KIF6_DICDI
ID KIF6_DICDI Reviewed; 1030 AA.
AC Q6S004; Q55F66; Q94499;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Kinesin-related protein 6;
DE AltName: Full=Kinesin family member 6;
DE AltName: Full=Kinesin-13;
GN Name=kif6; Synonyms=K6, ksnF; ORFNames=DDB_G0267404;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], IDENTIFICATION, AND NOMENCLATURE.
RC STRAIN=AX4;
RX PubMed=14641909; DOI=10.1186/1471-2164-4-47;
RA Kollmar M., Gloeckner G.;
RT "Identification and phylogenetic analysis of Dictyostelium discoideum
RT kinesin proteins.";
RL BMC Genomics 4:47-47(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 440-758, AND INDUCTION.
RC STRAIN=AX3;
RX PubMed=9693369; DOI=10.1091/mbc.9.8.2093;
RA de Hostos E.L., McCaffrey G., Sucgang R., Pierce D.W., Vale R.D.;
RT "A developmentally regulated kinesin-related motor protein from
RT Dictyostelium discoideum.";
RL Mol. Biol. Cell 9:2093-2106(1998).
CC -!- FUNCTION: Microtubule-associated force-producing protein that plays a
CC role in organelle transport. Its motor activity is directed toward the
CC microtubule's plus end (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}.
CC -!- INDUCTION: During the developmental stage.
CC {ECO:0000269|PubMed:9693369}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000255|PROSITE-ProRule:PRU00283}.
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DR EMBL; AY484461; AAR39437.1; -; Genomic_DNA.
DR EMBL; AAFI02000003; EAL73154.1; -; Genomic_DNA.
DR EMBL; U69984; AAB09082.1; -; mRNA.
DR RefSeq; XP_647667.1; XM_642575.1.
DR AlphaFoldDB; Q6S004; -.
DR SMR; Q6S004; -.
DR STRING; 44689.DDB0191499; -.
DR PaxDb; Q6S004; -.
DR PRIDE; Q6S004; -.
DR EnsemblProtists; EAL73154; EAL73154; DDB_G0267404.
DR GeneID; 8616484; -.
DR KEGG; ddi:DDB_G0267404; -.
DR dictyBase; DDB_G0267404; kif6.
DR eggNOG; KOG0246; Eukaryota.
DR HOGENOM; CLU_001485_19_2_1; -.
DR InParanoid; Q6S004; -.
DR OMA; CRENELQ; -.
DR PRO; PR:Q6S004; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0005813; C:centrosome; TAS:dictyBase.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IBA:GO_Central.
DR GO; GO:0007019; P:microtubule depolymerization; IBA:GO_Central.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR GO; GO:0007052; P:mitotic spindle organization; IMP:dictyBase.
DR Gene3D; 1.10.150.50; -; 1.
DR Gene3D; 3.40.850.10; -; 1.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR Pfam; PF00225; Kinesin; 1.
DR Pfam; PF00536; SAM_1; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF47769; SSF47769; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Cytoplasm; Cytoskeleton; Microtubule; Motor protein;
KW Nucleotide-binding; Reference proteome; Transport.
FT CHAIN 1..1030
FT /note="Kinesin-related protein 6"
FT /id="PRO_0000365581"
FT DOMAIN 3..66
FT /note="SAM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00184"
FT DOMAIN 453..775
FT /note="Kinesin motor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00283"
FT REGION 66..164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 178..308
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 826..915
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 981..1030
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 180..237
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 238..285
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 826..902
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 543..550
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 1030 AA; 118658 MW; D2A9B57AE3BF16A8 CRC64;
MDFENDQLYN WLQLANLESF YPNFIKKNVS CDSFLSFTMQ DYGNVGITSL QDRKKLFHLL
QQLKKQTPPI SNTSSPVINS NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNSSG
LRQPTSTSSL LSNNNLMSTQ TQQSSSSSSS SSLSSKSNSN SDFMQKAQQL LKQRELERQQ
YAKQQQQQQS TQTKYQSSLK DFDITSSNKN NNLDDFFEDD NLYSQQQQQQ QQQQQQQDFE
FEEEEEEEDQ QQQYDEEEEE EEEYEEDFYK EDLGEIDDGN VLDISDDEPD PNSSCIIVEG
SPDEEDDDVE YIPQNESLVN GFGSMKIQQQ QQQQFQPLQQ QQQQQQQQQQ QFYQQQIQQQ
QQQQQQQQQQ QVQQQQQQFN NFNYSGLNEE QIKYYQQQAQ YQQQVQQAQQ AAIQQAQQAA
ALAQASQQQL QQQEQQRQQA SNFFLDMNEY GQRIRVCVRK RPLNKKEIAK SEKDIIEVLP
KKDLIVNEPK TKLDLSKFIE KHKFTFDGVF DESANNYQVY LHTAYPLVDS IFHKGKATCF
AYGQTGSGKT HTQMGQQGDG LYALAARDIF HRLETYFKDQ LQVCISFFEI YGGKLFDLLN
ERKKLACREN ELQNVVIVGL SEKHVTSPQE LMNCIIDGNK IRSTGSTGVN SDSSRSHAIL
QISLKNIKTN KLHGKFSFID LAGSERGSDT YDNDKQTRKE GADINKSLLA LKECIRALDQ
SSKHTPFRQS TLTQVLKDSF VGNSRTVMIA NISPNQSSSE HTLNTLRYAD RVKELGTSES
NSNKKPVATY NIPAPLPPPD HLKQNFNDPI LIPSTTTTTT TTATAINSQQ PIIQQTSQPV
SKIKQPVKQQ QESQIPQTPQ QQQQQQPPQQ QPQQQQYNIP QTPQQTQQQF NIPQTPKQQQ
PIQTQPPMSP PKIDFVNYHR NHVDQFADIL KKELISINQF ESSKGSIPLE NYINNIEQFL
DSKQLLINHL RGIIQQHQQQ PIQQQQQQQQ PIQQQQQSTP QPSQLQTPQQ RERARSQLQP
PKPSIYSSRN
