KIFC3_HUMAN
ID KIFC3_HUMAN Reviewed; 833 AA.
AC Q9BVG8; A8K6S2; B7Z484; O75299; Q49A29; Q49AQ0; Q59G19; Q8IUT3; Q96HW6;
DT 15-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 16-NOV-2011, sequence version 4.
DT 03-AUG-2022, entry version 187.
DE RecName: Full=Kinesin-like protein KIFC3;
GN Name=KIFC3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 5).
RC TISSUE=Placenta, and Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RA Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.,
RA Ohara O., Nagase T., Kikuno R.F.;
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 105-833 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE
RP MRNA] OF 106-833 (ISOFORM 3), AND VARIANT VAL-391.
RC TISSUE=Brain, Muscle, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 86-833 (ISOFORM 2).
RC TISSUE=Retina;
RX PubMed=9782090; DOI=10.1006/geno.1998.5431;
RA Hoang E.H., Whitehead J.L., Dose A.C., Burnside B.;
RT "Cloning of a novel C-terminal kinesin (KIFC3) that maps to human
RT chromosome 16q13-q21 and thus is a candidate gene for Bardet-Biedl
RT syndrome.";
RL Genomics 52:219-222(1998).
RN [7]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=19041755; DOI=10.1016/j.cell.2008.09.040;
RA Meng W., Mushika Y., Ichii T., Takeichi M.;
RT "Anchorage of microtubule minus ends to adherens junctions regulates
RT epithelial cell-cell contacts.";
RL Cell 135:948-959(2008).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-813 AND SER-817, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [9]
RP X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 443-770 IN COMPLEX WITH ADP.
RG Structural genomics consortium (SGC);
RT "Crystal structure of the KIFC3 motor domain in complex with ADP.";
RL Submitted (JUN-2006) to the PDB data bank.
CC -!- FUNCTION: Minus-end microtubule-dependent motor protein. Involved in
CC apically targeted transport (By similarity). Required for zonula
CC adherens maintenance. {ECO:0000250, ECO:0000269|PubMed:19041755}.
CC -!- INTERACTION:
CC Q9BVG8; Q9NYB9: ABI2; NbExp=5; IntAct=EBI-2125614, EBI-743598;
CC Q9BVG8; P15336: ATF2; NbExp=3; IntAct=EBI-2125614, EBI-1170906;
CC Q9BVG8; P41182: BCL6; NbExp=3; IntAct=EBI-2125614, EBI-765407;
CC Q9BVG8; Q9NX04: C1orf109; NbExp=4; IntAct=EBI-2125614, EBI-8643161;
CC Q9BVG8; Q9HC52: CBX8; NbExp=3; IntAct=EBI-2125614, EBI-712912;
CC Q9BVG8; Q8NA61: CBY2; NbExp=5; IntAct=EBI-2125614, EBI-741724;
CC Q9BVG8; Q68D86: CCDC102B; NbExp=3; IntAct=EBI-2125614, EBI-10171570;
CC Q9BVG8; Q96JN2-2: CCDC136; NbExp=3; IntAct=EBI-2125614, EBI-10171416;
CC Q9BVG8; Q7Z6N9: CCDC28A; NbExp=3; IntAct=EBI-2125614, EBI-10258115;
CC Q9BVG8; Q8IWP9: CCDC28A; NbExp=3; IntAct=EBI-2125614, EBI-355471;
CC Q9BVG8; Q07002: CDK18; NbExp=3; IntAct=EBI-2125614, EBI-746238;
CC Q9BVG8; Q01850: CDR2; NbExp=3; IntAct=EBI-2125614, EBI-1181367;
CC Q9BVG8; Q96L14: CEP170P1; NbExp=4; IntAct=EBI-2125614, EBI-743488;
CC Q9BVG8; Q53EZ4: CEP55; NbExp=3; IntAct=EBI-2125614, EBI-747776;
CC Q9BVG8; Q8IYX8-2: CEP57L1; NbExp=3; IntAct=EBI-2125614, EBI-10181988;
CC Q9BVG8; Q8N3C7: CLIP4; NbExp=3; IntAct=EBI-2125614, EBI-5655540;
CC Q9BVG8; Q02930-3: CREB5; NbExp=3; IntAct=EBI-2125614, EBI-10192698;
CC Q9BVG8; Q8WWE8: CYTH4; NbExp=3; IntAct=EBI-2125614, EBI-10277443;
CC Q9BVG8; Q13561: DCTN2; NbExp=3; IntAct=EBI-2125614, EBI-715074;
CC Q9BVG8; O43602: DCX; NbExp=3; IntAct=EBI-2125614, EBI-8646694;
CC Q9BVG8; Q05D60: DEUP1; NbExp=3; IntAct=EBI-2125614, EBI-748597;
CC Q9BVG8; Q96EV8: DTNBP1; NbExp=3; IntAct=EBI-2125614, EBI-465804;
CC Q9BVG8; P62508: ESRRG; NbExp=3; IntAct=EBI-2125614, EBI-2834260;
CC Q9BVG8; Q86V42: FAM124A; NbExp=3; IntAct=EBI-2125614, EBI-744506;
CC Q9BVG8; Q9NW38: FANCL; NbExp=3; IntAct=EBI-2125614, EBI-2339898;
