ID   ARAC_DICCH              Reviewed;         310 AA.
AC   P07642;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1988, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Arabinose operon regulatory protein;
GN   Name=araC {ECO:0000303|PubMed:3902795};
OS   Dickeya chrysanthemi (Pectobacterium chrysanthemi) (Erwinia chrysanthemi).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Pectobacteriaceae; Dickeya.
OX   NCBI_TaxID=556;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3902795; DOI=10.1128/jb.164.2.717-722.1985;
RA   Lei S.-P., Lin H.-C., Heffernan L., Wilcox G.;
RT   "araB gene and nucleotide sequence of the araC gene of Erwinia
RT   carotovora.";
RL   J. Bacteriol. 164:717-722(1985).
CC   -!- FUNCTION: Transcription factor that regulates the expression of several
CC       genes involved in the transport and metabolism of L-arabinose.
CC       {ECO:0000250|UniProtKB:P0A9E0}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:P0A9E0}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P0A9E0}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M11981; AAA24811.1; -; Genomic_DNA.
DR   AlphaFoldDB; P07642; -.
DR   SMR; P07642; -.
DR   PRIDE; P07642; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0019568; P:arabinose catabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR003313; AraC-bd.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR037923; HTH-like.
DR   InterPro; IPR018060; HTH_AraC.
DR   InterPro; IPR018062; HTH_AraC-typ_CS.
DR   InterPro; IPR020449; Tscrpt_reg_HTH_AraC-type.
DR   Pfam; PF02311; AraC_binding; 1.
DR   Pfam; PF12833; HTH_18; 1.
DR   PRINTS; PR00032; HTHARAC.
DR   SMART; SM00342; HTH_ARAC; 1.
DR   SUPFAM; SSF46689; SSF46689; 2.
DR   SUPFAM; SSF51215; SSF51215; 1.
DR   PROSITE; PS00041; HTH_ARAC_FAMILY_1; 1.
DR   PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE   3: Inferred from homology;
KW   Activator; Arabinose catabolism; Carbohydrate metabolism; Cytoplasm;
KW   DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..310
FT                   /note="Arabinose operon regulatory protein"
FT                   /id="PRO_0000194501"
FT   DOMAIN          186..284
FT                   /note="HTH araC/xylS-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        203..224
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        251..274
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   BINDING         13
FT                   /ligand="alpha-L-arabinopyanose"
FT                   /ligand_id="ChEBI:CHEBI:46987"
FT                   /evidence="ECO:0000250|UniProtKB:P0A9E0"
FT   BINDING         29
FT                   /ligand="alpha-L-arabinopyanose"
FT                   /ligand_id="ChEBI:CHEBI:46987"
FT                   /evidence="ECO:0000250|UniProtKB:P0A9E0"
FT   BINDING         43
FT                   /ligand="alpha-L-arabinopyanose"
FT                   /ligand_id="ChEBI:CHEBI:46987"
FT                   /evidence="ECO:0000250|UniProtKB:P0A9E0"
FT   BINDING         87
FT                   /ligand="alpha-L-arabinopyanose"
FT                   /ligand_id="ChEBI:CHEBI:46987"
FT                   /evidence="ECO:0000250|UniProtKB:P0A9E0"
FT   BINDING         98
FT                   /ligand="alpha-L-arabinopyanose"
FT                   /ligand_id="ChEBI:CHEBI:46987"
FT                   /evidence="ECO:0000250|UniProtKB:P0A9E0"
SQ   SEQUENCE   310 AA;  35854 MW;  B718C9F4B264B0AF CRC64;
     MYHRMAHESQ PNPLLPGYSF NAYLVAGLTP ILAEGPLDFF IDRPDGMKGY IINLTMKGQG
     QIFDGDETFF CNPGDLLLFP PKSTHFYGRS PSSDCWYHRW VYFRPRAYWA DWLEWHTKSS
     GIGRMSLPNN QLLLEFDRLF ANIEQTQRSG RRFSEELGMN LLERLLLRAM EEDPQSPQKI
     MDPRVIEACQ FITSNLAGEL RIDEVARHVC LSPSRLAHLF REQVGINILR WREDQRVIRA
     KLLLQTTQES IANIGRVVGY DDQLYFSRVF RKRVGVSPSD FRRRSSEINY PAAKTLPVAW
     GEQIPHAVSS