ID   KISS1_MACMU             Reviewed;          88 AA.
AC   Q5PXH1;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Metastasis-suppressor KiSS-1;
DE   AltName: Full=Kisspeptin-1;
DE   Contains:
DE     RecName: Full=Metastin;
DE   Contains:
DE     RecName: Full=Kisspeptin-10;
DE   Flags: Precursor; Fragment;
GN   Name=KISS1;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC   TISSUE=Hypothalamus;
RX   PubMed=15684075; DOI=10.1073/pnas.0409822102;
RA   Shahab M., Mastronardi C., Seminara S.B., Crowley W.F., Ojeda S.R.,
RA   Plant T.M.;
RT   "Increased hypothalamic GPR54 signaling: a potential mechanism for
RT   initiation of puberty in primates.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:2129-2134(2005).
CC   -!- FUNCTION: Metastasis suppressor protein. May regulate events downstream
CC       of cell-matrix adhesion, perhaps involving cytoskeletal reorganization.
CC       Generates a C-terminally amidated peptide, metastin which functions as
CC       the endogenous ligand of the G-protein coupled receptor GPR54. The
CC       receptor is essential for normal gonadotropin-released hormone
CC       physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a
CC       pivotal factor in central regulation of the gonadotropic axis at
CC       puberty and in adulthood. {ECO:0000269|PubMed:15684075}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: In the hypothalamus, expression increases with
CC       puberty in both male and female monkeys. Robust expression in the
CC       region of the arcuate nucleus (ARC). {ECO:0000269|PubMed:15684075}.
CC   -!- SIMILARITY: Belongs to the KISS1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY823262; AAV70983.1; -; mRNA.
DR   AlphaFoldDB; Q5PXH1; -.
DR   STRING; 9544.ENSMMUP00000038127; -.
DR   eggNOG; ENOG502SFM2; Eukaryota.
DR   HOGENOM; CLU_119112_0_0_1; -.
DR   InParanoid; Q5PXH1; -.
DR   Proteomes; UP000006718; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR   GO; GO:0031773; F:kisspeptin receptor binding; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR   InterPro; IPR020207; Metastasis-suppressor_KiSS-1.
DR   PANTHER; PTHR16955; PTHR16955; 1.
DR   Pfam; PF15152; Kisspeptin; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Phosphoprotein; Reference proteome;
KW   Secreted.
FT   CHAIN           <1..>88
FT                   /note="Metastasis-suppressor KiSS-1"
FT                   /id="PRO_0000021549"
FT   PEPTIDE         42..>88
FT                   /note="Metastin"
FT                   /id="PRO_0000021550"
FT   PEPTIDE         86..>88
FT                   /note="Kisspeptin-10"
FT                   /id="PRO_0000021551"
FT   REGION          1..88
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..18
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        39..68
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         86
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q15726"
FT   NON_TER         1
FT   NON_TER         88
SQ   SEQUENCE   88 AA;  9514 MW;  49B418F841E56909 CRC64;
     SVENSRPTGQ QLESLDLSAP WEQSLPCTER KPSATARLSR RGASLSSPAE SSGSPQRRGL
     SAPSSRQIPA PQGAVLVQRE KDLPNYNW