KIFC2_HUMAN
ID KIFC2_HUMAN Reviewed; 838 AA.
AC Q96AC6; E9PHB2; Q96NN6;
DT 15-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Kinesin-like protein KIFC2;
GN Name=KIFC2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May play a role in microtubule-dependent retrograde axonal
CC transport. May function as the motor for the transport of
CC multivesicular body (MVB)-like organelles in dendrites (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q96AC6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96AC6-2; Sequence=VSP_056102, VSP_056103, VSP_056104;
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000255|PROSITE-ProRule:PRU00283}.
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DR EMBL; AK055045; BAB70844.1; -; mRNA.
DR EMBL; AC084125; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471162; EAW82085.1; -; Genomic_DNA.
DR EMBL; BC017311; AAH17311.1; -; mRNA.
DR CCDS; CCDS6427.1; -. [Q96AC6-1]
DR RefSeq; NP_665697.1; NM_145754.3. [Q96AC6-1]
DR AlphaFoldDB; Q96AC6; -.
DR SMR; Q96AC6; -.
DR BioGRID; 124785; 4.
DR IntAct; Q96AC6; 9.
DR MINT; Q96AC6; -.
DR STRING; 9606.ENSP00000301332; -.
DR iPTMnet; Q96AC6; -.
DR PhosphoSitePlus; Q96AC6; -.
DR BioMuta; KIFC2; -.
DR DMDM; 34098674; -.
DR EPD; Q96AC6; -.
DR jPOST; Q96AC6; -.
DR MassIVE; Q96AC6; -.
DR PaxDb; Q96AC6; -.
DR PeptideAtlas; Q96AC6; -.
DR PRIDE; Q96AC6; -.
DR ProteomicsDB; 75953; -. [Q96AC6-1]
DR ProteomicsDB; 77539; -.
DR Antibodypedia; 14932; 74 antibodies from 20 providers.
DR DNASU; 90990; -.
DR Ensembl; ENST00000301332.3; ENSP00000301332.2; ENSG00000167702.13. [Q96AC6-1]
DR GeneID; 90990; -.
DR KEGG; hsa:90990; -.
DR UCSC; uc003zcz.4; human. [Q96AC6-1]
DR CTD; 90990; -.
DR DisGeNET; 90990; -.
DR GeneCards; KIFC2; -.
DR HGNC; HGNC:29530; KIFC2.
DR HPA; ENSG00000167702; Tissue enhanced (brain).
DR MIM; 615216; gene.
DR neXtProt; NX_Q96AC6; -.
DR OpenTargets; ENSG00000167702; -.
DR PharmGKB; PA134874212; -.
DR VEuPathDB; HostDB:ENSG00000167702; -.
DR eggNOG; KOG0239; Eukaryota.
DR GeneTree; ENSGT00940000154022; -.
DR HOGENOM; CLU_001485_12_6_1; -.
DR InParanoid; Q96AC6; -.
DR OrthoDB; 364605at2759; -.
DR PhylomeDB; Q96AC6; -.
DR TreeFam; TF105238; -.
DR PathwayCommons; Q96AC6; -.
DR Reactome; R-HSA-6811434; COPI-dependent Golgi-to-ER retrograde traffic.
DR Reactome; R-HSA-983189; Kinesins.
DR SignaLink; Q96AC6; -.
DR BioGRID-ORCS; 90990; 124 hits in 1083 CRISPR screens.
DR ChiTaRS; KIFC2; human.
DR GenomeRNAi; 90990; -.
DR Pharos; Q96AC6; Tbio.
DR PRO; PR:Q96AC6; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q96AC6; protein.
DR Bgee; ENSG00000167702; Expressed in right hemisphere of cerebellum and 162 other tissues.
DR ExpressionAtlas; Q96AC6; baseline and differential.
DR Genevisible; Q96AC6; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005871; C:kinesin complex; IBA:GO_Central.
DR GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR GO; GO:0005815; C:microtubule organizing center; IBA:GO_Central.
DR GO; GO:0072686; C:mitotic spindle; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0003777; F:microtubule motor activity; IBA:GO_Central.
DR GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central.
DR GO; GO:0090307; P:mitotic spindle assembly; IBA:GO_Central.
DR Gene3D; 3.40.850.10; -; 1.
DR InterPro; IPR027640; Kinesin-like_fam.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24115; PTHR24115; 1.
DR Pfam; PF00225; Kinesin; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; ATP-binding; Coiled coil; Cytoplasm; Cytoskeleton;
KW Microtubule; Motor protein; Nucleotide-binding; Reference proteome.
FT CHAIN 1..838
FT /note="Kinesin-like protein KIFC2"
FT /id="PRO_0000125429"
FT DOMAIN 409..740
FT /note="Kinesin motor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00283"
FT REGION 23..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 140..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 718..792
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 186..351
FT /evidence="ECO:0000255"
FT COMPBIAS 741..756
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 484..491
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00283"
FT VAR_SEQ 1..252
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_056102"
FT VAR_SEQ 523..551
FT /note="VTLSMVEIYNEAVRDLLAPGPPERLAVRQ -> RYHGRCLSPAESPEHPRPG
FT LPPCRARSPL (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_056103"
FT VAR_SEQ 552..838
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_056104"
FT VARIANT 67
FT /note="G -> E (in dbSNP:rs35817880)"
FT /id="VAR_049684"
FT VARIANT 166
FT /note="S -> F (in dbSNP:rs12675537)"
FT /id="VAR_049685"
SQ SEQUENCE 838 AA; 90147 MW; 5C692E0B67A0BE77 CRC64;
MYAFYSLLIY IFYSLFRRDG GAAAAAEPGD PAQRARKPRG RRRPDLPAPE LWTELTGLAA
SSEPEDGSEG AAEGRAAAVS LEEALLRLAE FLSVQLGAEE SCGGPADLGQ SGEVPSLLTV
TSQLLALLAW LRSPRGRQAL LQGTQPAPRV RPPSPDGSTS QEESPSHFTA VPGEPLGDET
QGQQPLQLEE DQRAWQRLEQ LILGQLEELK QQLEQQEEEL GRLRLGVGAT DSEKRVQHLT
LENEALKQSL SLMRDLLLHW GPGPPIRAPQ EEAEALLELQ GRLQEAQDTT EALRAQLGVQ
EVQLQGLQGA LQQLQQETEQ NCRRELQQMH GQLAGLRARM ASLRQGCGDL RGLVSTFTQS
CQGSLSEARG QVSWALGALS SGGPGTQLPE GQQGPPAGCP GRLPELKGNI RVLCRLRPGT
SSSLVSVEPG PGGTVTTCYR GRHRRFRLDW VFPPDASQEE VFRELEPAVL SCLRGYSVCI
FTYGQTGTGK TYSMEGPPED PGIVPRALQS LFREMGAGRQ HRVTLSMVEI YNEAVRDLLA
PGPPERLAVR QGPEGQGGIQ VAGLTHWDVP NLETLHQMLK LGRSNRATAA TAMNQRSSRS
HALVTLTLRA ASPPRAPGTA GTLHLVDLAG SERARKAGAA GPPRGDPDGA RRLREAQTIN
RSLLALGGVM AALRAHRPHV PFRDSQLTRL LQPALGPGTT AVLLLQVGAG AGQVCACRSP
PTRARPPAPL ARRSPRGRRI SGRQSAPSSS PTEWVKWSWG QPGAAGSRAP PGRLLPSAPT
LRSPGPPAPL RRPLAVLHAP VPTTARARLS RPQRACPSSP GSRPCPWGLR PGLCWQRR
