KIF6_HUMAN
ID KIF6_HUMAN Reviewed; 814 AA.
AC Q6ZMV9; Q2MDE3; Q2MDE4; Q5T8J6; Q6ZWE3; Q86T87; Q8WTV4;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2007, sequence version 3.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Kinesin-like protein KIF6;
GN Name=KIF6; Synonyms=C6orf102;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4), AND VARIANT
RP ARG-719.
RC TISSUE=Amygdala, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 110-814 (ISOFORM 3).
RC TISSUE=Spinal cord;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [5]
RP VARIANT [LARGE SCALE ANALYSIS] GLU-386.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- INTERACTION:
CC Q6ZMV9; Q92624: APPBP2; NbExp=3; IntAct=EBI-751100, EBI-743771;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q6ZMV9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6ZMV9-2; Sequence=VSP_014468;
CC Name=3;
CC IsoId=Q6ZMV9-3; Sequence=VSP_014471;
CC Name=4;
CC IsoId=Q6ZMV9-4; Sequence=VSP_014468, VSP_014469, VSP_014470;
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000255|PROSITE-ProRule:PRU00283}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK123217; BAC85560.1; -; mRNA.
DR EMBL; AK131471; BAD18616.1; -; mRNA.
DR EMBL; AL035464; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL136087; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL160161; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL161439; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL590387; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC022074; AAH22074.1; -; mRNA.
DR EMBL; BX649045; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AL832634; CAD89950.1; -; mRNA.
DR CCDS; CCDS4844.1; -. [Q6ZMV9-1]
DR CCDS; CCDS75449.1; -. [Q6ZMV9-2]
DR RefSeq; NP_001275953.1; NM_001289024.1. [Q6ZMV9-2]
DR RefSeq; NP_659464.3; NM_145027.4. [Q6ZMV9-1]
DR RefSeq; XP_011512661.1; XM_011514359.2. [Q6ZMV9-3]
DR AlphaFoldDB; Q6ZMV9; -.
DR SMR; Q6ZMV9; -.
DR BioGRID; 128728; 7.
DR IntAct; Q6ZMV9; 8.
DR MINT; Q6ZMV9; -.
DR STRING; 9606.ENSP00000287152; -.
DR ChEMBL; CHEMBL3308907; -.
DR iPTMnet; Q6ZMV9; -.
DR PhosphoSitePlus; Q6ZMV9; -.
DR BioMuta; KIF6; -.
DR DMDM; 146345445; -.
DR jPOST; Q6ZMV9; -.
DR MassIVE; Q6ZMV9; -.
DR MaxQB; Q6ZMV9; -.
DR PaxDb; Q6ZMV9; -.
DR PeptideAtlas; Q6ZMV9; -.
DR PRIDE; Q6ZMV9; -.
DR ProteomicsDB; 67924; -. [Q6ZMV9-1]
DR ProteomicsDB; 67925; -. [Q6ZMV9-2]
DR ProteomicsDB; 67926; -. [Q6ZMV9-3]
DR ProteomicsDB; 67927; -. [Q6ZMV9-4]
DR Antibodypedia; 29939; 218 antibodies from 26 providers.
DR DNASU; 221458; -.
DR Ensembl; ENST00000229913.9; ENSP00000229913.5; ENSG00000164627.18. [Q6ZMV9-2]
DR Ensembl; ENST00000287152.12; ENSP00000287152.7; ENSG00000164627.18. [Q6ZMV9-1]
DR GeneID; 221458; -.
DR KEGG; hsa:221458; -.
DR MANE-Select; ENST00000287152.12; ENSP00000287152.7; NM_145027.6; NP_659464.3.
DR UCSC; uc003oos.3; human. [Q6ZMV9-1]
DR CTD; 221458; -.
DR DisGeNET; 221458; -.
DR GeneCards; KIF6; -.
DR HGNC; HGNC:21202; KIF6.
DR HPA; ENSG00000164627; Tissue enhanced (brain, testis).
DR MIM; 613919; gene.
DR neXtProt; NX_Q6ZMV9; -.
DR OpenTargets; ENSG00000164627; -.
DR PharmGKB; PA134920075; -.
DR VEuPathDB; HostDB:ENSG00000164627; -.
DR eggNOG; KOG0242; Eukaryota.
DR eggNOG; KOG4280; Eukaryota.
DR GeneTree; ENSGT00940000157697; -.
DR HOGENOM; CLU_001485_16_1_1; -.
DR InParanoid; Q6ZMV9; -.
DR OMA; KEIQHIQ; -.
DR OrthoDB; 424630at2759; -.
DR PhylomeDB; Q6ZMV9; -.
DR TreeFam; TF329752; -.
DR PathwayCommons; Q6ZMV9; -.
DR Reactome; R-HSA-6811434; COPI-dependent Golgi-to-ER retrograde traffic.
DR Reactome; R-HSA-983189; Kinesins.
