ID   KIZ_CHICK               Reviewed;         564 AA.
AC   Q5ZK13;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Centrosomal protein kizuna;
DE   AltName: Full=Polo-like kinase 1 substrate 1;
GN   Name=KIZ; Synonyms=PLK1S1; ORFNames=RCJMB04_13o7;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Centrosomal protein required for establishing a robust
CC       mitotic centrosome architecture that can endure the forces that
CC       converge on the centrosomes during spindle formation. Required for
CC       stabilizing the expanded pericentriolar material around the centriole.
CC       {ECO:0000250|UniProtKB:Q2M2Z5}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000250|UniProtKB:Q2M2Z5}. Cytoplasm,
CC       cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q2M2Z5}.
CC   -!- SIMILARITY: Belongs to the kizuna family. {ECO:0000305}.
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DR   EMBL; AJ720271; CAG31930.1; -; mRNA.
DR   RefSeq; NP_001006394.1; NM_001006394.1.
DR   AlphaFoldDB; Q5ZK13; -.
DR   SMR; Q5ZK13; -.
DR   STRING; 9031.ENSGALP00000039221; -.
DR   PaxDb; Q5ZK13; -.
DR   PRIDE; Q5ZK13; -.
DR   Ensembl; ENSGALT00000040014; ENSGALP00000039221; ENSGALG00000008386.
DR   GeneID; 421237; -.
DR   KEGG; gga:421237; -.
DR   CTD; 55857; -.
DR   VEuPathDB; HostDB:geneid_421237; -.
DR   eggNOG; ENOG502R72X; Eukaryota.
DR   GeneTree; ENSGT00390000010121; -.
DR   HOGENOM; CLU_513477_0_0_1; -.
DR   InParanoid; Q5ZK13; -.
DR   OMA; ICESEKR; -.
DR   OrthoDB; 573736at2759; -.
DR   PhylomeDB; Q5ZK13; -.
DR   PRO; PR:Q5ZK13; -.
DR   Proteomes; UP000000539; Chromosome 3.
DR   Bgee; ENSGALG00000008386; Expressed in ovary and 13 other tissues.
DR   ExpressionAtlas; Q5ZK13; baseline and differential.
DR   GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR   GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0007051; P:spindle organization; IBA:GO_Central.
DR   InterPro; IPR026742; Centrosomal_kizuma.
DR   PANTHER; PTHR16299; PTHR16299; 3.
PE   2: Evidence at transcript level;
KW   Cell projection; Coiled coil; Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..564
FT                   /note="Centrosomal protein kizuna"
FT                   /id="PRO_0000381814"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          178..201
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          304..345
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          442..465
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          487..519
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          531..564
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          28..50
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        178..194
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        304..332
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        445..464
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   564 AA;  61474 MW;  B91AD5013840F44C CRC64;
     MSEAGRAAAG PCPEVSPSRS QQLGGLLRCL RDSETRRLEL ERKLMEYKSS DAYLMKLKYV
     KLKKYLEEVN ERQKRALLRN QTFLNEFNEF EAHVKASSSE LIEKMVRYGR EIKSGLSFQE
     GDLARGDKEE GCNEQMPQAA RQAGIHAKTA LSRSLHHPVP FFMGHCMSAC SVQQETPQPA
     ACPNSLTALQ GDETDGHPTQ ADDDMQHANK LDEQGGKSYV PMGEKMSIRD SSLHSSLLNF
     TERKNSTELC SALPDGGSLQ SRTADLASDT SVEEVVTREH LVASAKEVCE QPVLLASAPE
     PSITGPQCNL NTQQAASQDS SSSSTHPEEN YSLQPPSCCA AEDEPLGSSV PEGFCSQDGS
     LKEDLEASEA AVLCQLPEAK SGQQWDVATL QASLNSHTAF LEEHEHLCTE ELAAVLHSTL
     DLDEEAPGSQ APPLLREVLA EECGDGSSVQ SNESSYSLPS IPNDSREVEQ AKHVLWLDSM
     GKQGCVIGNN GSEAKESQEM CSERSSSSER SGDLSRPEFR KGAITAIKSK AFWGESDDSS
     SEAVDALRPQ TRSPEADDFD DFYD