KISHA_HUMAN
ID KISHA_HUMAN Reviewed; 72 AA.
AC Q8TBQ9; Q0P692;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Protein kish-A;
DE AltName: Full=Transmembrane protein 167;
DE AltName: Full=Transmembrane protein 167A;
DE Flags: Precursor;
GN Name=TMEM167A; Synonyms=TMEM167;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, Lung, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=19942856; DOI=10.1038/emboj.2009.350;
RA Wendler F., Gillingham A.K., Sinka R., Rosa-Ferreira C., Gordon D.E.,
RA Franch-Marro X., Peden A.A., Vincent J.P., Munro S.;
RT "A genome-wide RNA interference screen identifies two novel components of
RT the metazoan secretory pathway.";
RL EMBO J. 29:304-314(2010).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: Involved in the early part of the secretory pathway.
CC {ECO:0000269|PubMed:19942856}.
CC -!- INTERACTION:
CC Q8TBQ9; Q9Y5U9: IER3IP1; NbExp=5; IntAct=EBI-13383218, EBI-725665;
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000269|PubMed:19942856}; Single-pass type I membrane protein
CC {ECO:0000269|PubMed:19942856}.
CC -!- SIMILARITY: Belongs to the KISH family. {ECO:0000305}.
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DR EMBL; BC026285; AAH26285.1; -; mRNA.
DR EMBL; BC028585; AAH28585.1; -; mRNA.
DR EMBL; BC107575; AAI07576.1; -; mRNA.
DR CCDS; CCDS34198.1; -.
DR RefSeq; NP_777569.1; NM_174909.4.
DR AlphaFoldDB; Q8TBQ9; -.
DR BioGRID; 127490; 8.
DR IntAct; Q8TBQ9; 3.
DR MINT; Q8TBQ9; -.
DR STRING; 9606.ENSP00000424707; -.
DR GlyGen; Q8TBQ9; 2 sites, 1 O-linked glycan (1 site).
DR iPTMnet; Q8TBQ9; -.
DR PhosphoSitePlus; Q8TBQ9; -.
DR BioMuta; TMEM167A; -.
DR DMDM; 74730497; -.
DR EPD; Q8TBQ9; -.
DR jPOST; Q8TBQ9; -.
DR MassIVE; Q8TBQ9; -.
DR MaxQB; Q8TBQ9; -.
DR PaxDb; Q8TBQ9; -.
DR PeptideAtlas; Q8TBQ9; -.
DR PRIDE; Q8TBQ9; -.
DR ProteomicsDB; 74039; -.
DR TopDownProteomics; Q8TBQ9; -.
DR DNASU; 153339; -.
DR Ensembl; ENST00000502346.2; ENSP00000424707.1; ENSG00000174695.10.
DR GeneID; 153339; -.
DR KEGG; hsa:153339; -.
DR MANE-Select; ENST00000502346.2; ENSP00000424707.1; NM_174909.5; NP_777569.1.
DR UCSC; uc003khx.5; human.
DR CTD; 153339; -.
DR DisGeNET; 153339; -.
DR GeneCards; TMEM167A; -.
DR HGNC; HGNC:28330; TMEM167A.
DR HPA; ENSG00000174695; Low tissue specificity.
DR neXtProt; NX_Q8TBQ9; -.
DR OpenTargets; ENSG00000174695; -.
DR PharmGKB; PA162405909; -.
DR VEuPathDB; HostDB:ENSG00000174695; -.
DR eggNOG; KOG3808; Eukaryota.
DR GeneTree; ENSGT00940000155186; -.
DR HOGENOM; CLU_152663_1_1_1; -.
DR InParanoid; Q8TBQ9; -.
DR OMA; VGCFMMG; -.
DR OrthoDB; 1596132at2759; -.
DR PhylomeDB; Q8TBQ9; -.
DR TreeFam; TF300138; -.
DR PathwayCommons; Q8TBQ9; -.
DR SignaLink; Q8TBQ9; -.
DR BioGRID-ORCS; 153339; 157 hits in 1015 CRISPR screens.
DR ChiTaRS; TMEM167A; human.
DR GenomeRNAi; 153339; -.
DR Pharos; Q8TBQ9; Tdark.
DR PRO; PR:Q8TBQ9; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q8TBQ9; protein.
DR Bgee; ENSG00000174695; Expressed in adrenal tissue and 189 other tissues.
DR Genevisible; Q8TBQ9; HS.
DR GO; GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0045054; P:constitutive secretory pathway; IGI:UniProtKB.
DR GO; GO:0046907; P:intracellular transport; IBA:GO_Central.
DR GO; GO:0009306; P:protein secretion; IBA:GO_Central.
DR InterPro; IPR009653; Ksh1.
DR Pfam; PF06842; DUF1242; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Golgi apparatus; Membrane; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..72
FT /note="Protein kish-A"
FT /id="PRO_0000247768"
FT TOPO_DOM 27..53
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 54..71
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 72
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 35
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 72 AA; 8060 MW; 1A346F4BE4FD8C19 CRC64;
MSAIFNFQSL LTVILLLICT CAYIRSLAPS LLDRNKTGLL GIFWKCARIG ERKSPYVAVC
CIVMAFSILF IQ
