ID   KIF28_RAT               Reviewed;        1034 AA.
AC   F8WLE0;
DT   22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT   19-OCT-2011, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Kinesin-like protein KIF28P;
DE   AltName: Full=Kinesin-like protein 6;
GN   Name=Kif28p; Synonyms=Klp6;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=21693574; DOI=10.1242/jcs.086470;
RA   Tanaka K., Sugiura Y., Ichishita R., Mihara K., Oka T.;
RT   "KLP6: a newly identified kinesin that regulates the morphology and
RT   transport of mitochondria in neuronal cells.";
RL   J. Cell Sci. 124:2457-2465(2011).
CC   -!- FUNCTION: Microtubule-dependent motor protein required for
CC       mitochondrion morphology and transport of mitochondria in neuronal
CC       cells. {ECO:0000269|PubMed:21693574}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane
CC       {ECO:0000269|PubMed:21693574}; Peripheral membrane protein
CC       {ECO:0000269|PubMed:21693574}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC       superfamily. Kinesin family. {ECO:0000255|PROSITE-ProRule:PRU00283}.
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DR   EMBL; AB573712; BAK54843.1; -; mRNA.
DR   RefSeq; NP_001257314.1; NM_001270385.1.
DR   AlphaFoldDB; F8WLE0; -.
DR   SMR; F8WLE0; -.
DR   STRING; 10116.ENSRNOP00000064972; -.
DR   PaxDb; F8WLE0; -.
DR   PRIDE; F8WLE0; -.
DR   Ensembl; ENSRNOT00000075426; ENSRNOP00000064972; ENSRNOG00000050602.
DR   GeneID; 289309; -.
DR   KEGG; rno:289309; -.
DR   CTD; 100130097; -.
DR   RGD; 1559696; Kif28p.
DR   eggNOG; KOG0245; Eukaryota.
DR   GeneTree; ENSGT00940000163104; -.
DR   HOGENOM; CLU_001485_2_3_1; -.
DR   InParanoid; F8WLE0; -.
DR   OMA; HYKPPED; -.
DR   OrthoDB; 76316at2759; -.
DR   Reactome; R-RNO-2132295; MHC class II antigen presentation.
DR   Reactome; R-RNO-6811434; COPI-dependent Golgi-to-ER retrograde traffic.
DR   Reactome; R-RNO-983189; Kinesins.
DR   PRO; PR:F8WLE0; -.
DR   Proteomes; UP000002494; Chromosome 13.
DR   Genevisible; F8WLE0; RN.
DR   GO; GO:0005871; C:kinesin complex; IBA:GO_Central.
DR   GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR   GO; GO:0031966; C:mitochondrial membrane; IDA:UniProtKB.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR   GO; GO:0003777; F:microtubule motor activity; IBA:GO_Central.
DR   GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central.
DR   GO; GO:0007005; P:mitochondrion organization; IDA:UniProtKB.
DR   GO; GO:0072384; P:organelle transport along microtubule; IMP:UniProtKB.
DR   CDD; cd00060; FHA; 1.
DR   Gene3D; 3.40.850.10; -; 1.
DR   InterPro; IPR000253; FHA_dom.
DR   InterPro; IPR027640; Kinesin-like_fam.
DR   InterPro; IPR022140; Kinesin-like_KIF1-typ.
DR   InterPro; IPR019821; Kinesin_motor_CS.
DR   InterPro; IPR001752; Kinesin_motor_dom.
DR   InterPro; IPR036961; Kinesin_motor_dom_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR008984; SMAD_FHA_dom_sf.
DR   PANTHER; PTHR24115; PTHR24115; 1.
DR   Pfam; PF00498; FHA; 1.
DR   Pfam; PF12423; KIF1B; 1.
DR   Pfam; PF00225; Kinesin; 1.
DR   PRINTS; PR00380; KINESINHEAVY.
DR   SMART; SM00129; KISc; 1.
DR   SUPFAM; SSF49879; SSF49879; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR   PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Coiled coil; Membrane; Mitochondrion; Motor protein;
KW   Nucleotide-binding; Reference proteome; Transport.
FT   CHAIN           1..1034
FT                   /note="Kinesin-like protein KIF28P"
FT                   /id="PRO_0000415571"
FT   DOMAIN          16..363
FT                   /note="Kinesin motor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00283"
FT   DOMAIN          465..528
FT                   /note="FHA"
FT   COILED          875..904
FT                   /evidence="ECO:0000255"
FT   COILED          994..1027
FT                   /evidence="ECO:0000255"
FT   BINDING         119..126
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00283"
SQ   SEQUENCE   1034 AA;  115542 MW;  1BD858FE0CE65813 CRC64;
     MDCEKMGKLP VPRTDSVRVA VRVRPFSQRE KNSGSQCVIS MHARSITIRD PKDAELVKTF
     TFDLAYWSHD GFQKDEDGVL IPSDPTSKFA GQSDVFHDIG RGILDSAWQG YNATLLAYGQ
     TGSGKSYSMI GYGANKGIIP RVCEELFQAI EKQKESLEAQ VMFSMLEIYN EQIRDLLSRT
     KAPGGLRVRE DQRLGFFVEG LKWVPCEDSV QIEKLVEQGS KIRMTASTNM NASSSRSHML
     IAIRFKQVFL DTALTKQSSI NMVDLAGSER QRSSGSEGDR LREGSRVNLS LTNLGNVISA
     LADLAMGKKV LHIPYRDSVL TKLLQSALGG NSRTTLIAAL SPADICYEET LSTLRYAERA
     KKVRNRAVIN TCPLVRASRA ENALLLGFGG AGAAEHSACF WAEQQLGTWG TWAQLLEQAR
     REWEQQYMAL AQEQQMVKIL PHLLNVNEDP QLTGVLKFFI HNGSCEVGRA ASNAICLQSL
     GISDKHASFT NMDGKVTVAP HITGKVIVNG VPVSSRTKLQ HLDRIILGSN SAFLYIGFPS
     ERGAEDLGRF DYDFFQMERA AAEGVSVDML GTASPGDDQA DPSILAVFQD YIKLMPLVVE
     ANQMSEELKK GLKMELKVKN LASSDSRGCD LQKEVMVKVT KQGTHEVWIW SKAKFINRKF
     LMEELYQRFL ESRDSHVAQE DDPFWDPVEV LHLGSAHVWL QSLAHRMMLE EQVEFLNCEG
     LEEAVLHIQI TPCSPEGWAH GEEDTVIDPL ELLGKRIDFQ IHIVQCLGVK WLKEDATRGI
     QLGYKVYDLP NTLYTKPVWQ SVNPRVEESV HFAALGVSRE FLNYLLTNAL VVDLWGLQEG
     CAHLGVSQPD VLFTGEGYIM VDTKTFSSVK DITSNQVPEL YQKLLKLEQE TELLRDINRA
     LRGENVYLKA ALENAGSAPQ GERRYHKPDN PEGATVTAAG EAKQMCAQRA SSDSQLARAL
     KVFYGGMSVA RGQLLRLRQC RPPEDDQMLR PFVHQQSQML KDLEDLLESS LQKLKSDVAF
     IVKKKKEYLL PRGR