ID   ARAC_CITFR              Reviewed;         281 AA.
AC   P11765;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1989, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Arabinose operon regulatory protein;
GN   Name=araC {ECO:0000303|PubMed:2965663};
OS   Citrobacter freundii.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Citrobacter; Citrobacter freundii complex.
OX   NCBI_TaxID=546;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2965663; DOI=10.1016/0378-1119(87)90188-0;
RA   Burke K.A., Wilcox G.;
RT   "The araC gene of Citrobacter freundii.";
RL   Gene 61:243-252(1987).
CC   -!- FUNCTION: Transcription factor that regulates the expression of several
CC       genes involved in the transport and metabolism of L-arabinose.
CC       {ECO:0000250|UniProtKB:P0A9E0}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:P0A9E0}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P0A9E0}.
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DR   EMBL; M18833; AAA23092.1; -; Genomic_DNA.
DR   PIR; A29633; A29633.
DR   RefSeq; WP_003018834.1; NZ_VTEC01000069.1.
DR   AlphaFoldDB; P11765; -.
DR   BMRB; P11765; -.
DR   SMR; P11765; -.
DR   STRING; 1333848.CFNIH1_10030; -.
DR   GeneID; 66271412; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0019568; P:arabinose catabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR003313; AraC-bd.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR037923; HTH-like.
DR   InterPro; IPR018060; HTH_AraC.
DR   InterPro; IPR018062; HTH_AraC-typ_CS.
DR   InterPro; IPR020449; Tscrpt_reg_HTH_AraC-type.
DR   Pfam; PF02311; AraC_binding; 1.
DR   Pfam; PF12833; HTH_18; 1.
DR   PRINTS; PR00032; HTHARAC.
DR   SMART; SM00342; HTH_ARAC; 1.
DR   SUPFAM; SSF46689; SSF46689; 2.
DR   SUPFAM; SSF51215; SSF51215; 1.
DR   PROSITE; PS00041; HTH_ARAC_FAMILY_1; 1.
DR   PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE   3: Inferred from homology;
KW   Activator; Arabinose catabolism; Carbohydrate metabolism; Cytoplasm;
KW   DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..281
FT                   /note="Arabinose operon regulatory protein"
FT                   /id="PRO_0000194498"
FT   DOMAIN          180..279
FT                   /note="HTH araC/xylS-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        198..219
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        246..269
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   BINDING         8
FT                   /ligand="alpha-L-arabinopyanose"
FT                   /ligand_id="ChEBI:CHEBI:46987"
FT                   /evidence="ECO:0000250|UniProtKB:P0A9E0"
FT   BINDING         24
FT                   /ligand="alpha-L-arabinopyanose"
FT                   /ligand_id="ChEBI:CHEBI:46987"
FT                   /evidence="ECO:0000250|UniProtKB:P0A9E0"
FT   BINDING         38
FT                   /ligand="alpha-L-arabinopyanose"
FT                   /ligand_id="ChEBI:CHEBI:46987"
FT                   /evidence="ECO:0000250|UniProtKB:P0A9E0"
FT   BINDING         82
FT                   /ligand="alpha-L-arabinopyanose"
FT                   /ligand_id="ChEBI:CHEBI:46987"
FT                   /evidence="ECO:0000250|UniProtKB:P0A9E0"
FT   BINDING         93
FT                   /ligand="alpha-L-arabinopyanose"
FT                   /ligand_id="ChEBI:CHEBI:46987"
FT                   /evidence="ECO:0000250|UniProtKB:P0A9E0"
SQ   SEQUENCE   281 AA;  32122 MW;  5811A735E31AD7C8 CRC64;
     MAETQNDPLL PGYSFNAHLV AGLTPIEANG YLDFFIDRPL GMKGYILNLT IRGEGVINNQ
     GKQFVCRPGD ILLFPPGEIH HYGRHPDASE WYHQWVYFRP RAYWQEWLTW PAIFAQTGFF
     RPDEAHQPHF NELFGQIINA GQGEGRYSEL LAINLLEQLL LRRMEAINES LHPPMDNRVR
     DACQYISDHL ADSNFDIASV AQHVCLSPSR LSHLFRQQLG ISVLSWREDQ RISQAKLLLS
     TTRMPIATVG RNVGFDDQLY FSRVFKKCTG ASPSEFRAGC E