CC Q9BVG8; O94868: FCHSD2; NbExp=3; IntAct=EBI-2125614, EBI-1215612;
CC Q9BVG8; Q53SE7: FLJ13057; NbExp=3; IntAct=EBI-2125614, EBI-10172181;
CC Q9BVG8; Q08379: GOLGA2; NbExp=3; IntAct=EBI-2125614, EBI-618309;
CC Q9BVG8; Q9H8Y8: GORASP2; NbExp=3; IntAct=EBI-2125614, EBI-739467;
CC Q9BVG8; Q96CS2: HAUS1; NbExp=3; IntAct=EBI-2125614, EBI-2514791;
CC Q9BVG8; O75506: HSBP1; NbExp=5; IntAct=EBI-2125614, EBI-748664;
CC Q9BVG8; Q8NDH6: ICA1L; NbExp=3; IntAct=EBI-2125614, EBI-10269733;
CC Q9BVG8; Q13352: ITGB3BP; NbExp=3; IntAct=EBI-2125614, EBI-712105;
CC Q9BVG8; Q13352-5: ITGB3BP; NbExp=3; IntAct=EBI-2125614, EBI-10175826;
CC Q9BVG8; Q7Z3B3: KANSL1; NbExp=4; IntAct=EBI-2125614, EBI-740244;
CC Q9BVG8; P19012: KRT15; NbExp=3; IntAct=EBI-2125614, EBI-739566;
CC Q9BVG8; P08727: KRT19; NbExp=3; IntAct=EBI-2125614, EBI-742756;
CC Q9BVG8; Q15323: KRT31; NbExp=3; IntAct=EBI-2125614, EBI-948001;
CC Q9BVG8; Q6A162: KRT40; NbExp=3; IntAct=EBI-2125614, EBI-10171697;
CC Q9BVG8; P13647: KRT5; NbExp=3; IntAct=EBI-2125614, EBI-702187;
CC Q9BVG8; P02538: KRT6A; NbExp=5; IntAct=EBI-2125614, EBI-702198;
CC Q9BVG8; P04259: KRT6B; NbExp=3; IntAct=EBI-2125614, EBI-740907;
CC Q9BVG8; P48668: KRT6C; NbExp=3; IntAct=EBI-2125614, EBI-2564105;
CC Q9BVG8; Q96BZ8: LENG1; NbExp=3; IntAct=EBI-2125614, EBI-726510;
CC Q9BVG8; Q96GY3: LIN37; NbExp=3; IntAct=EBI-2125614, EBI-748884;
CC Q9BVG8; Q9BRK4: LZTS2; NbExp=3; IntAct=EBI-2125614, EBI-741037;
CC Q9BVG8; P33993: MCM7; NbExp=3; IntAct=EBI-2125614, EBI-355924;
CC Q9BVG8; Q9NPJ6: MED4; NbExp=3; IntAct=EBI-2125614, EBI-394607;
CC Q9BVG8; P55081: MFAP1; NbExp=3; IntAct=EBI-2125614, EBI-1048159;
CC Q9BVG8; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-2125614, EBI-10172526;
CC Q9BVG8; P00540: MOS; NbExp=3; IntAct=EBI-2125614, EBI-1757866;
CC Q9BVG8; Q9GZM8: NDEL1; NbExp=3; IntAct=EBI-2125614, EBI-928842;
CC Q9BVG8; Q7Z6G3-2: NECAB2; NbExp=3; IntAct=EBI-2125614, EBI-10172876;
CC Q9BVG8; I6L9F6: NEFL; NbExp=3; IntAct=EBI-2125614, EBI-10178578;
CC Q9BVG8; P37198: NUP62; NbExp=3; IntAct=EBI-2125614, EBI-347978;
CC Q9BVG8; Q8IXK0: PHC2; NbExp=3; IntAct=EBI-2125614, EBI-713786;
CC Q9BVG8; P54646: PRKAA2; NbExp=4; IntAct=EBI-2125614, EBI-1383852;
CC Q9BVG8; P20618: PSMB1; NbExp=4; IntAct=EBI-2125614, EBI-372273;
CC Q9BVG8; O75771: RAD51D; NbExp=4; IntAct=EBI-2125614, EBI-1055693;
CC Q9BVG8; Q9UHP6: RSPH14; NbExp=3; IntAct=EBI-2125614, EBI-748350;
CC Q9BVG8; O95171: SCEL; NbExp=3; IntAct=EBI-2125614, EBI-7543896;
CC Q9BVG8; Q8IUQ4: SIAH1; NbExp=3; IntAct=EBI-2125614, EBI-747107;
CC Q9BVG8; Q969G3: SMARCE1; NbExp=4; IntAct=EBI-2125614, EBI-455078;
CC Q9BVG8; P35711: SOX5; NbExp=3; IntAct=EBI-2125614, EBI-3505701;
CC Q9BVG8; Q8N0S2: SYCE1; NbExp=3; IntAct=EBI-2125614, EBI-6872807;
CC Q9BVG8; Q8N8B7: TCEANC; NbExp=3; IntAct=EBI-2125614, EBI-954696;
CC Q9BVG8; Q08117: TLE5; NbExp=3; IntAct=EBI-2125614, EBI-717810;
CC Q9BVG8; Q15025: TNIP1; NbExp=3; IntAct=EBI-2125614, EBI-357849;
CC Q9BVG8; Q5VU62: TPM3; NbExp=3; IntAct=EBI-2125614, EBI-10184033;
CC Q9BVG8; Q12933: TRAF2; NbExp=3; IntAct=EBI-2125614, EBI-355744;
CC Q9BVG8; P36406: TRIM23; NbExp=3; IntAct=EBI-2125614, EBI-740098;
CC Q9BVG8; P14373: TRIM27; NbExp=3; IntAct=EBI-2125614, EBI-719493;
CC Q9BVG8; Q8WV44: TRIM41; NbExp=3; IntAct=EBI-2125614, EBI-725997;
CC Q9BVG8; Q9BYV2: TRIM54; NbExp=3; IntAct=EBI-2125614, EBI-2130429;
CC Q9BVG8; Q99816: TSG101; NbExp=3; IntAct=EBI-2125614, EBI-346882;
CC Q9BVG8; Q969E8: TSR2; NbExp=3; IntAct=EBI-2125614, EBI-746981;
CC Q9BVG8; O75604: USP2; NbExp=3; IntAct=EBI-2125614, EBI-743272;
CC Q9BVG8; Q96BR9: ZBTB8A; NbExp=3; IntAct=EBI-2125614, EBI-742740;
CC Q9BVG8; Q8N5A5: ZGPAT; NbExp=4; IntAct=EBI-2125614, EBI-3439227;
CC Q9BVG8; Q8N5A5-2: ZGPAT; NbExp=3; IntAct=EBI-2125614, EBI-10183064;
