KISHA_MOUSE
ID KISHA_MOUSE Reviewed; 72 AA.
AC Q9CR64; Q8R3W3; Q9CZU1;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Protein kish-A;
DE AltName: Full=Transmembrane protein 167;
DE AltName: Full=Transmembrane protein 167A;
DE Flags: Precursor;
GN Name=Tmem167a; Synonyms=Tmem167;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J, and NOD;
RC TISSUE=Head, Kidney, Liver, Olfactory bulb, Pancreas, Testis, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Heart, Kidney, Liver, Lung, Pancreas, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Involved in the early part of the secretory pathway.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-
CC pass type I membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9CR64-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9CR64-2; Sequence=VSP_020044;
CC -!- SIMILARITY: Belongs to the KISH family. {ECO:0000305}.
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DR EMBL; AK002884; BAB22431.1; -; mRNA.
DR EMBL; AK007771; BAB25245.1; -; mRNA.
DR EMBL; AK007966; BAB25377.1; -; mRNA.
DR EMBL; AK012161; BAB28068.1; -; mRNA.
DR EMBL; AK016036; BAB30088.1; -; mRNA.
DR EMBL; AK016737; BAB30403.1; -; mRNA.
DR EMBL; AK021263; BAB32353.1; -; mRNA.
DR EMBL; AK031706; BAC27524.1; -; mRNA.
DR EMBL; AK032474; BAC27890.1; -; mRNA.
DR EMBL; AK088895; BAC40638.1; -; mRNA.
DR EMBL; AK132361; BAE21124.1; -; mRNA.
DR EMBL; AK160704; BAE35963.1; -; mRNA.
DR EMBL; AK161037; BAE36161.1; -; mRNA.
DR EMBL; BC024352; AAH24352.1; -; mRNA.
DR CCDS; CCDS36741.1; -. [Q9CR64-1]
DR RefSeq; NP_079611.2; NM_025335.3. [Q9CR64-1]
DR AlphaFoldDB; Q9CR64; -.
DR IntAct; Q9CR64; 1.
DR MINT; Q9CR64; -.
DR STRING; 10090.ENSMUSP00000125314; -.
DR GlyGen; Q9CR64; 1 site.
DR iPTMnet; Q9CR64; -.
DR PhosphoSitePlus; Q9CR64; -.
DR jPOST; Q9CR64; -.
DR MaxQB; Q9CR64; -.
DR PaxDb; Q9CR64; -.
DR PRIDE; Q9CR64; -.
DR DNASU; 66074; -.
DR Ensembl; ENSMUST00000012566; ENSMUSP00000012566; ENSMUSG00000012422. [Q9CR64-2]
DR Ensembl; ENSMUST00000161568; ENSMUSP00000125314; ENSMUSG00000012422. [Q9CR64-1]
DR GeneID; 66074; -.
DR KEGG; mmu:66074; -.
DR UCSC; uc007rjo.2; mouse. [Q9CR64-1]
DR CTD; 66074; -.
DR MGI; MGI:1913324; Tmem167.
DR VEuPathDB; HostDB:ENSMUSG00000012422; -.
DR eggNOG; KOG3808; Eukaryota.
DR GeneTree; ENSGT00940000155186; -.
DR HOGENOM; CLU_152663_1_1_1; -.
DR InParanoid; Q9CR64; -.
DR OMA; VGCFMMG; -.
DR OrthoDB; 1596132at2759; -.
DR PhylomeDB; Q9CR64; -.
DR TreeFam; TF300138; -.
DR BioGRID-ORCS; 66074; 10 hits in 67 CRISPR screens.
DR ChiTaRS; Tmem167; mouse.
DR PRO; PR:Q9CR64; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q9CR64; protein.
DR Bgee; ENSMUSG00000012422; Expressed in humerus cartilage element and 245 other tissues.
DR ExpressionAtlas; Q9CR64; baseline and differential.
DR Genevisible; Q9CR64; MM.
DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0045054; P:constitutive secretory pathway; ISO:MGI.
DR GO; GO:0046907; P:intracellular transport; IBA:GO_Central.
DR GO; GO:0009306; P:protein secretion; IBA:GO_Central.
DR InterPro; IPR009653; Ksh1.
DR Pfam; PF06842; DUF1242; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Glycoprotein; Golgi apparatus; Membrane;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..72
FT /note="Protein kish-A"
FT /id="PRO_0000247769"
FT TOPO_DOM 27..53
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 54..71
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 72
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 35
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 51..72
FT /note="ERKSPYVAICCIVMAFSILFIQ -> SVYWQDTFTS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_020044"
FT CONFLICT 20
FT /note="T -> I (in Ref. 1; BAB28068)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 72 AA; 8074 MW; 1A307B1AA5E52F19 CRC64;
MSAIFNFQSL LTVILLLICT CAYIRSLAPS ILDRNKTGLL GIFWKCARIG ERKSPYVAIC
CIVMAFSILF IQ
