ID   KIT_FSVHZ               Reviewed;         370 AA.
AC   P04048;
DT   01-NOV-1986, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1986, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Tyrosine-protein kinase transforming protein kit;
DE            EC=2.7.10.1;
GN   Name=V-KIT;
OS   Feline sarcoma virus (strain Hardy-Zuckerman 4).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Gammaretrovirus.
OX   NCBI_TaxID=11777;
OH   NCBI_TaxID=9681; Felidae (cat family).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3007997; DOI=10.1038/320415a0;
RA   Besmer P., Murphy J.E., George P.C., Qiu F., Bergold P.J., Lederman L.,
RA   Snyder H.W. Jr., Brodeur D., Zuckerman E.E., Hardy W.D.;
RT   "A new acute transforming feline retrovirus and relationship of its
RT   oncogene v-kit with the protein kinase gene family.";
RL   Nature 320:415-421(1986).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC         [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC         COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC         ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU10028};
CC   -!- DOMAIN: Lacks the transmembrane and extracellular domains.
CC   -!- MISCELLANEOUS: This protein is synthesized as a Gag-Kit-Pol
CC       polyprotein.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC       kinase family. CSF-1/PDGF receptor subfamily. {ECO:0000255|PROSITE-
CC       ProRule:PRU00159}.
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DR   EMBL; X03711; CAA27339.1; -; Genomic_DNA.
DR   SMR; P04048; -.
DR   BRENDA; 2.7.10.1; 2234.
DR   Proteomes; UP000242259; Genome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:InterPro.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR008266; Tyr_kinase_AS.
DR   InterPro; IPR020635; Tyr_kinase_cat_dom.
DR   InterPro; IPR001824; Tyr_kinase_rcpt_3_CS.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR   SMART; SM00219; TyrKc; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR   PROSITE; PS00240; RECEPTOR_TYR_KIN_III; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Kinase; Nucleotide-binding; Oncogene; Phosphoprotein;
KW   Transferase; Tyrosine-protein kinase.
FT   CHAIN           1..370
FT                   /note="Tyrosine-protein kinase transforming protein kit"
FT                   /id="PRO_0000155208"
FT   DOMAIN          27..370
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   ACT_SITE        230
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
FT                   ECO:0000255|PROSITE-ProRule:PRU10028"
FT   BINDING         33..41
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   BINDING         61
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   MOD_RES         261
FT                   /note="Phosphotyrosine; by autocatalysis"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   370 AA;  41849 MW;  71D32BEDEFE25F2D CRC64;
     EEINGNNYID PTQLPYDHKW EFPRNRLSFG KTLGAGAFGK VVEATAYGLI KSDAAMTVAV
     KMLKPSAHLT EREALMSELK VLSYLGNHMN IVNLLGACTV GGPTLVITEY CCYGDLLNFL
     RRKRDSFICS KQEDHAEVAL YKNLLQSKES SCNDSTNEYM DMKPGVSYVV PTKADKRRSA
     RIGSYIERDV TPAIMEDGEL ALDLEDLLSF SYQVAKGMAF LASKNCIHRD LAARNILLTH
     GRITKICDFG LARDIKNDSN YVVKGNARLP VKWMAPESIF NCVYTFESDV WSYGIFLWEL
     FSLGSSPYPG MPVDSKFYKM IKEGFRMLSP EHAPAEMYDI MKTCWDADPL KRPTFKQIVQ
     LIEKQKNKNE