KISHB_MOUSE
ID KISHB_MOUSE Reviewed; 74 AA.
AC Q80X45; Q3U299; Q8BL15; Q9D863;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Protein kish-B;
DE AltName: Full=Transmembrane protein 167B;
DE Flags: Precursor;
GN Name=Tmem167b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Adipose tissue, and Small intestine;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and Czech II; TISSUE=Brain, and Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Involved in the early part of the secretory pathway.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-
CC pass type I membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the KISH family. {ECO:0000305}.
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DR EMBL; AK008415; BAB25656.1; -; mRNA.
DR EMBL; AK046697; BAC32839.1; -; mRNA.
DR EMBL; AK155399; BAE33243.1; -; mRNA.
DR EMBL; BC050932; AAH50932.1; -; mRNA.
DR EMBL; BC055449; AAH55449.1; -; mRNA.
DR CCDS; CCDS38601.1; -.
DR RefSeq; NP_080474.2; NM_026198.2.
DR AlphaFoldDB; Q80X45; -.
DR STRING; 10090.ENSMUSP00000088035; -.
DR PhosphoSitePlus; Q80X45; -.
DR PaxDb; Q80X45; -.
DR PRIDE; Q80X45; -.
DR ProteomicsDB; 264997; -.
DR Ensembl; ENSMUST00000090546; ENSMUSP00000088035; ENSMUSG00000068732.
DR GeneID; 67495; -.
DR KEGG; mmu:67495; -.
DR UCSC; uc008qzg.2; mouse.
DR CTD; 56900; -.
DR MGI; MGI:1914745; Tmem167b.
DR VEuPathDB; HostDB:ENSMUSG00000068732; -.
DR eggNOG; KOG3808; Eukaryota.
DR GeneTree; ENSGT00690000103864; -.
DR HOGENOM; CLU_152663_1_2_1; -.
DR InParanoid; Q80X45; -.
DR OMA; CTCAYMS; -.
DR OrthoDB; 1596132at2759; -.
DR TreeFam; TF300138; -.
DR BioGRID-ORCS; 67495; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Tmem167b; mouse.
DR PRO; PR:Q80X45; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q80X45; protein.
DR Bgee; ENSMUSG00000068732; Expressed in lumbar dorsal root ganglion and 211 other tissues.
DR ExpressionAtlas; Q80X45; baseline and differential.
DR Genevisible; Q80X45; MM.
DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0045054; P:constitutive secretory pathway; ISO:MGI.
DR InterPro; IPR042863; Kish-B.
DR InterPro; IPR009653; Ksh1.
DR PANTHER; PTHR46815; PTHR46815; 1.
DR Pfam; PF06842; DUF1242; 1.
PE 3: Inferred from homology;
KW Golgi apparatus; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..74
FT /note="Protein kish-B"
FT /id="PRO_0000265082"
FT TOPO_DOM 23..52
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 74
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CONFLICT 62
FT /note="A -> T (in Ref. 1; BAC32839)"
FT /evidence="ECO:0000305"
FT CONFLICT 73
FT /note="I -> N (in Ref. 1; BAB25656)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 74 AA; 8308 MW; 3ADBE2980DF48C29 CRC64;
MTNVYSLDGI LVFGLLFVCT CAYFKKVPRL KTWLLSEKKG VWGVFYKAAV IGTRLHAAVA
IACIVMAFYV LFIK