DR SignaLink; Q6ZMV9; -.
DR BioGRID-ORCS; 221458; 14 hits in 1073 CRISPR screens.
DR ChiTaRS; KIF6; human.
DR GenomeRNAi; 221458; -.
DR Pharos; Q6ZMV9; Tbio.
DR PRO; PR:Q6ZMV9; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q6ZMV9; protein.
DR Bgee; ENSG00000164627; Expressed in right uterine tube and 137 other tissues.
DR ExpressionAtlas; Q6ZMV9; baseline and differential.
DR Genevisible; Q6ZMV9; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005871; C:kinesin complex; IBA:GO_Central.
DR GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0003777; F:microtubule motor activity; IBA:GO_Central.
DR GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central.
DR Gene3D; 3.40.850.10; -; 1.
DR InterPro; IPR027640; Kinesin-like_fam.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24115; PTHR24115; 1.
DR Pfam; PF00225; Kinesin; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; ATP-binding; Coiled coil; Cytoplasm; Cytoskeleton;
KW Microtubule; Motor protein; Nucleotide-binding; Reference proteome.
FT CHAIN 1..814
FT /note="Kinesin-like protein KIF6"
FT /id="PRO_0000125441"
FT DOMAIN 5..345
FT /note="Kinesin motor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00283"
FT REGION 752..788
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 356..385
FT /evidence="ECO:0000255"
FT COILED 456..494
FT /evidence="ECO:0000255"
FT COILED 588..683
FT /evidence="ECO:0000255"
FT COMPBIAS 757..775
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 97..104
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00283"
FT VAR_SEQ 1..549
FT /note="Missing (in isoform 2 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_014468"
FT VAR_SEQ 708..720
FT /note="PFLQTSDSQHEWS -> SKIKALADSMSVM (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_014469"
FT VAR_SEQ 721..814
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_014470"
FT VAR_SEQ 728..744
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_014471"
FT VARIANT 386
FT /note="A -> E (in a breast cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_036217"
FT VARIANT 512
FT /note="R -> H (in dbSNP:rs2273063)"
FT /id="VAR_049698"
FT VARIANT 719
FT /note="W -> R (in dbSNP:rs20455)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_022810"
FT CONFLICT 551
FT /note="R -> K (in Ref. 1; BAD18616)"
FT /evidence="ECO:0000305"
FT CONFLICT 558..584
FT /note="CQEAFEIFKRDHADSVTIDDNKQILKQ -> NATILSSLTGPGLQHFGEKIQ
FT FAPQEN (in Ref. 4; CAD89950)"
FT /evidence="ECO:0000305"
FT CONFLICT 715
FT /note="S -> F (in Ref. 1; BAD18616)"
FT /evidence="ECO:0000305"
FT CONFLICT 772
FT /note="E -> G (in Ref. 1; BAD18616)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 814 AA; 92569 MW; D0BB982845286F31 CRC64;
MVKQTIQIFA RVKPPVRKHQ QGIYSIDEDE KLIPSLEIIL PRDLADGFVN NKRESYKFKF
QRIFDQDANQ ETVFENIAKP VAGSVLAGYN GTIFAYGQTG SGKTFTITGG AERYSDRGII
PRTLSYIFEQ LQKDSSKIYT THISYLEIYN ECGYDLLDPR HEASSLEDLP KVTILEDPDQ
NIHLKNLTLH QATTEEEALN LLFLGDTNRM IAETPMNQAS TRSHCIFTIH LSSKEPGSAT
VRHAKLHLVD LAGSERVAKT GVGGHLLTEA KYINLSLHYL EQVIIALSEK HRSHIPYRNS
MMTSVLRDSL GGNCMTTMIA TLSLEKRNLD ESISTCRFAQ RVALIKNEAV LNEEINPRLV
IKRLQKEIQE LKDELAMVTG EQRTEALTEA ELLQLEKLIT SFLEDQDSDS RLEVGADMRK
VHHCFHHLKK LLNDKKILEN NTVSSESKDQ DCQEPLKEEE YRKLRDILKQ RDNEINILVN
MLKKEKKKAQ EALHLAGMDR REFRQSQSPP FRLGNPEEGQ RMRLSSAPSQ AQDFSILGKR
SSLLHKKIGM REEMSLGCQE AFEIFKRDHA DSVTIDDNKQ ILKQRFSEAK ALGESINEAR
SKIGHLKEEI TQRHIQQVAL GISENMAVPL MPDQQEEKLR SQLEEEKRRY KTMFTRLKAL
KVEIEHLQLL MDKAKVKLQK EFEVWWAEEA TNLQVNSPAV NSLDHTKPFL QTSDSQHEWS
QLLSNKSSGG WEVQDQGTGR FDVCDVNARK ILPSPCPSPH SQKQSSTSTP LEDSIPKRPV
SSIPLTGDSQ TDSDIIAFIK ARQSILQKQC LGSN
