KISHB_HUMAN
ID KISHB_HUMAN Reviewed; 74 AA.
AC Q9NRX6; B2RUU9;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Protein kish-B;
DE AltName: Full=Transmembrane protein 167B;
DE Flags: Precursor;
GN Name=TMEM167B; Synonyms=C1orf119; ORFNames=AD-020;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Adrenal gland;
RX PubMed=10931946; DOI=10.1073/pnas.160270997;
RA Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X.,
RA Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W.,
RA Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M., Zhou J., Xu S.-H., Gu J.,
RA Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z.,
RA Chen M.-D., Chen J.-L.;
RT "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis
RT and full-length cDNA cloning.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, Skin, Testis, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=19942856; DOI=10.1038/emboj.2009.350;
RA Wendler F., Gillingham A.K., Sinka R., Rosa-Ferreira C., Gordon D.E.,
RA Franch-Marro X., Peden A.A., Vincent J.P., Munro S.;
RT "A genome-wide RNA interference screen identifies two novel components of
RT the metazoan secretory pathway.";
RL EMBO J. 29:304-314(2010).
CC -!- FUNCTION: Involved in the early part of the secretory pathway.
CC {ECO:0000269|PubMed:19942856}.
CC -!- INTERACTION:
CC Q9NRX6; O00590: ACKR2; NbExp=3; IntAct=EBI-17684533, EBI-13379418;
CC Q9NRX6; Q9NRZ7: AGPAT3; NbExp=3; IntAct=EBI-17684533, EBI-2803601;
CC Q9NRX6; O95236-2: APOL3; NbExp=3; IntAct=EBI-17684533, EBI-11976321;
CC Q9NRX6; Q96PS8: AQP10; NbExp=3; IntAct=EBI-17684533, EBI-12820279;
CC Q9NRX6; Q13520: AQP6; NbExp=3; IntAct=EBI-17684533, EBI-13059134;
CC Q9NRX6; Q12797-6: ASPH; NbExp=3; IntAct=EBI-17684533, EBI-12092171;
CC Q9NRX6; Q08708: CD300C; NbExp=3; IntAct=EBI-17684533, EBI-3915344;
CC Q9NRX6; Q08722-3: CD47; NbExp=3; IntAct=EBI-17684533, EBI-17263290;
CC Q9NRX6; Q4LDR2: CTXN3; NbExp=3; IntAct=EBI-17684533, EBI-12019274;
CC Q9NRX6; Q15125: EBP; NbExp=3; IntAct=EBI-17684533, EBI-3915253;
CC Q9NRX6; Q8NBQ5: HSD17B11; NbExp=3; IntAct=EBI-17684533, EBI-1052304;
CC Q9NRX6; Q7Z5P4: HSD17B13; NbExp=3; IntAct=EBI-17684533, EBI-18053395;
CC Q9NRX6; Q6P1Q0: LETMD1; NbExp=3; IntAct=EBI-17684533, EBI-1549822;
CC Q9NRX6; P48449: LSS; NbExp=3; IntAct=EBI-17684533, EBI-3930711;
CC Q9NRX6; Q5SR56: MFSD14B; NbExp=3; IntAct=EBI-17684533, EBI-373355;
CC Q9NRX6; Q99735: MGST2; NbExp=3; IntAct=EBI-17684533, EBI-11324706;
CC Q9NRX6; Q8N912: NRAC; NbExp=3; IntAct=EBI-17684533, EBI-12051377;
CC Q9NRX6; Q9Y342: PLLP; NbExp=3; IntAct=EBI-17684533, EBI-3919291;
CC Q9NRX6; Q9H6H4: REEP4; NbExp=3; IntAct=EBI-17684533, EBI-7545592;
CC Q9NRX6; Q9NTJ5: SACM1L; NbExp=3; IntAct=EBI-17684533, EBI-3917235;
CC Q9NRX6; O75396: SEC22B; NbExp=3; IntAct=EBI-17684533, EBI-1058865;
CC Q9NRX6; Q8N130: SLC34A3; NbExp=3; IntAct=EBI-17684533, EBI-17769653;
CC Q9NRX6; O60906: SMPD2; NbExp=3; IntAct=EBI-17684533, EBI-12828299;
CC Q9NRX6; Q86Y82: STX12; NbExp=3; IntAct=EBI-17684533, EBI-2691717;
CC Q9NRX6; P61266: STX1B; NbExp=3; IntAct=EBI-17684533, EBI-9071709;
CC Q9NRX6; P59542: TAS2R19; NbExp=3; IntAct=EBI-17684533, EBI-12847034;
CC Q9NRX6; Q96DZ7: TM4SF19; NbExp=3; IntAct=EBI-17684533, EBI-6448756;
CC Q9NRX6; Q9NV29: TMEM100; NbExp=3; IntAct=EBI-17684533, EBI-8644968;
CC Q9NRX6; Q6UX40: TMEM107; NbExp=3; IntAct=EBI-17684533, EBI-12845616;
CC Q9NRX6; Q53HI1: UNC50; NbExp=3; IntAct=EBI-17684533, EBI-7601760;
CC Q9NRX6; Q8IVQ6: ZDHHC21; NbExp=3; IntAct=EBI-17684533, EBI-2849773;
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000269|PubMed:19942856}; Single-pass type I membrane protein
CC {ECO:0000269|PubMed:19942856}.
