KIN16_CAEEL
ID KIN16_CAEEL Reviewed; 495 AA.
AC P34892;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 03-AUG-2022, entry version 162.
DE RecName: Full=Receptor-like tyrosine-protein kinase kin-16;
DE EC=2.7.10.1;
DE Flags: Precursor;
GN Name=kin-16; ORFNames=M176.7;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=8413302; DOI=10.1128/mcb.13.11.7133-7143.1993;
RA Morgan W.R., Greenwald I.;
RT "Two novel transmembrane protein tyrosine kinases expressed during
RT Caenorhabditis elegans hypodermal development.";
RL Mol. Cell. Biol. 13:7133-7143(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: May be specifically involved in cell-cell interactions
CC regulating cell fusions that generate the hypodermis during
CC postembryonic development. It has a role in the development of the HYP7
CC hypodermal syncytium.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000255|PROSITE-ProRule:PRU10028};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Hypodermal cells.
CC -!- DEVELOPMENTAL STAGE: Expressed during hypodermal development.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC kinase family. {ECO:0000255|PROSITE-ProRule:PRU00159}.
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DR EMBL; L03524; AAA28152.1; -; Genomic_DNA.
DR EMBL; Z78412; CAB01652.1; -; Genomic_DNA.
DR PIR; I44329; I44329.
DR RefSeq; NP_496017.1; NM_063616.3.
DR AlphaFoldDB; P34892; -.
DR SMR; P34892; -.
DR STRING; 6239.M176.7.1; -.
DR PaxDb; P34892; -.
DR EnsemblMetazoa; M176.7.1; M176.7.1; WBGene00002200.
DR GeneID; 174499; -.
DR KEGG; cel:CELE_M176.7; -.
DR UCSC; M176.7; c. elegans.
DR CTD; 174499; -.
DR WormBase; M176.7; CE12472; WBGene00002200; kin-16.
DR eggNOG; KOG0200; Eukaryota.
DR GeneTree; ENSGT00970000195899; -.
DR HOGENOM; CLU_000288_7_40_1; -.
DR InParanoid; P34892; -.
DR OMA; HCHVELY; -.
DR OrthoDB; 236292at2759; -.
DR PhylomeDB; P34892; -.
DR BRENDA; 2.7.10.1; 1045.
DR PRO; PR:P34892; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00002200; Expressed in larva and 1 other tissue.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0043235; C:receptor complex; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IBA:GO_Central.
DR GO; GO:0033674; P:positive regulation of kinase activity; IBA:GO_Central.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Cell membrane; Kinase; Membrane; Nucleotide-binding; Receptor;
KW Reference proteome; Signal; Transferase; Transmembrane;
KW Transmembrane helix; Tyrosine-protein kinase.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..495
FT /note="Receptor-like tyrosine-protein kinase kin-16"
FT /id="PRO_0000024438"
FT TOPO_DOM 23..60
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..81
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 82..495
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 140..455
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT ACT_SITE 321
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
FT ECO:0000255|PROSITE-ProRule:PRU10028"
FT BINDING 146..154
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT BINDING 179
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
SQ SEQUENCE 495 AA; 57507 MW; BDB6ADA8D90A33EF CRC64;
MQSFIFFVFL IYGFFPHCQS INDGNIKINL PNQQDVIYRY TRSERGDPAE KEGSVFKLRT
TVFFVVYGLL VLLAFIAFLV WRLRRSKTQE KRKNMALMNI YSDLRDTGDA MPEELKNRPL
NDKLDYLPYK KQYEIASENL ENKSILGSGN FGVVRKGILK MASPKNEEEK KMRLTVAVKS
AANCYDISQT SMLAAELRLM CSIGRFPNVL ALVGAVTSEL RKGRLLIVTE YIDCGDIRKY
LIDHRNVFQD HLIEDKTEPD SYLTPISAKR KNYVFKNTDE NSDYVIKESL DSLTTSDLLS
FGLQIANGMQ YLASIPMVHR DLALRNVLLK KNKTIRIADF GMARTHENKS YYIPQKTKDA
PVPVRWMSPE AFDTMKFTEK SDVWSFGICL YEIFTLGQLP YPDVPSERIY EYMHSGRRCP
QPQHCHVELY DLMKLCWHEK PELRPNFSNC VEYFIGHMKK SASKLLENVD EMLRVEAENQ
RKLEDWIRVE RSESV
