ID   KIPR_BACSU              Reviewed;         250 AA.
AC   P42968;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   16-JUN-2009, sequence version 4.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=HTH-type transcriptional regulator KipR;
DE   AltName: Full=Kip operon repressor protein;
GN   Name=kipR; Synonyms=ycsO; OrderedLocusNames=BSU04100;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=8574415; DOI=10.1099/13500872-141-12-3241;
RA   Akagawa E., Kurita K., Sugawara T., Nakamura K., Kasahara Y., Ogasawara N.,
RA   Yamane K.;
RT   "Determination of a 17,484 bp nucleotide sequence around the 39 degrees
RT   region of the Bacillus subtilis chromosome and similarity analysis of the
RT   products of putative ORFs.";
RL   Microbiology 141:3241-3245(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=8969502; DOI=10.1099/13500872-142-11-3047;
RA   Yamane K., Kumano M., Kurita K.;
RT   "The 25 degrees-36 degrees region of the Bacillus subtilis chromosome:
RT   determination of the sequence of a 146 kb segment and identification of 113
RT   genes.";
RL   Microbiology 142:3047-3056(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [4]
RP   SEQUENCE REVISION TO C-TERMINUS.
RX   PubMed=19383706; DOI=10.1099/mic.0.027839-0;
RA   Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A.,
RA   Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.;
RT   "From a consortium sequence to a unified sequence: the Bacillus subtilis
RT   168 reference genome a decade later.";
RL   Microbiology 155:1758-1775(2009).
RN   [5]
RP   FUNCTION.
RC   STRAIN=168 / JH642;
RX   PubMed=9334321; DOI=10.1101/gad.11.19.2569;
RA   Wang L., Grau R., Perego M., Hoch J.A.;
RT   "A novel histidine kinase inhibitor regulating development in Bacillus
RT   subtilis.";
RL   Genes Dev. 11:2569-2579(1997).
CC   -!- FUNCTION: Transcriptional repressor of the kip gene-containing operon.
CC       {ECO:0000269|PubMed:9334321}.
CC   -!- INDUCTION: Induced by glucose when readily available sources of
CC       nitrogen, such as ammonia or glutamine, are scarce.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA07362.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC       Sequence=BAA07362.1; Type=Frameshift; Evidence={ECO:0000305};
CC       Sequence=BAA09040.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; D38161; BAA07362.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; D50453; BAA09040.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; AL009126; CAB12217.2; -; Genomic_DNA.
DR   PIR; B69766; B69766.
DR   RefSeq; NP_388291.2; NC_000964.3.
DR   RefSeq; WP_003246517.1; NZ_JNCM01000031.1.
DR   RefSeq; WP_009966578.1; NZ_CM000487.1.
DR   AlphaFoldDB; P42968; -.
DR   SMR; P42968; -.
DR   STRING; 224308.BSU04100; -.
DR   PaxDb; P42968; -.
DR   PRIDE; P42968; -.
DR   EnsemblBacteria; CAB12217; CAB12217; BSU_04100.
DR   GeneID; 939999; -.
DR   KEGG; bsu:BSU04100; -.
DR   PATRIC; fig|224308.179.peg.436; -.
DR   eggNOG; COG1414; Bacteria.
DR   InParanoid; P42968; -.
DR   OMA; EPDRLHR; -.
DR   PhylomeDB; P42968; -.
DR   BioCyc; BSUB:BSU04100-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR014757; Tscrpt_reg_IclR_C.
DR   InterPro; IPR005471; Tscrpt_reg_IclR_N.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF09339; HTH_IclR; 1.
DR   Pfam; PF01614; IclR; 1.
DR   SMART; SM00346; HTH_ICLR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS51077; HTH_ICLR; 1.
DR   PROSITE; PS51078; ICLR_ED; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..250
FT                   /note="HTH-type transcriptional regulator KipR"
FT                   /id="PRO_0000201762"
FT   DOMAIN          5..65
FT                   /note="HTH iclR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00393"
FT   DOMAIN          80..249
FT                   /note="IclR-ED"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00394"
FT   DNA_BIND        26..45
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00393"
SQ   SEQUENCE   250 AA;  27746 MW;  13604974A4E39EA1 CRC64;
     MQNKNKTVVK SMALLNLFLH KPSLTLSELV SLTGMPKTSV HRMVSSLEEM GFLSRDASGA
     YSLGLVFLEF GQLVADRLDI RKIAKPVMEE LCREVDEAVQ LIMRDGNEAI YVEKIEGTQT
     VRLYTAIGRR SPLYAGACAR SILSFLPREE IEAYIKQTEL ISIGSGTITD PEKLLQEIDA
     SVQNGYTVSY SELENYTAAI GAPIFNHERQ VAAGISIAGF EARFTEDRLP YLTEKVKDAA
     LQISRKIGYT