DR   GeneCards; KIF28P; -.
DR   HGNC; HGNC:49205; KIF28P.
DR   neXtProt; NX_B7ZC32; -.
DR   InParanoid; B7ZC32; -.
DR   PathwayCommons; B7ZC32; -.
DR   Reactome; R-HSA-6811434; COPI-dependent Golgi-to-ER retrograde traffic.
DR   Reactome; R-HSA-983189; Kinesins.
DR   SignaLink; B7ZC32; -.
DR   ChiTaRS; KIF28P; human.
DR   Pharos; B7ZC32; Tdark.
DR   PRO; PR:B7ZC32; -.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; B7ZC32; protein.
DR   GO; GO:0005871; C:kinesin complex; IBA:GO_Central.
DR   GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR   GO; GO:0031966; C:mitochondrial membrane; ISS:UniProtKB.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR   GO; GO:0003777; F:microtubule motor activity; IBA:GO_Central.
DR   GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central.
DR   GO; GO:0007005; P:mitochondrion organization; ISS:UniProtKB.
DR   GO; GO:0072384; P:organelle transport along microtubule; ISS:UniProtKB.
DR   CDD; cd00060; FHA; 1.
DR   Gene3D; 3.40.850.10; -; 1.
DR   InterPro; IPR000253; FHA_dom.
DR   InterPro; IPR027640; Kinesin-like_fam.
DR   InterPro; IPR022140; Kinesin-like_KIF1-typ.
DR   InterPro; IPR001752; Kinesin_motor_dom.
DR   InterPro; IPR036961; Kinesin_motor_dom_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR008984; SMAD_FHA_dom_sf.
DR   PANTHER; PTHR24115; PTHR24115; 2.
DR   Pfam; PF12423; KIF1B; 1.
DR   Pfam; PF00225; Kinesin; 1.
DR   PRINTS; PR00380; KINESINHEAVY.
DR   SMART; SM00129; KISc; 1.
DR   SUPFAM; SSF49879; SSF49879; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Coiled coil; Membrane; Mitochondrion; Motor protein;
KW   Nucleotide-binding; Reference proteome; Transport.
FT   CHAIN           1..967
FT                   /note="Kinesin-like protein KIF28P"
FT                   /id="PRO_0000415569"
FT   DOMAIN          7..355
FT                   /note="Kinesin motor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00283"
FT   DOMAIN          410..472
FT                   /note="FHA"
FT   COILED          822..851
FT                   /evidence="ECO:0000255"
FT   BINDING         111..118
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00283"
SQ   SEQUENCE   967 AA;  108254 MW;  D87C3E911441DDE6 CRC64;
     MPTQSVDSVK AVRVRPFSQR EKNSGSKCVI SMHSRTTTTT QDPKNPEHVK TFTFDLAYWS
     HNGFQRDKDG VLISADPSRK FAGQRDVFHD LGRGILDSAW QGYNATLLAY GQTGSGKSYS
     MIGFGCKQGI IPTVCEELFR AIENQGRNQE HQVMFSMLEI YKEIIRDLLS RTKKPGGLRI
     REDQQLGFYV EGLKSVPCEN YAQIERLMEQ GTKIRTTAST NMNASSSRSH LVITIQFKQV
     FLDRDLTKQS SINLVDLARS ERQKSSGSEG DRLREGSCVN LSLTNLGSVI SVLADAAMGK
     KVLHIPYRDS VLTKLLQSAL GGNSRTALVA AVSPADICYE ETLSTLRYAE RERKIRNRAV
     ANTWTLMRKS RAENSKLLPM MTFPHLLNLS EDPQLTRVLK YFIQAGTQPA PCPRPALSPP
     HPALRISDKH ASFTNADGKV TVTPHSKCKV AVNGVPITTR TKLQHLDRLI LGSNSTYLYV
     GFPSEWGSED LSRFDYDFFQ LERAAAEGAS ADKLGAADGG DGKAGPSVLA AFQDYIKLMP
     LVSEANQMSE EPKKGLNMEL KVKNLASSDS RGYDLQKEVL VKVTHHGSHE VWIWSKAKFI
     NRKFLMQELY QRFLDGDHGP VARDDDPFWD PVEVVRLGSA HIWLQSLAYC MKLEEQVEFL
     NCDGLEEAVL HTCIAPCSPT GQTHGEEDVV IDPLELLGKR MDFQIHIVRC LGVNWMKEDA
     KRGTQIGYRI YDLPNTIYTK PVWKSVNPQI EETVQFAALT ASQEFLNYLR TNALIVDLWG
     LQEGCTELSC SQLGLMVTGE GHILVDTKKI STVKDISQAA SNQIPELYLK LLKLEQETEP
     LRNINRALRE ENVLLKASLA KTASGQAPKP SNTLKISGMT AQLPSAGEMS QMCTQQAGSD
     RELAKALKVF YQSMNTARGQ LFRLRRHQPP EVDQMLRPFI HQRSQMFKDL GDLRESSLWT
     LKMTLLL