CC Q9BVG8; Q9UJW8: ZNF180; NbExp=3; IntAct=EBI-2125614, EBI-10322527;
CC Q9BVG8; P17024: ZNF20; NbExp=3; IntAct=EBI-2125614, EBI-717634;
CC Q9BVG8; Q7Z3I7: ZNF572; NbExp=6; IntAct=EBI-2125614, EBI-10172590;
CC Q9BVG8; Q8N720: ZNF655; NbExp=3; IntAct=EBI-2125614, EBI-625509;
CC Q9BVG8-5; Q9NYB9-2: ABI2; NbExp=3; IntAct=EBI-14069005, EBI-11096309;
CC Q9BVG8-5; Q9P2A4: ABI3; NbExp=3; IntAct=EBI-14069005, EBI-742038;
CC Q9BVG8-5; Q86SG2: ANKRD23; NbExp=3; IntAct=EBI-14069005, EBI-5661893;
CC Q9BVG8-5; Q8NEU8: APPL2; NbExp=3; IntAct=EBI-14069005, EBI-741261;
CC Q9BVG8-5; P15336: ATF2; NbExp=3; IntAct=EBI-14069005, EBI-1170906;
CC Q9BVG8-5; Q9Y2T1: AXIN2; NbExp=3; IntAct=EBI-14069005, EBI-4400025;
CC Q9BVG8-5; Q99728: BARD1; NbExp=3; IntAct=EBI-14069005, EBI-473181;
CC Q9BVG8-5; Q9BUH8: BEGAIN; NbExp=3; IntAct=EBI-14069005, EBI-742722;
CC Q9BVG8-5; Q12934-2: BFSP1; NbExp=3; IntAct=EBI-14069005, EBI-12123320;
CC Q9BVG8-5; Q13895: BYSL; NbExp=5; IntAct=EBI-14069005, EBI-358049;
CC Q9BVG8-5; Q9NX04: C1orf109; NbExp=3; IntAct=EBI-14069005, EBI-8643161;
CC Q9BVG8-5; Q53TS8: C2CD6; NbExp=3; IntAct=EBI-14069005, EBI-739879;
CC Q9BVG8-5; Q9H257-2: CARD9; NbExp=3; IntAct=EBI-14069005, EBI-11530605;
CC Q9BVG8-5; O43439-4: CBFA2T2; NbExp=3; IntAct=EBI-14069005, EBI-11954144;
CC Q9BVG8-5; Q9HC52: CBX8; NbExp=3; IntAct=EBI-14069005, EBI-712912;
CC Q9BVG8-5; Q8NA61-2: CBY2; NbExp=3; IntAct=EBI-14069005, EBI-11524851;
CC Q9BVG8-5; Q8IYE0: CCDC146; NbExp=3; IntAct=EBI-14069005, EBI-10749669;
CC Q9BVG8-5; E9PSE9: CCDC198; NbExp=3; IntAct=EBI-14069005, EBI-11748295;
CC Q9BVG8-5; Q8TD31-1: CCHCR1; NbExp=4; IntAct=EBI-14069005, EBI-21238948;
CC Q9BVG8-5; Q8TD31-3: CCHCR1; NbExp=3; IntAct=EBI-14069005, EBI-10175300;
CC Q9BVG8-5; P30281: CCND3; NbExp=3; IntAct=EBI-14069005, EBI-375013;
CC Q9BVG8-5; Q16543: CDC37; NbExp=3; IntAct=EBI-14069005, EBI-295634;
CC Q9BVG8-5; P38936: CDKN1A; NbExp=3; IntAct=EBI-14069005, EBI-375077;
CC Q9BVG8-5; Q01850: CDR2; NbExp=3; IntAct=EBI-14069005, EBI-1181367;
CC Q9BVG8-5; Q53EZ4: CEP55; NbExp=3; IntAct=EBI-14069005, EBI-747776;
CC Q9BVG8-5; Q8N3C7: CLIP4; NbExp=3; IntAct=EBI-14069005, EBI-5655540;
CC Q9BVG8-5; Q96JB2-2: COG3; NbExp=3; IntAct=EBI-14069005, EBI-9091495;
CC Q9BVG8-5; A0A0S2Z604: COG7; NbExp=3; IntAct=EBI-14069005, EBI-16430119;
CC Q9BVG8-5; P83436: COG7; NbExp=6; IntAct=EBI-14069005, EBI-389534;
CC Q9BVG8-5; Q02930-3: CREB5; NbExp=3; IntAct=EBI-14069005, EBI-10192698;
CC Q9BVG8-5; Q2TBE0: CWF19L2; NbExp=3; IntAct=EBI-14069005, EBI-5453285;
CC Q9BVG8-5; Q13561: DCTN2; NbExp=3; IntAct=EBI-14069005, EBI-715074;
CC Q9BVG8-5; Q05D60: DEUP1; NbExp=5; IntAct=EBI-14069005, EBI-748597;
CC Q9BVG8-5; Q9NRI5-2: DISC1; NbExp=3; IntAct=EBI-14069005, EBI-11988027;
CC Q9BVG8-5; O15371: EIF3D; NbExp=3; IntAct=EBI-14069005, EBI-353818;
CC Q9BVG8-5; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-14069005, EBI-744099;
CC Q9BVG8-5; O00471: EXOC5; NbExp=3; IntAct=EBI-14069005, EBI-949824;
CC Q9BVG8-5; Q9UPT5-1: EXOC7; NbExp=3; IntAct=EBI-14069005, EBI-6251402;
CC Q9BVG8-5; Q8IYI6: EXOC8; NbExp=3; IntAct=EBI-14069005, EBI-742102;
CC Q9BVG8-5; Q3B820: FAM161A; NbExp=3; IntAct=EBI-14069005, EBI-719941;
CC Q9BVG8-5; Q86YD7: FAM90A1; NbExp=3; IntAct=EBI-14069005, EBI-6658203;
CC Q9BVG8-5; Q9NW38: FANCL; NbExp=3; IntAct=EBI-14069005, EBI-2339898;
CC Q9BVG8-5; Q9BSK4: FEM1A; NbExp=3; IntAct=EBI-14069005, EBI-2515349;
CC Q9BVG8-5; P22607: FGFR3; NbExp=3; IntAct=EBI-14069005, EBI-348399;
CC Q9BVG8-5; Q4VC44: FLYWCH1; NbExp=3; IntAct=EBI-14069005, EBI-719415;
CC Q9BVG8-5; P15407: FOSL1; NbExp=3; IntAct=EBI-14069005, EBI-744510;
CC Q9BVG8-5; Q8TAE8: GADD45GIP1; NbExp=3; IntAct=EBI-14069005, EBI-372506;
CC Q9BVG8-5; P55040: GEM; NbExp=3; IntAct=EBI-14069005, EBI-744104;
