KIF2A_CHICK
ID KIF2A_CHICK Reviewed; 706 AA.
AC Q5ZKV8;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 02-OCT-2007, sequence version 2.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Kinesin-like protein KIF2A;
GN Name=KIF2A {ECO:0000250|UniProtKB:O00139}; ORFNames=RCJMB04_9a7;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1] {ECO:0000312|EMBL:CAG31635.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB {ECO:0000312|EMBL:CAG31635.1};
RC TISSUE=Bursa of Fabricius {ECO:0000312|EMBL:CAG31635.1};
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Plus end-directed microtubule-dependent motor required for
CC normal brain development. May regulate microtubule dynamics during
CC axonal growth. Required for normal progression through mitosis.
CC Required for normal congress of chromosomes at the metaphase plate.
CC Required for normal spindle dynamics during mitosis. Promotes spindle
CC turnover. Implicated in formation of bipolar mitotic spindles. Has
CC microtubule depolymerization activity (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P28740}.
CC Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
CC {ECO:0000250|UniProtKB:P28740}. Cytoplasm, cytoskeleton, spindle pole
CC {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}.
CC Note=Localized to the spindle microtubules and spindle poles from
CC prophase to metaphase. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. MCAK/KIF2 subfamily. {ECO:0000255|PROSITE-
CC ProRule:PRU00283}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAG31635.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AJ719976; CAG31635.1; ALT_INIT; mRNA.
DR RefSeq; NP_001034401.2; NM_001039312.2.
DR AlphaFoldDB; Q5ZKV8; -.
DR SMR; Q5ZKV8; -.
DR STRING; 9031.ENSGALP00000023720; -.
DR PaxDb; Q5ZKV8; -.
DR GeneID; 427156; -.
DR KEGG; gga:427156; -.
DR CTD; 3796; -.
DR VEuPathDB; HostDB:geneid_427156; -.
DR eggNOG; KOG0246; Eukaryota.
DR InParanoid; Q5ZKV8; -.
DR PhylomeDB; Q5ZKV8; -.
DR PRO; PR:Q5ZKV8; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005871; C:kinesin complex; IBA:GO_Central.
DR GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR GO; GO:0005819; C:spindle; IBA:GO_Central.
DR GO; GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0003777; F:microtubule motor activity; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central.
DR GO; GO:0007052; P:mitotic spindle organization; ISS:UniProtKB.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR Gene3D; 3.40.850.10; -; 1.
DR InterPro; IPR027640; Kinesin-like_fam.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24115; PTHR24115; 1.
DR Pfam; PF00225; Kinesin; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Cell cycle; Cell division; Coiled coil; Cytoplasm;
KW Cytoskeleton; Developmental protein; Differentiation; Microtubule; Mitosis;
KW Motor protein; Neurogenesis; Nucleotide-binding; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..706
FT /note="Kinesin-like protein KIF2A"
FT /id="PRO_0000306274"
FT DOMAIN 223..553
FT /note="Kinesin motor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00283"
FT REGION 64..187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 154..187
FT /evidence="ECO:0000255"
FT COILED 662..699
FT /evidence="ECO:0000255"
FT COMPBIAS 115..140
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 149..187
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 313..320
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 706 AA; 79864 MW; 6C5CA4DAE3DA1EC8 CRC64;
MAAANFGKIQ IGIYVEIKRS DGRIHQAMVT SLNEDNESVT VEWIENGDTK GKEIDLESIF
SLNPDLAPDE DIEPSPETQP LPAPSAKVNK IVKGRRTVAP VKNDTPARDN RVASSARARP
TQLPEQSSSS QQNGTVSGIS PVQAAKKEFG PPSRRKSNCV KEVEKLQEKR EKRRLQQQEL
REKRAQDVDA TNPNYEIMCM IRDFRGNLDY RPLTTADPID EHRICVCVRK RPLNRKETLM
KDLDVITIPS KDVVMVHEPK QKVDLTRYLE NQTFRFDYAF DETAPNEMVY RFTARPLVET
IFERGMATCF AYGQTGSGKT HTMGGDFSGK NQDCSKGIYA LAARDVFLML KKPNYKKLEL
QVYATFFEIY SGKVFDLLNR KTKLRVLEDG KQQVQVVGLQ EREVKCVEDV LKLIEIGNSC
RTSGQTSANA HSSRSHAVFQ IILRRKGKLH GKFSLIDLAG NERGADTSSA DRQTRLEGAE
INKSLLALKE CIRALGRNKP HTPFRASKLT QVLRDSFIGE NSRTCMIATI SPGMASCENT
LNTLRYANRV KELTIDPSAA GDIRPIIHHT PSQIDDLDTQ WGVGSSPQRD DLKLLCEQNE
EEVSPQLFTF HEAVSQMVEM EEQVVEDHRT VFQESIRWLE DEKALLEMTE EVDYDVDSYA
TQLEAILDQK IDILTELRDK VKSFRAALQE EEQASKQINP KRPRAV
