ID   KILR_ECOLI              Reviewed;          73 AA.
AC   P38393; P76058;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=Killing protein KilR;
DE   AltName: Full=FtsZ inhibitor protein KilR;
GN   Name=kilR; Synonyms=kil, ydaD; OrderedLocusNames=b1352, JW1347;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=K12;
RA   Clark A.J., Samra H.;
RL   Unpublished observations (AUG-1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=B;
RX   PubMed=7508908; DOI=10.1128/jb.176.4.1150-1156.1994;
RA   Faubladier M., Bouche J.-P.;
RT   "Division inhibition gene dicF of Escherichia coli reveals a widespread
RT   group of prophage sequences in bacterial genomes.";
RL   J. Bacteriol. 176:1150-1156(1994).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=9097039; DOI=10.1093/dnares/3.6.363;
RA   Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., Itoh T.,
RA   Kasai H., Kashimoto K., Kimura S., Kitakawa M., Kitagawa M., Makino K.,
RA   Miki T., Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S.,
RA   Nakamura Y., Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G.,
RA   Seki Y., Sivasundaram S., Tagami H., Takeda J., Takemoto K., Takeuchi Y.,
RA   Wada C., Yamamoto Y., Horiuchi T.;
RT   "A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT   the 28.0-40.1 min region on the linkage map.";
RL   DNA Res. 3:363-377(1996).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [6]
RP   FUNCTION IN INHIBITION OF CELL DIVISION.
RX   PubMed=8752325; DOI=10.1128/jb.178.17.5100-5104.1996;
RA   Conter A., Bouche J.-P., Dassain M.;
RT   "Identification of a new inhibitor of essential division gene ftsZ as the
RT   kil gene of defective prophage Rac.";
RL   J. Bacteriol. 178:5100-5104(1996).
CC   -!- FUNCTION: Causes inhibition of cell division. At high levels of
CC       expression, can also abolish the rod shape of the cells. Division
CC       inhibition by KilR can be relieved by overexpression of the cell
CC       division protein FtsZ. {ECO:0000269|PubMed:8752325}.
CC   -!- MISCELLANEOUS: This protein is encoded on Rac prophage.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA32250.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; Z23096; CAA80643.1; -; Genomic_DNA.
DR   EMBL; M96749; AAA32250.1; ALT_INIT; Genomic_DNA.
DR   EMBL; U00096; AAC74434.2; -; Genomic_DNA.
DR   EMBL; AP009048; BAA14955.1; -; Genomic_DNA.
DR   PIR; C64885; C64885.
DR   RefSeq; NP_415869.2; NC_000913.3.
DR   RefSeq; WP_000560225.1; NZ_CP047127.1.
DR   AlphaFoldDB; P38393; -.
DR   SMR; P38393; -.
DR   BioGRID; 4260165; 127.
DR   IntAct; P38393; 12.
DR   STRING; 511145.b1352; -.
DR   PaxDb; P38393; -.
DR   PRIDE; P38393; -.
DR   EnsemblBacteria; AAC74434; AAC74434; b1352.
DR   EnsemblBacteria; BAA14955; BAA14955; BAA14955.
DR   GeneID; 66674819; -.
DR   GeneID; 945921; -.
DR   KEGG; ecj:JW1347; -.
DR   KEGG; eco:b1352; -.
DR   PATRIC; fig|1411691.4.peg.924; -.
DR   EchoBASE; EB2075; -.
DR   eggNOG; ENOG5032TSE; Bacteria.
DR   HOGENOM; CLU_160564_0_0_6; -.
DR   OMA; MEIIMIA; -.
DR   BioCyc; EcoCyc:EG12155-MON; -.
DR   PRO; PR:P38393; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0051782; P:negative regulation of cell division; IMP:EcoliWiki.
DR   GO; GO:0046677; P:response to antibiotic; IMP:EcoCyc.
PE   1: Evidence at protein level;
KW   Cell cycle; Cell division; Reference proteome.
FT   CHAIN           1..73
FT                   /note="Killing protein KilR"
FT                   /id="PRO_0000084306"
FT   VARIANT         51
FT                   /note="F -> C (in strain: B)"
SQ   SEQUENCE   73 AA;  8434 MW;  26F03A1EEEAEE5FE CRC64;
     MIAHHFGTDE IPRQCVTPGD YVLHEGRTYI ASANNIKKRK LYIRNLTTKT FITDRMIKVF
     LGRDGLPVKA ESW