CC Q9BVG8-5; P14136: GFAP; NbExp=3; IntAct=EBI-14069005, EBI-744302;
CC Q9BVG8-5; O75420: GIGYF1; NbExp=3; IntAct=EBI-14069005, EBI-947774;
CC Q9BVG8-5; Q96IK5: GMCL1; NbExp=3; IntAct=EBI-14069005, EBI-2548508;
CC Q9BVG8-5; Q92805: GOLGA1; NbExp=3; IntAct=EBI-14069005, EBI-6164177;
CC Q9BVG8-5; Q08379: GOLGA2; NbExp=3; IntAct=EBI-14069005, EBI-618309;
CC Q9BVG8-5; Q9H8Y8: GORASP2; NbExp=3; IntAct=EBI-14069005, EBI-739467;
CC Q9BVG8-5; A0A024R8L2: hCG_1987119; NbExp=3; IntAct=EBI-14069005, EBI-14103818;
CC Q9BVG8-5; Q9NP66: HMG20A; NbExp=3; IntAct=EBI-14069005, EBI-740641;
CC Q9BVG8-5; P01112: HRAS; NbExp=3; IntAct=EBI-14069005, EBI-350145;
CC Q9BVG8-5; O75506: HSBP1; NbExp=3; IntAct=EBI-14069005, EBI-748664;
CC Q9BVG8-5; O75031: HSF2BP; NbExp=3; IntAct=EBI-14069005, EBI-7116203;
CC Q9BVG8-5; Q86VF2-5: IGFN1; NbExp=3; IntAct=EBI-14069005, EBI-11955401;
CC Q9BVG8-5; Q8IYA8: IHO1; NbExp=3; IntAct=EBI-14069005, EBI-8638439;
CC Q9BVG8-5; Q9UKT9: IKZF3; NbExp=3; IntAct=EBI-14069005, EBI-747204;
CC Q9BVG8-5; Q14005-2: IL16; NbExp=3; IntAct=EBI-14069005, EBI-17178971;
CC Q9BVG8-5; Q8NA54: IQUB; NbExp=3; IntAct=EBI-14069005, EBI-10220600;
CC Q9BVG8-5; Q13352: ITGB3BP; NbExp=3; IntAct=EBI-14069005, EBI-712105;
CC Q9BVG8-5; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-14069005, EBI-2556193;
CC Q9BVG8-5; O60341: KDM1A; NbExp=3; IntAct=EBI-14069005, EBI-710124;
CC Q9BVG8-5; Q2KHM9: KIAA0753; NbExp=3; IntAct=EBI-14069005, EBI-2805604;
CC Q9BVG8-5; Q9BVG8-5: KIFC3; NbExp=3; IntAct=EBI-14069005, EBI-14069005;
CC Q9BVG8-5; O14901: KLF11; NbExp=3; IntAct=EBI-14069005, EBI-948266;
CC Q9BVG8-5; P02533: KRT14; NbExp=3; IntAct=EBI-14069005, EBI-702178;
CC Q9BVG8-5; P19012: KRT15; NbExp=3; IntAct=EBI-14069005, EBI-739566;
CC Q9BVG8-5; P08779: KRT16; NbExp=3; IntAct=EBI-14069005, EBI-356410;
CC Q9BVG8-5; P05783: KRT18; NbExp=3; IntAct=EBI-14069005, EBI-297888;
CC Q9BVG8-5; Q7Z3Y9: KRT26; NbExp=3; IntAct=EBI-14069005, EBI-12084444;
CC Q9BVG8-5; P12035: KRT3; NbExp=3; IntAct=EBI-14069005, EBI-2430095;
CC Q9BVG8-5; Q15323: KRT31; NbExp=3; IntAct=EBI-14069005, EBI-948001;
CC Q9BVG8-5; Q14532: KRT32; NbExp=3; IntAct=EBI-14069005, EBI-1044146;
CC Q9BVG8-5; Q92764: KRT35; NbExp=3; IntAct=EBI-14069005, EBI-1058674;
CC Q9BVG8-5; O76015: KRT38; NbExp=3; IntAct=EBI-14069005, EBI-1047263;
CC Q9BVG8-5; P13647: KRT5; NbExp=3; IntAct=EBI-14069005, EBI-702187;
CC Q9BVG8-5; P02538: KRT6A; NbExp=3; IntAct=EBI-14069005, EBI-702198;
CC Q9BVG8-5; P04259: KRT6B; NbExp=3; IntAct=EBI-14069005, EBI-740907;
CC Q9BVG8-5; P48668: KRT6C; NbExp=3; IntAct=EBI-14069005, EBI-2564105;
CC Q9BVG8-5; O95678: KRT75; NbExp=3; IntAct=EBI-14069005, EBI-2949715;
CC Q9BVG8-5; Q01546: KRT76; NbExp=3; IntAct=EBI-14069005, EBI-2952745;
CC Q9BVG8-5; Q3LI72: KRTAP19-5; NbExp=3; IntAct=EBI-14069005, EBI-1048945;
CC Q9BVG8-5; Q3LI70: KRTAP19-6; NbExp=3; IntAct=EBI-14069005, EBI-12805508;
CC Q9BVG8-5; P52954: LBX1; NbExp=3; IntAct=EBI-14069005, EBI-20141748;
CC Q9BVG8-5; Q96BZ8: LENG1; NbExp=3; IntAct=EBI-14069005, EBI-726510;
CC Q9BVG8-5; Q8TBB1: LNX1; NbExp=3; IntAct=EBI-14069005, EBI-739832;
CC Q9BVG8-5; Q9Y250: LZTS1; NbExp=3; IntAct=EBI-14069005, EBI-1216080;
CC Q9BVG8-5; Q9BRK4: LZTS2; NbExp=3; IntAct=EBI-14069005, EBI-741037;
CC Q9BVG8-5; Q8WWY6: MBD3L1; NbExp=3; IntAct=EBI-14069005, EBI-12516603;
CC Q9BVG8-5; P23508: MCC; NbExp=3; IntAct=EBI-14069005, EBI-307531;
CC Q9BVG8-5; Q9NPJ6: MED4; NbExp=3; IntAct=EBI-14069005, EBI-394607;
CC Q9BVG8-5; P55081: MFAP1; NbExp=3; IntAct=EBI-14069005, EBI-1048159;
CC Q9BVG8-5; Q8IVT4: MGC50722; NbExp=3; IntAct=EBI-14069005, EBI-14086479;
CC Q9BVG8-5; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-14069005, EBI-10172526;
CC Q9BVG8-5; Q13064: MKRN3; NbExp=3; IntAct=EBI-14069005, EBI-2340269;
