位置:首页 > 蛋白库 > KIF9_DICDI
KIF9_DICDI
ID   KIF9_DICDI              Reviewed;        1222 AA.
AC   Q555I8; Q86HL6; Q86SA4;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Kinesin-related protein 9;
DE   AltName: Full=Kinesin family member 9;
GN   Name=kif9; Synonyms=kin2; ORFNames=DDB_G0274603;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Suyama E., Sutoh K.;
RT   "Kinesin-related proteins from Dictyostelium.";
RL   Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [4]
RP   IDENTIFICATION, AND NOMENCLATURE.
RX   PubMed=14641909; DOI=10.1186/1471-2164-4-47;
RA   Kollmar M., Gloeckner G.;
RT   "Identification and phylogenetic analysis of Dictyostelium discoideum
RT   kinesin proteins.";
RL   BMC Genomics 4:47-47(2003).
CC   -!- FUNCTION: Microtubule-associated force-producing protein that plays a
CC       role in organelle transport. Its motor activity is directed toward the
CC       microtubule's plus end (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}. Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC       superfamily. Kinesin family. {ECO:0000255|PROSITE-ProRule:PRU00283}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB102779; BAC56911.1; -; mRNA.
DR   EMBL; AAFI02000012; EAL70194.1; -; Genomic_DNA.
DR   RefSeq; XP_644079.1; XM_638987.1.
DR   AlphaFoldDB; Q555I8; -.
DR   SMR; Q555I8; -.
DR   STRING; 44689.DDB0185204; -.
DR   TCDB; 1.I.1.1.5; the nuclear pore complex (npc) family.
DR   PaxDb; Q555I8; -.
DR   EnsemblProtists; EAL70194; EAL70194; DDB_G0274603.
DR   GeneID; 8619508; -.
DR   KEGG; ddi:DDB_G0274603; -.
DR   dictyBase; DDB_G0274603; kif9.
DR   eggNOG; KOG0240; Eukaryota.
DR   HOGENOM; CLU_268575_0_0_1; -.
DR   InParanoid; Q555I8; -.
DR   OMA; ICINILF; -.
DR   PhylomeDB; Q555I8; -.
DR   PRO; PR:Q555I8; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005871; C:kinesin complex; IBA:GO_Central.
DR   GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR   GO; GO:0005635; C:nuclear envelope; IDA:dictyBase.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:0008017; F:microtubule binding; IDA:dictyBase.
DR   GO; GO:0003777; F:microtubule motor activity; IBA:GO_Central.
DR   GO; GO:0007098; P:centrosome cycle; IMP:dictyBase.
DR   GO; GO:0051661; P:maintenance of centrosome location; IMP:dictyBase.
DR   GO; GO:0007019; P:microtubule depolymerization; IDA:dictyBase.
DR   GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central.
DR   GO; GO:0000278; P:mitotic cell cycle; IMP:dictyBase.
DR   Gene3D; 3.40.850.10; -; 1.
DR   InterPro; IPR027640; Kinesin-like_fam.
DR   InterPro; IPR001752; Kinesin_motor_dom.
DR   InterPro; IPR036961; Kinesin_motor_dom_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR24115; PTHR24115; 1.
DR   Pfam; PF00225; Kinesin; 1.
DR   PRINTS; PR00380; KINESINHEAVY.
DR   SMART; SM00129; KISc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Coiled coil; Cytoplasm; Cytoskeleton; Membrane; Microtubule;
KW   Motor protein; Nucleotide-binding; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..1222
FT                   /note="Kinesin-related protein 9"
FT                   /id="PRO_0000365584"
FT   TRANSMEM        1183..1203
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          350..719
FT                   /note="Kinesin motor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00283"
FT   REGION          1..55
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          75..165
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          188..343
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1144..1174
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          724..1026
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        75..98
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        121..165
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         438..445
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00283"
FT   CONFLICT        935
FT                   /note="E -> V (in Ref. 1; BAC56911)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1222 AA;  136066 MW;  2C14E8F6F00D5E39 CRC64;
     MDNNNNNFST PKQPTINSTT GGQLRSRSNS SPSTSSISTP RNGSTTATTS SITNSIGKGS
     LVFSTMENAK KTLNMDSLST PMSQSSKKRL SMNSSLLPPS SIPLPPSQQL SAKKDPSKRH
     SSFISTTTTT SLGSRPSTPQ PNHTTNNNNN NNNGSNGNNV TSTNISSMLE SNNSEILSQN
     QKVTLSTSSN TAFSSLPSST NNGNNPLSNS GGGNGNHHLV NSNSSTSTPS PTMFISTTSP
     PPELSLMEGF NQHNLTTTTT TTTTTTNNTL NTSNGINSNS LSPSSHLNNG SNNNNNNNHL
     NLNNRSSSPS PTPSSSSISG RRTPIQNFNS VGGVNITSKT QPLFSDREES IQAVCRFRPE
     TAAEQTLGPS EKQLTIGTDQ TTIHITPTSS SSSSMAQAFR FSKVYQPNTT QESFYNEVGK
     PLIDNIVNGY NVGIIAYGQT GAGKTFSLGF SGGEGNDSYN SYCNRSEFYN NSHYLYGSQQ
     QQQQQQLLPS SWGIMPRIIK DLFIKQDEQQ SMNTPQRIKF TTKISYLEVY KEKVYDLLSE
     GGVNDIEIRM ADGGFIVPDA VQSSIQTFTD FLTHLQHIEK NRKIAETKKN MASSRSHAIF
     IVSLLKEDLE NKMTVTSLLY LVDLAGSESA SKIDGTTSKI EETKSINKSL YALGGVIEDM
     SKNSKHVRYR DSKLTQLLQQ CFGGNSKTCL IVNCSSSNHE SVIRETIQSL NFGQRAQSVK
     NKPLQNVEES HSELKAKLRE LNKDIETYKK FIEKISINSG VIPPSSVATY ITQLQNACEE
     LKKKNDRLQE DIINLEEENS DLPKKFNVLN KNNVSQIEIL TQELELSKQI NQEQLLKIEQ
     YSQKYQATNE EIQKSFNHRQ QLVNDLHDSN EKSKQLELKL KDALLNSKSE SDEIRLKLTK
     ALEESTDKDQ RINTLESNKQ KWKSKCNEVV RQSKELQDRL NILQSTYSNS VDSLSNSSLN
     NNNNESLEEI KKLKLNISSL TNQHIEREKS LQKEIDLARS KHTEQTLILK NLKTQIDTLT
     NKLEIQFPTI VNNNQQQQQS TQSSSSSSIE SNLIISMNTI EVLFEKICKN QEQTNTIIST
     NVESIMGKLV EIDENEEFIR KEKDRERERA ENLKNTLEDA QSNFLKQQEE IKQFIETQLK
     NKNNINNNNN IKNNNNNNKL KSKKVGSSSS SSSNIGSSIC INILFFLIIL VILFFLMVAV
     GLTIQNQDYN SQYRSSYFFK TT
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024