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KIME_BOVIN
ID   KIME_BOVIN              Reviewed;         396 AA.
AC   Q5E9T8;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Mevalonate kinase {ECO:0000305};
DE            Short=MK;
DE            EC=2.7.1.36 {ECO:0000250|UniProtKB:Q03426};
GN   Name=MVK {ECO:0000250|UniProtKB:Q03426};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Ascending colon;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the phosphorylation of mevalonate to mevalonate 5-
CC       phosphate, a key step in isoprenoid and cholesterol biosynthesis.
CC       {ECO:0000250|UniProtKB:Q03426}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H(+);
CC         Xref=Rhea:RHEA:17065, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:36464, ChEBI:CHEBI:58146, ChEBI:CHEBI:456216;
CC         EC=2.7.1.36; Evidence={ECO:0000250|UniProtKB:Q03426};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000250|UniProtKB:P17256};
CC   -!- ACTIVITY REGULATION: Farnesyl pyrophosphate and geranyl pyrophosphate
CC       inhibit mevalonate kinase activity by binding competitively at the ATP-
CC       binding sites. {ECO:0000250|UniProtKB:Q03426}.
CC   -!- PATHWAY: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis
CC       via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate:
CC       step 1/3.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:Q03426}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P17256}.
CC       Peroxisome {ECO:0000250|UniProtKB:P17256}.
CC   -!- SIMILARITY: Belongs to the GHMP kinase family. Mevalonate kinase
CC       subfamily. {ECO:0000305}.
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DR   EMBL; BT020832; AAX08849.1; -; mRNA.
DR   EMBL; BC104540; AAI04541.1; -; mRNA.
DR   RefSeq; NP_001015528.1; NM_001015528.1.
DR   AlphaFoldDB; Q5E9T8; -.
DR   SMR; Q5E9T8; -.
DR   STRING; 9913.ENSBTAP00000006828; -.
DR   PaxDb; Q5E9T8; -.
DR   PRIDE; Q5E9T8; -.
DR   Ensembl; ENSBTAT00000006828; ENSBTAP00000006828; ENSBTAG00000005183.
DR   GeneID; 505792; -.
DR   KEGG; bta:505792; -.
DR   CTD; 4598; -.
DR   VEuPathDB; HostDB:ENSBTAG00000005183; -.
DR   VGNC; VGNC:31768; MVK.
DR   eggNOG; KOG1511; Eukaryota.
DR   GeneTree; ENSGT00950000183187; -.
DR   InParanoid; Q5E9T8; -.
DR   OMA; NTVCTYG; -.
DR   OrthoDB; 1196330at2759; -.
DR   UniPathway; UPA00057; UER00098.
DR   Proteomes; UP000009136; Chromosome 17.
DR   Bgee; ENSBTAG00000005183; Expressed in diaphragm and 107 other tissues.
DR   ExpressionAtlas; Q5E9T8; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005777; C:peroxisome; ISS:UniProtKB.
DR   GO; GO:0005524; F:ATP binding; ISS:UniProtKB.
DR   GO; GO:0042802; F:identical protein binding; ISS:UniProtKB.
DR   GO; GO:0000287; F:magnesium ion binding; ISS:UniProtKB.
DR   GO; GO:0004496; F:mevalonate kinase activity; ISS:UniProtKB.
DR   GO; GO:0006695; P:cholesterol biosynthetic process; IBA:GO_Central.
DR   GO; GO:0019287; P:isopentenyl diphosphate biosynthetic process, mevalonate pathway; IBA:GO_Central.
DR   GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.70.890; -; 1.
DR   InterPro; IPR013750; GHMP_kinase_C_dom.
DR   InterPro; IPR036554; GHMP_kinase_C_sf.
DR   InterPro; IPR006204; GHMP_kinase_N_dom.
DR   InterPro; IPR006203; GHMP_knse_ATP-bd_CS.
DR   InterPro; IPR006205; Mev_gal_kin.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR43290; PTHR43290; 1.
DR   Pfam; PF08544; GHMP_kinases_C; 1.
DR   Pfam; PF00288; GHMP_kinases_N; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55060; SSF55060; 1.
DR   TIGRFAMs; TIGR00549; mevalon_kin; 1.
DR   PROSITE; PS00627; GHMP_KINASES_ATP; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Cholesterol biosynthesis; Cholesterol metabolism; Cytoplasm;
KW   Kinase; Lipid biosynthesis; Lipid metabolism; Magnesium; Metal-binding;
KW   Nucleotide-binding; Peroxisome; Reference proteome; Steroid biosynthesis;
KW   Steroid metabolism; Sterol biosynthesis; Sterol metabolism; Transferase.
FT   CHAIN           1..396
FT                   /note="Mevalonate kinase"
FT                   /id="PRO_0000282963"
FT   ACT_SITE        146
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250|UniProtKB:Q03426"
FT   ACT_SITE        204
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250|UniProtKB:Q03426"
FT   BINDING         13
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250|UniProtKB:P17256"
FT   BINDING         55
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250|UniProtKB:P17256"
FT   BINDING         135
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250|UniProtKB:P17256"
FT   BINDING         140..146
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250|UniProtKB:P17256"
FT   BINDING         146
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250|UniProtKB:P17256"
FT   BINDING         193
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250|UniProtKB:P17256"
SQ   SEQUENCE   396 AA;  42070 MW;  ADF4A6D40DA5C4FA CRC64;
     MLSEVLLVSA PGKVILHGEH AVVHGKVALA VALNLRTFLR LQPHSNGRVG LNLPNIGVRR
     AWDVASLQLL DTSFLGHGDS AALTAKHVEK LKEVAGFPKD CVDPEHLAVL AFLYLYLSIC
     QSQRALPSLD ITVWSELPTG AGLGSSAAYS VCLAAALLTA CEEIPNPLKD GEAAGRWTEE
     NLELINKWAF QGERVIHGNP SGVDNAVSTW GGALRYQQGK ISSLKRPPVL KILLINTKVP
     RSTKVLVANV RSRLLKFPEI VAPLLTSIDA ISLECERVLG EMAAAPTPEH YLTLEELIDM
     NQHHLNALGV GHASLDQLCQ VTTAHGLHSK LTGAGGGGCG ITLLRPDVER PAVEATKRAL
     SGCGFDCWET SVGAPGVSVH TAASLDASVQ QGLDSL
 
 
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