CC Q9BVG8-5; Q9Y605: MRFAP1; NbExp=3; IntAct=EBI-14069005, EBI-995714;
CC Q9BVG8-5; Q5JR59-3: MTUS2; NbExp=5; IntAct=EBI-14069005, EBI-11522433;
CC Q9BVG8-5; Q15742: NAB2; NbExp=3; IntAct=EBI-14069005, EBI-8641936;
CC Q9BVG8-5; O14777: NDC80; NbExp=3; IntAct=EBI-14069005, EBI-715849;
CC Q9BVG8-5; O76041: NEBL; NbExp=3; IntAct=EBI-14069005, EBI-2880203;
CC Q9BVG8-5; Q7Z6G3-2: NECAB2; NbExp=3; IntAct=EBI-14069005, EBI-10172876;
CC Q9BVG8-5; I6L9F6: NEFL; NbExp=3; IntAct=EBI-14069005, EBI-10178578;
CC Q9BVG8-5; P07196: NEFL; NbExp=3; IntAct=EBI-14069005, EBI-475646;
CC Q9BVG8-5; Q6X4W1-2: NSMF; NbExp=3; IntAct=EBI-14069005, EBI-12028784;
CC Q9BVG8-5; O15212: PFDN6; NbExp=3; IntAct=EBI-14069005, EBI-356973;
CC Q9BVG8-5; O75928-2: PIAS2; NbExp=3; IntAct=EBI-14069005, EBI-348567;
CC Q9BVG8-5; Q4G0R1: PIBF1; NbExp=3; IntAct=EBI-14069005, EBI-14066006;
CC Q9BVG8-5; Q13526: PIN1; NbExp=3; IntAct=EBI-14069005, EBI-714158;
CC Q9BVG8-5; Q96PV4: PNMA5; NbExp=3; IntAct=EBI-14069005, EBI-10171633;
CC Q9BVG8-5; Q96KQ4: PPP1R13B; NbExp=3; IntAct=EBI-14069005, EBI-1105153;
CC Q9BVG8-5; Q9NQX0: PRDM6; NbExp=3; IntAct=EBI-14069005, EBI-11320284;
CC Q9BVG8-5; Q99633: PRPF18; NbExp=3; IntAct=EBI-14069005, EBI-2798416;
CC Q9BVG8-5; Q8WWY3: PRPF31; NbExp=3; IntAct=EBI-14069005, EBI-1567797;
CC Q9BVG8-5; P41219: PRPH; NbExp=3; IntAct=EBI-14069005, EBI-752074;
CC Q9BVG8-5; P20618: PSMB1; NbExp=3; IntAct=EBI-14069005, EBI-372273;
CC Q9BVG8-5; P47224: RABIF; NbExp=3; IntAct=EBI-14069005, EBI-713992;
CC Q9BVG8-5; O75771: RAD51D; NbExp=3; IntAct=EBI-14069005, EBI-1055693;
CC Q9BVG8-5; Q9Y4B4: RAD54L2; NbExp=3; IntAct=EBI-14069005, EBI-948156;
CC Q9BVG8-5; Q96IZ5: RBM41; NbExp=3; IntAct=EBI-14069005, EBI-740773;
CC Q9BVG8-5; Q9UHP6: RSPH14; NbExp=3; IntAct=EBI-14069005, EBI-748350;
CC Q9BVG8-5; Q06455-2: RUNX1T1; NbExp=3; IntAct=EBI-14069005, EBI-11984663;
CC Q9BVG8-5; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-14069005, EBI-748391;
CC Q9BVG8-5; Q9UIL1-3: SCOC; NbExp=3; IntAct=EBI-14069005, EBI-10692913;
CC Q9BVG8-5; Q6ZSJ9: SHISA6; NbExp=3; IntAct=EBI-14069005, EBI-12037847;
CC Q9BVG8-5; O60504: SORBS3; NbExp=3; IntAct=EBI-14069005, EBI-741237;
CC Q9BVG8-5; P35711-4: SOX5; NbExp=3; IntAct=EBI-14069005, EBI-11954419;
CC Q9BVG8-5; Q9UM82: SPATA2; NbExp=3; IntAct=EBI-14069005, EBI-744066;
CC Q9BVG8-5; Q9H0A9-2: SPATC1L; NbExp=3; IntAct=EBI-14069005, EBI-11995806;
CC Q9BVG8-5; Q9Y2D8: SSX2IP; NbExp=3; IntAct=EBI-14069005, EBI-2212028;
CC Q9BVG8-5; Q9NZ72: STMN3; NbExp=3; IntAct=EBI-14069005, EBI-725557;
CC Q9BVG8-5; O75558: STX11; NbExp=7; IntAct=EBI-14069005, EBI-714135;
CC Q9BVG8-5; Q16623: STX1A; NbExp=3; IntAct=EBI-14069005, EBI-712466;
CC Q9BVG8-5; Q6PIF2: SYCE2; NbExp=3; IntAct=EBI-14069005, EBI-11958386;
CC Q9BVG8-5; Q5T7P8-2: SYT6; NbExp=3; IntAct=EBI-14069005, EBI-10246152;
CC Q9BVG8-5; Q96C24: SYTL4; NbExp=3; IntAct=EBI-14069005, EBI-747142;
CC Q9BVG8-5; Q5VWN6: TASOR2; NbExp=6; IntAct=EBI-14069005, EBI-745958;
CC Q9BVG8-5; Q9NU19: TBC1D22B; NbExp=3; IntAct=EBI-14069005, EBI-8787464;
CC Q9BVG8-5; Q9UBB9: TFIP11; NbExp=3; IntAct=EBI-14069005, EBI-1105213;
CC Q9BVG8-5; Q08117-2: TLE5; NbExp=3; IntAct=EBI-14069005, EBI-11741437;
CC Q9BVG8-5; Q15025: TNIP1; NbExp=3; IntAct=EBI-14069005, EBI-357849;
CC Q9BVG8-5; P19237: TNNI1; NbExp=3; IntAct=EBI-14069005, EBI-746692;
CC Q9BVG8-5; Q12933: TRAF2; NbExp=3; IntAct=EBI-14069005, EBI-355744;
CC Q9BVG8-5; Q14142: TRIM14; NbExp=3; IntAct=EBI-14069005, EBI-2820256;
CC Q9BVG8-5; Q9BYV2: TRIM54; NbExp=3; IntAct=EBI-14069005, EBI-2130429;
CC Q9BVG8-5; Q3SY00: TSGA10IP; NbExp=3; IntAct=EBI-14069005, EBI-10241197;
CC Q9BVG8-5; Q969E8: TSR2; NbExp=3; IntAct=EBI-14069005, EBI-746981;
