ID   ARAC_SALTY              Reviewed;         281 AA.
AC   P03022;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   03-AUG-2022, entry version 149.
DE   RecName: Full=Arabinose operon regulatory protein;
GN   Name=araC {ECO:0000303|PubMed:6751938}; OrderedLocusNames=STM0104;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=LT2;
RX   PubMed=6751938; DOI=10.1016/0378-1119(82)90113-5;
RA   Clarke P., Lin H.-C., Wilcox G.;
RT   "The nucleotide sequence of the araC regulatory gene in Salmonella
RT   typhimurium LT2.";
RL   Gene 18:157-163(1982).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
RN   [3]
RP   MUTAGENESIS.
RC   STRAIN=LT2;
RX   PubMed=1644312; DOI=10.1016/0378-1119(92)90486-9;
RA   Clarke P., Lee J.-H., Burke K., Wilcox G.;
RT   "Mutations in the araC gene of Salmonella typhimurium LT2 which affect both
RT   activator and auto-regulatory functions of the AraC protein.";
RL   Gene 117:31-37(1992).
CC   -!- FUNCTION: Transcription factor that regulates the expression of several
CC       genes involved in the transport and metabolism of L-arabinose.
CC       {ECO:0000250|UniProtKB:P0A9E0}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:P0A9E0}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P0A9E0}.
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DR   EMBL; J01797; AAA27026.1; -; Genomic_DNA.
DR   EMBL; AE006468; AAL19068.1; -; Genomic_DNA.
DR   PIR; A03555; RGEBAT.
DR   RefSeq; NP_459109.1; NC_003197.2.
DR   RefSeq; WP_000852387.1; NC_003197.2.
DR   AlphaFoldDB; P03022; -.
DR   BMRB; P03022; -.
DR   SMR; P03022; -.
DR   STRING; 99287.STM0104; -.
DR   PaxDb; P03022; -.
DR   EnsemblBacteria; AAL19068; AAL19068; STM0104.
DR   GeneID; 1251622; -.
DR   KEGG; stm:STM0104; -.
DR   PATRIC; fig|99287.12.peg.107; -.
DR   HOGENOM; CLU_000445_88_6_6; -.
DR   OMA; GFEDQLY; -.
DR   PhylomeDB; P03022; -.
DR   BioCyc; SENT99287:STM0104-MON; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0019568; P:arabinose catabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR003313; AraC-bd.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR037923; HTH-like.
DR   InterPro; IPR018060; HTH_AraC.
DR   InterPro; IPR018062; HTH_AraC-typ_CS.
DR   InterPro; IPR020449; Tscrpt_reg_HTH_AraC-type.
DR   Pfam; PF02311; AraC_binding; 1.
DR   Pfam; PF12833; HTH_18; 1.
DR   PRINTS; PR00032; HTHARAC.
DR   SMART; SM00342; HTH_ARAC; 1.
DR   SUPFAM; SSF46689; SSF46689; 2.
DR   SUPFAM; SSF51215; SSF51215; 1.
DR   PROSITE; PS00041; HTH_ARAC_FAMILY_1; 1.
DR   PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE   3: Inferred from homology;
KW   Activator; Arabinose catabolism; Carbohydrate metabolism; Cytoplasm;
KW   DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..281
FT                   /note="Arabinose operon regulatory protein"
FT                   /id="PRO_0000194502"
FT   DOMAIN          180..279
FT                   /note="HTH araC/xylS-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        198..219
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        246..269
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   BINDING         8
FT                   /ligand="alpha-L-arabinopyanose"
FT                   /ligand_id="ChEBI:CHEBI:46987"
FT                   /evidence="ECO:0000250|UniProtKB:P0A9E0"
FT   BINDING         24
FT                   /ligand="alpha-L-arabinopyanose"
FT                   /ligand_id="ChEBI:CHEBI:46987"
FT                   /evidence="ECO:0000250|UniProtKB:P0A9E0"
FT   BINDING         38
FT                   /ligand="alpha-L-arabinopyanose"
FT                   /ligand_id="ChEBI:CHEBI:46987"
FT                   /evidence="ECO:0000250|UniProtKB:P0A9E0"
FT   BINDING         82
FT                   /ligand="alpha-L-arabinopyanose"
FT                   /ligand_id="ChEBI:CHEBI:46987"
FT                   /evidence="ECO:0000250|UniProtKB:P0A9E0"
FT   BINDING         93
FT                   /ligand="alpha-L-arabinopyanose"
FT                   /ligand_id="ChEBI:CHEBI:46987"
FT                   /evidence="ECO:0000250|UniProtKB:P0A9E0"
SQ   SEQUENCE   281 AA;  32070 MW;  1416DF04FB9F1E33 CRC64;
     MAETQNDPLL PGYSFNAHLV AGLTPIEANG YLDFFIDRPL GMKGYILNLT IRGEGVINNN
     GEQFVCRPGD ILLFPPGEIH HYGRHPDASE WYHQWVYFRP RAYWQEWLTW PTIFAQTGFF
     RPDEARQPHF SELFGQIISA GQGEGRYSEL LAINLLEQLL LRRMAVINES LHPPMDSRVR
     DACQYISDHL ADSHFDIASV AQHVCLSPSR LSHLFRQQLG ISVLSWREDQ RISQAKLLLS
     TTRMPIATVG RNVGFDDQLY FSRVFKKCTG ASPSEFRAGC E