CC -!- SIMILARITY: Belongs to the KISH family. {ECO:0000305}.
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DR EMBL; AF164793; AAF80757.1; -; mRNA.
DR EMBL; AK291293; BAF83982.1; -; mRNA.
DR EMBL; AL356488; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471122; EAW56356.1; -; Genomic_DNA.
DR EMBL; BC008739; AAH08739.1; -; mRNA.
DR EMBL; BC065186; AAH65186.1; -; mRNA.
DR EMBL; BC066918; AAH66918.1; -; mRNA.
DR EMBL; BC067116; AAH67116.1; -; mRNA.
DR EMBL; BC146873; AAI46874.1; -; mRNA.
DR EMBL; BC146879; AAI46880.1; -; mRNA.
DR EMBL; BC171849; AAI71849.1; -; mRNA.
DR CCDS; CCDS30789.1; -.
DR RefSeq; NP_001309177.1; NM_001322248.1.
DR RefSeq; NP_064526.1; NM_020141.3.
DR AlphaFoldDB; Q9NRX6; -.
DR BioGRID; 121230; 41.
DR IntAct; Q9NRX6; 31.
DR STRING; 9606.ENSP00000342148; -.
DR iPTMnet; Q9NRX6; -.
DR PhosphoSitePlus; Q9NRX6; -.
DR BioMuta; TMEM167B; -.
DR DMDM; 74752932; -.
DR jPOST; Q9NRX6; -.
DR MassIVE; Q9NRX6; -.
DR PaxDb; Q9NRX6; -.
DR PeptideAtlas; Q9NRX6; -.
DR PRIDE; Q9NRX6; -.
DR ProteomicsDB; 82438; -.
DR DNASU; 56900; -.
DR Ensembl; ENST00000338272.9; ENSP00000342148.7; ENSG00000215717.7.
DR GeneID; 56900; -.
DR KEGG; hsa:56900; -.
DR MANE-Select; ENST00000338272.9; ENSP00000342148.7; NM_020141.4; NP_064526.1.
DR UCSC; uc001dwn.4; human.
DR CTD; 56900; -.
DR GeneCards; TMEM167B; -.
DR HGNC; HGNC:30187; TMEM167B.
DR HPA; ENSG00000215717; Low tissue specificity.
DR neXtProt; NX_Q9NRX6; -.
DR OpenTargets; ENSG00000215717; -.
DR PharmGKB; PA162405910; -.
DR VEuPathDB; HostDB:ENSG00000215717; -.
DR eggNOG; KOG3808; Eukaryota.
DR GeneTree; ENSGT00940000162196; -.
DR HOGENOM; CLU_152663_1_2_1; -.
DR InParanoid; Q9NRX6; -.
DR OMA; CTCAYMS; -.
DR OrthoDB; 1495548at2759; -.
DR PhylomeDB; Q9NRX6; -.
DR TreeFam; TF300138; -.
DR PathwayCommons; Q9NRX6; -.
DR SignaLink; Q9NRX6; -.
DR BioGRID-ORCS; 56900; 11 hits in 1080 CRISPR screens.
DR ChiTaRS; TMEM167B; human.
DR GenomeRNAi; 56900; -.
DR Pharos; Q9NRX6; Tdark.
DR PRO; PR:Q9NRX6; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q9NRX6; protein.
DR Bgee; ENSG00000215717; Expressed in upper arm skin and 194 other tissues.
DR ExpressionAtlas; Q9NRX6; baseline and differential.
DR Genevisible; Q9NRX6; HS.
DR GO; GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0045054; P:constitutive secretory pathway; IGI:UniProtKB.
DR InterPro; IPR042863; Kish-B.
DR InterPro; IPR009653; Ksh1.
DR PANTHER; PTHR46815; PTHR46815; 1.
DR Pfam; PF06842; DUF1242; 1.
PE 1: Evidence at protein level;
KW Golgi apparatus; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..74
FT /note="Protein kish-B"
FT /id="PRO_0000265081"
FT TOPO_DOM 23..52
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 74
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 74 AA; 8294 MW; 3ADBFA3B0DF48C29 CRC64;
MTNVYSLDGI LVFGLLFVCT CAYFKKVPRL KTWLLSEKKG VWGVFYKAAV IGTRLHAAVA
IACVVMAFYV LFIK