CC Q9BVG8-5; Q495M9: USH1G; NbExp=3; IntAct=EBI-14069005, EBI-8601749;
CC Q9BVG8-5; O75604: USP2; NbExp=3; IntAct=EBI-14069005, EBI-743272;
CC Q9BVG8-5; P08670: VIM; NbExp=3; IntAct=EBI-14069005, EBI-353844;
CC Q9BVG8-5; Q8N1B4: VPS52; NbExp=3; IntAct=EBI-14069005, EBI-2799833;
CC Q9BVG8-5; Q9UPY6-2: WASF3; NbExp=3; IntAct=EBI-14069005, EBI-12026286;
CC Q9BVG8-5; O96006: ZBED1; NbExp=3; IntAct=EBI-14069005, EBI-740037;
CC Q9BVG8-5; Q05516: ZBTB16; NbExp=3; IntAct=EBI-14069005, EBI-711925;
CC Q9BVG8-5; Q96BR9: ZBTB8A; NbExp=3; IntAct=EBI-14069005, EBI-742740;
CC Q9BVG8-5; A0A0S2Z6H0: ZGPAT; NbExp=3; IntAct=EBI-14069005, EBI-16428984;
CC Q9BVG8-5; Q8N5A5-2: ZGPAT; NbExp=6; IntAct=EBI-14069005, EBI-10183064;
CC Q9BVG8-5; Q9UJW8-4: ZNF180; NbExp=3; IntAct=EBI-14069005, EBI-12055755;
CC Q9BVG8-5; P17024: ZNF20; NbExp=3; IntAct=EBI-14069005, EBI-717634;
CC Q9BVG8-5; P15622-3: ZNF250; NbExp=3; IntAct=EBI-14069005, EBI-10177272;
CC Q9BVG8-5; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-14069005, EBI-740727;
CC Q9BVG8-5; Q9NWS9-2: ZNF446; NbExp=3; IntAct=EBI-14069005, EBI-740232;
CC Q9BVG8-5; Q7Z3I7: ZNF572; NbExp=4; IntAct=EBI-14069005, EBI-10172590;
CC Q9BVG8-5; Q8N720: ZNF655; NbExp=3; IntAct=EBI-14069005, EBI-625509;
CC Q9BVG8-5; A0A0S2Z5X4: ZNF688; NbExp=3; IntAct=EBI-14069005, EBI-16429014;
CC Q9BVG8-5; Q6NX45: ZNF774; NbExp=3; IntAct=EBI-14069005, EBI-10251462;
CC Q9BVG8-5; A8K8V0: ZNF785; NbExp=3; IntAct=EBI-14069005, EBI-3925400;
CC Q9BVG8-5; Q9Y2P0: ZNF835; NbExp=3; IntAct=EBI-14069005, EBI-5667516;
CC Q9BVG8-5; Q9UGI0: ZRANB1; NbExp=3; IntAct=EBI-14069005, EBI-527853;
CC Q9BVG8-5; Q9Y649; NbExp=3; IntAct=EBI-14069005, EBI-25900580;
CC -!- SUBCELLULAR LOCATION: Cell junction, adherens junction
CC {ECO:0000269|PubMed:19041755}. Cytoplasm, cytoskeleton, microtubule
CC organizing center, centrosome {ECO:0000269|PubMed:19041755}.
CC Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein
CC {ECO:0000250}. Note=Apical cell membrane. On membrane organelles
CC immediately beneath the apical plasma membrane of renal tubular
CC epithelial cells. Localized in the distal tubules and loops of Henle in
CC the kidney, but not in the proximal tubules or the glomeruli, with
CC stronger staining in the apical area of these epithelial cells (By
CC similarity). Localizes along zonula adherens only at mature cell-cell
CC contacts. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1;
CC IsoId=Q9BVG8-3; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9BVG8-2; Sequence=VSP_021018;
CC Name=3;
CC IsoId=Q9BVG8-4; Sequence=VSP_022361, VSP_022362;
CC Name=4;
CC IsoId=Q9BVG8-5; Sequence=VSP_043724, VSP_021018;
CC Name=5;
CC IsoId=Q9BVG8-6; Sequence=VSP_057224, VSP_021018;
CC -!- MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000255|PROSITE-ProRule:PRU00283}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH34234.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
CC Sequence=AAH41132.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
CC Sequence=AAH47051.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
CC Sequence=BAD92527.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK291737; BAF84426.1; -; mRNA.
DR EMBL; AK296995; BAH12470.1; -; mRNA.
DR EMBL; AB209290; BAD92527.1; ALT_INIT; mRNA.
DR EMBL; AC010543; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC092118; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; FO082293; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471092; EAW82955.1; -; Genomic_DNA.
DR EMBL; BC001211; AAH01211.2; -; mRNA.
DR EMBL; BC008014; AAH08014.1; -; mRNA.
DR EMBL; BC034234; AAH34234.1; ALT_INIT; mRNA.
DR EMBL; BC041132; AAH41132.1; ALT_INIT; mRNA.
DR EMBL; BC047051; AAH47051.1; ALT_SEQ; mRNA.
DR EMBL; AF004426; AAC24153.1; -; mRNA.
