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KIF28_MOUSE
ID   KIF28_MOUSE             Reviewed;        1028 AA.
AC   D3YXS5;
DT   22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT   20-APR-2010, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Kinesin-like protein KIF28 {ECO:0000305};
DE   AltName: Full=Kinesin family member 28 {ECO:0000312|MGI:MGI:2686151};
DE   AltName: Full=Kinesin-like protein 6;
GN   Name=Kif28p {ECO:0000312|MGI:MGI:2686151};
GN   Synonyms=Gm1305 {ECO:0000312|MGI:MGI:2686151},
GN   Kif28 {ECO:0000312|MGI:MGI:2686151}, Klp6;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
CC   -!- FUNCTION: Microtubule-dependent motor protein required for
CC       mitochondrion morphology and transport of mitochondria in neuronal
CC       cells. {ECO:0000250|UniProtKB:F8WLE0}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane
CC       {ECO:0000250|UniProtKB:F8WLE0}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:F8WLE0}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC       superfamily. Kinesin family. {ECO:0000255|PROSITE-ProRule:PRU00283}.
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DR   EMBL; AC113977; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; D3YXS5; -.
DR   SMR; D3YXS5; -.
DR   STRING; 10090.ENSMUSP00000118935; -.
DR   EPD; D3YXS5; -.
DR   PaxDb; D3YXS5; -.
DR   PeptideAtlas; D3YXS5; -.
DR   PRIDE; D3YXS5; -.
DR   MGI; MGI:2686151; Kif28.
DR   eggNOG; KOG0245; Eukaryota.
DR   InParanoid; D3YXS5; -.
DR   TreeFam; TF105223; -.
DR   Reactome; R-MMU-2132295; MHC class II antigen presentation.
DR   Reactome; R-MMU-6811434; COPI-dependent Golgi-to-ER retrograde traffic.
DR   Reactome; R-MMU-983189; Kinesins.
DR   PRO; PR:D3YXS5; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; D3YXS5; protein.
DR   GO; GO:0005871; C:kinesin complex; IBA:GO_Central.
DR   GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR   GO; GO:0031966; C:mitochondrial membrane; ISS:UniProtKB.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR   GO; GO:0003777; F:microtubule motor activity; IBA:GO_Central.
DR   GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central.
DR   GO; GO:0007005; P:mitochondrion organization; ISS:UniProtKB.
DR   GO; GO:0072384; P:organelle transport along microtubule; ISS:UniProtKB.
DR   CDD; cd00060; FHA; 1.
DR   Gene3D; 3.40.850.10; -; 1.
DR   InterPro; IPR000253; FHA_dom.
DR   InterPro; IPR027640; Kinesin-like_fam.
DR   InterPro; IPR022140; Kinesin-like_KIF1-typ.
DR   InterPro; IPR019821; Kinesin_motor_CS.
DR   InterPro; IPR001752; Kinesin_motor_dom.
DR   InterPro; IPR036961; Kinesin_motor_dom_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR008984; SMAD_FHA_dom_sf.
DR   PANTHER; PTHR24115; PTHR24115; 1.
DR   Pfam; PF00498; FHA; 1.
DR   Pfam; PF12423; KIF1B; 1.
DR   Pfam; PF00225; Kinesin; 1.
DR   PRINTS; PR00380; KINESINHEAVY.
DR   SMART; SM00240; FHA; 1.
DR   SMART; SM00129; KISc; 1.
DR   SUPFAM; SSF49879; SSF49879; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR   PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Coiled coil; Membrane; Mitochondrion; Motor protein;
KW   Nucleotide-binding; Reference proteome; Transport.
FT   CHAIN           1..1028
FT                   /note="Kinesin-like protein KIF28"
FT                   /id="PRO_0000415570"
FT   DOMAIN          11..358
FT                   /note="Kinesin motor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00283"
FT   DOMAIN          460..523
FT                   /note="FHA"
FT   COILED          873..902
FT                   /evidence="ECO:0000255"
FT   BINDING         114..121
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00283"
SQ   SEQUENCE   1028 AA;  114827 MW;  565C7D9F81AB5BD1 CRC64;
     MGRVPVPRSD SVRVAVRVRP FSQREKNSGS QCVISMHSGN ISIRDPKNEE RVKTFTFDLT
     YWSHDGFQKD EDGVLIPSDP ASKFAGQSDV FHDIGRGILD SAWRGYNATL LAYGQTGSGK
     SYSMIGFGTN KGLIPRVCEE LFQAIEKQKE NLEPQVMFSM LEIYNEQIRD LLSRTKAPGG
     LRVREDQQLG FFVEGLKWVP CENYAQIEKL VEQGSKIRMT ASTNMNASSS RSHMLIAIQF
     KQVFLDTALT KRSSINMVDL AGSERQRSSG SEGDRLREGS RVNLSLTSLG NVISALADLA
     MGKKVLHIPY RDSVLTKLLQ SALGGNSRTT LIAALSPADI CYEETLSTLR YAERAKKVRN
     RAVINTCPLA RASRAENALL LGFRGAGAAE HPACFWAEQQ LGNQGTWAQL LEQARREWEE
     QYEALTQEQK MVRILPHLLN VNEDPQLTGV LKFFIHNGSC DVGRAASNAI CLQGLGISDK
     HASFVNLDGK VTVAPHSKCK VIVNGVPVTG RTKLQHLDRI ILGSNSAFLY VGFPSERGAE
     DLSRFDYDFF QLERAAAEGV SVATLGCVSP GDDQADPSIL AVFQDYVKLM PLVVEANQMS
     EELKKGLTME LKVKNLASSD SRGYDLQKEV MVKVTKQGTH EVWIWSKAKF INRKFLMEEL
     YQRFLESRDS HVAQEDDPFW DPLEVVHLGS AHVWLQPLAH CMMLEEQVEF LNCDGLEEAV
     LHIRITPCSP EGWAHGEEDM VIDPLELLGK RIDFQTHIVR CLGVKWLKED GSRGIQMGYG
     IYDLPNTLYT KPVWKSVNPR IEETVHFAAL GASREFLDYL LTNALIVDLW GLQEGCAPLG
     VSQLDVLLTG EGHIMVDTKT FSSVKDVSQI TSNQVPELYQ KLLKLEQETE LLRDVNRALR
     GENVFLKASL ENAGSAPQAQ KLDNPEGATR TAAREAKQVC AQQASSDAQL ARALKVFYQG
     MGVARGQLLR LRRCRPPEDD QMLRPFVHQQ SQMLKDLEDL LESSLHKLKA DVAFIVKKRK
     EYLLPSQQ
 
 
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