DR CCDS; CCDS10789.2; -. [Q9BVG8-3]
DR CCDS; CCDS45493.1; -. [Q9BVG8-2]
DR CCDS; CCDS45494.1; -. [Q9BVG8-5]
DR CCDS; CCDS81989.1; -. [Q9BVG8-6]
DR RefSeq; NP_001123571.1; NM_001130099.1. [Q9BVG8-5]
DR RefSeq; NP_001123572.1; NM_001130100.1. [Q9BVG8-2]
DR RefSeq; NP_001305639.1; NM_001318710.1. [Q9BVG8-6]
DR RefSeq; NP_001305640.1; NM_001318711.1.
DR RefSeq; NP_001305641.1; NM_001318712.1.
DR RefSeq; NP_001305642.1; NM_001318713.1.
DR RefSeq; NP_001305643.1; NM_001318714.1. [Q9BVG8-5]
DR RefSeq; NP_001305644.1; NM_001318715.1. [Q9BVG8-5]
DR RefSeq; NP_005541.3; NM_005550.3. [Q9BVG8-3]
DR PDB; 5WDE; X-ray; 1.85 A; A=443-770.
DR PDBsum; 5WDE; -.
DR AlphaFoldDB; Q9BVG8; -.
DR SMR; Q9BVG8; -.
DR BioGRID; 110002; 252.
DR DIP; DIP-52406N; -.
DR IntAct; Q9BVG8; 251.
DR MINT; Q9BVG8; -.
DR STRING; 9606.ENSP00000368976; -.
DR ChEMBL; CHEMBL1075119; -.
DR iPTMnet; Q9BVG8; -.
DR PhosphoSitePlus; Q9BVG8; -.
DR BioMuta; KIFC3; -.
DR DMDM; 357529584; -.
DR EPD; Q9BVG8; -.
DR jPOST; Q9BVG8; -.
DR MassIVE; Q9BVG8; -.
DR MaxQB; Q9BVG8; -.
DR PaxDb; Q9BVG8; -.
DR PeptideAtlas; Q9BVG8; -.
DR PRIDE; Q9BVG8; -.
DR ProteomicsDB; 6579; -.
DR ProteomicsDB; 79201; -. [Q9BVG8-3]
DR ProteomicsDB; 79202; -. [Q9BVG8-2]
DR ProteomicsDB; 79203; -. [Q9BVG8-4]
DR ProteomicsDB; 79204; -. [Q9BVG8-5]
DR Antibodypedia; 15192; 98 antibodies from 25 providers.
DR DNASU; 3801; -.
DR Ensembl; ENST00000379655.8; ENSP00000368976.4; ENSG00000140859.16. [Q9BVG8-3]
DR Ensembl; ENST00000421376.6; ENSP00000396399.2; ENSG00000140859.16. [Q9BVG8-5]
DR Ensembl; ENST00000445690.7; ENSP00000401696.2; ENSG00000140859.16. [Q9BVG8-2]
DR Ensembl; ENST00000465878.6; ENSP00000454659.1; ENSG00000140859.16. [Q9BVG8-5]
DR Ensembl; ENST00000541240.5; ENSP00000442008.1; ENSG00000140859.16. [Q9BVG8-6]
DR Ensembl; ENST00000562903.5; ENSP00000456239.1; ENSG00000140859.16. [Q9BVG8-5]
DR GeneID; 3801; -.
DR KEGG; hsa:3801; -.
DR MANE-Select; ENST00000445690.7; ENSP00000401696.2; NM_001130100.2; NP_001123572.1. [Q9BVG8-2]
DR UCSC; uc002emm.4; human. [Q9BVG8-3]
DR CTD; 3801; -.
DR DisGeNET; 3801; -.
DR GeneCards; KIFC3; -.
DR HGNC; HGNC:6326; KIFC3.
DR HPA; ENSG00000140859; Low tissue specificity.
DR MIM; 604535; gene.
DR neXtProt; NX_Q9BVG8; -.
DR OpenTargets; ENSG00000140859; -.
DR PharmGKB; PA30112; -.
DR VEuPathDB; HostDB:ENSG00000140859; -.
DR eggNOG; KOG0239; Eukaryota.
DR GeneTree; ENSGT00940000154022; -.
DR HOGENOM; CLU_001485_12_6_1; -.
DR InParanoid; Q9BVG8; -.
DR OMA; RHDMQKC; -.
DR OrthoDB; 364605at2759; -.
DR TreeFam; TF105238; -.
DR PathwayCommons; Q9BVG8; -.
DR Reactome; R-HSA-390471; Association of TriC/CCT with target proteins during biosynthesis. [Q9BVG8-2]
DR SignaLink; Q9BVG8; -.
DR BioGRID-ORCS; 3801; 3 hits in 1073 CRISPR screens.
DR ChiTaRS; KIFC3; human.
DR EvolutionaryTrace; Q9BVG8; -.
DR GeneWiki; KIFC3; -.
DR GenomeRNAi; 3801; -.
DR Pharos; Q9BVG8; Tbio.
DR PRO; PR:Q9BVG8; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q9BVG8; protein.
DR Bgee; ENSG00000140859; Expressed in metanephros cortex and 142 other tissues.
DR ExpressionAtlas; Q9BVG8; baseline and differential.
DR Genevisible; Q9BVG8; HS.
DR GO; GO:0005813; C:centrosome; IDA:UniProtKB.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005871; C:kinesin complex; TAS:ProtInc.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0015630; C:microtubule cytoskeleton; IBA:GO_Central.
DR GO; GO:0005915; C:zonula adherens; IDA:UniProtKB.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0003777; F:microtubule motor activity; TAS:ProtInc.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0090136; P:epithelial cell-cell adhesion; IMP:UniProtKB.
DR GO; GO:0007030; P:Golgi organization; IEA:Ensembl.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR GO; GO:0007017; P:microtubule-based process; IBA:GO_Central.
DR GO; GO:0007601; P:visual perception; TAS:ProtInc.
DR GO; GO:0045218; P:zonula adherens maintenance; IMP:UniProtKB.
DR Gene3D; 3.40.850.10; -; 1.
DR InterPro; IPR027325; KIFC3-like.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR47972:SF5; PTHR47972:SF5; 1.
DR Pfam; PF00225; Kinesin; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; ATP-binding; Cell junction;
KW Coiled coil; Cytoplasm; Cytoplasmic vesicle; Cytoskeleton; Membrane;
KW Microtubule; Motor protein; Nucleotide-binding; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..833
FT /note="Kinesin-like protein KIFC3"
FT /id="PRO_0000125431"
FT DOMAIN 445..768
FT /note="Kinesin motor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00283"
FT REGION 19..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 786..833
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 102..362
FT /evidence="ECO:0000255"
FT COILED 395..432
FT /evidence="ECO:0000255"
FT COMPBIAS 30..46
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 798..819
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 528..535
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT MOD_RES 813
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 817
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 1..139
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_043724"
FT VAR_SEQ 1
FT /note="M -> MCASACKDTAAWCPEEAAEPQAM (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_057224"
FT VAR_SEQ 626..637
FT /note="FEFGHTNRTTEF -> WRREPLTTATLL (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_022361"
FT VAR_SEQ 638..833
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_022362"
FT VAR_SEQ 826..833
FT /note="GKSRPLPV -> A (in isoform 2, isoform 4 and isoform
FT 5)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334, ECO:0000303|PubMed:9782090,
FT ECO:0000303|Ref.2"
FT /id="VSP_021018"
FT VARIANT 391
FT /note="G -> V (in dbSNP:rs17854089)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_028114"
FT CONFLICT 150
FT /note="M -> L (in Ref. 6; AAC24153)"
FT /evidence="ECO:0000305"
FT CONFLICT 185
FT /note="S -> P (in Ref. 5; AAH34234)"
FT /evidence="ECO:0000305"
FT CONFLICT 281
FT /note="H -> S (in Ref. 5; AAH08014)"
FT /evidence="ECO:0000305"
FT CONFLICT 736
FT /note="D -> G (in Ref. 5; AAH34234)"
FT /evidence="ECO:0000305"
FT STRAND 446..452
FT /evidence="ECO:0007829|PDB:5WDE"
FT HELIX 457..459
FT /evidence="ECO:0007829|PDB:5WDE"
FT HELIX 463..465
FT /evidence="ECO:0007829|PDB:5WDE"
FT STRAND 469..471
FT /evidence="ECO:0007829|PDB:5WDE"
FT STRAND 478..483
FT /evidence="ECO:0007829|PDB:5WDE"
FT STRAND 486..491
FT /evidence="ECO:0007829|PDB:5WDE"
FT STRAND 493..496
FT /evidence="ECO:0007829|PDB:5WDE"
FT HELIX 502..506
FT /evidence="ECO:0007829|PDB:5WDE"
FT TURN 507..509
FT /evidence="ECO:0007829|PDB:5WDE"
FT HELIX 510..517
FT /evidence="ECO:0007829|PDB:5WDE"
FT STRAND 522..528
FT /evidence="ECO:0007829|PDB:5WDE"
FT HELIX 534..538
FT /evidence="ECO:0007829|PDB:5WDE"
FT STRAND 542..545
FT /evidence="ECO:0007829|PDB:5WDE"
FT HELIX 547..560
FT /evidence="ECO:0007829|PDB:5WDE"
FT STRAND 566..578
FT /evidence="ECO:0007829|PDB:5WDE"
FT STRAND 581..584
FT /evidence="ECO:0007829|PDB:5WDE"
FT HELIX 619..632
FT /evidence="ECO:0007829|PDB:5WDE"
FT HELIX 644..646
FT /evidence="ECO:0007829|PDB:5WDE"
FT STRAND 647..659
FT /evidence="ECO:0007829|PDB:5WDE"
FT TURN 660..662
FT /evidence="ECO:0007829|PDB:5WDE"
FT STRAND 665..674
FT /evidence="ECO:0007829|PDB:5WDE"
FT HELIX 689..712
FT /evidence="ECO:0007829|PDB:5WDE"
FT HELIX 720..722
FT /evidence="ECO:0007829|PDB:5WDE"
FT HELIX 724..728
FT /evidence="ECO:0007829|PDB:5WDE"
FT HELIX 730..732
FT /evidence="ECO:0007829|PDB:5WDE"
FT STRAND 738..745
FT /evidence="ECO:0007829|PDB:5WDE"
FT HELIX 749..751
FT /evidence="ECO:0007829|PDB:5WDE"
FT HELIX 752..765
FT /evidence="ECO:0007829|PDB:5WDE"
SQ SEQUENCE 833 AA; 92775 MW; 50983587270BDC2F CRC64;
MVPSRRTWNL GATPSLRGLW RVGRAPEPEP GMARPAPAPA SPAARPFPHT GPGRLRTGRG
KDTPVCGDED SSARSAARPA LAQCRALSVD WAGPGSPHGL YLTLQVEHLK EKLISQAQEV
SRLRSELGGT DLEKHRDLLM VENERLRQEM RRCEAELQEL RTKPAGPCPG CEHSQESAQL
RDKLSQLQLE MAESKGMLSE LNLEVQQKTD RLAEVELRLK DCLAEKAQEE ERLSRRLRDS
HETIASLRAQ SPPVKYVIKT VEVESSKTKQ ALSESQARNQ HLQEQVAMQR QVLKEMEQQL
QSSHQLTARL RAQIAMYESE LERAHGQMLE EMQSLEEDKN RAIEEAFARA QVEMKAVHEN
LAGVRTNLLT LQPALRTLTN DYNGLKRQVR GFPLLLQEAL RSVKAEIGQA IEEVNSNNQE
LLRKYRRELQ LRKKCHNELV RLKGNIRVIA RVRPVTKEDG EGPEATNAVT FDADDDSIIH
LLHKGKPVSF ELDKVFSPQA SQQDVFQEVQ ALVTSCIDGF NVCIFAYGQT GAGKTYTMEG
TAENPGINQR ALQLLFSEVQ EKASDWEYTI TVSAAEIYNE VLRDLLGKEP QEKLEIRLCP
DGSGQLYVPG LTEFQVQSVD DINKVFEFGH TNRTTEFTNL NEHSSRSHAL LIVTVRGVDC
STGLRTTGKL NLVDLAGSER VGKSGAEGSR LREAQHINKS LSALGDVIAA LRSRQGHVPF
RNSKLTYLLQ DSLSGDSKTL MVVQVSPVEK NTSETLYSLK FAERVRSVEL GPGLRRAELG
SWSSQEHLEW EPACQTPQPS ARAHSAPSSG TSSRPGSIRR KLQPSGKSRP LPV
