ID   KIZ_DANRE               Reviewed;         706 AA.
AC   A5D8S0;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Centrosomal protein kizuna;
DE   AltName: Full=Polo-like kinase 1 substrate 1;
GN   Name=kiz; Synonyms=plk1s1; ORFNames=zgc:162576;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Centrosomal protein required for establishing a robust
CC       mitotic centrosome architecture that can endure the forces that
CC       converge on the centrosomes during spindle formation. Required for
CC       stabilizing the expanded pericentriolar material around the centriole.
CC       {ECO:0000250|UniProtKB:Q2M2Z5}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000250|UniProtKB:Q2M2Z5}. Cytoplasm,
CC       cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q2M2Z5}.
CC   -!- SIMILARITY: Belongs to the kizuna family. {ECO:0000305}.
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DR   EMBL; BC141787; AAI41788.1; -; mRNA.
DR   RefSeq; NP_001091860.1; NM_001098390.1.
DR   AlphaFoldDB; A5D8S0; -.
DR   SMR; A5D8S0; -.
DR   STRING; 7955.ENSDARP00000102994; -.
DR   PaxDb; A5D8S0; -.
DR   GeneID; 567100; -.
DR   KEGG; dre:567100; -.
DR   CTD; 55857; -.
DR   ZFIN; ZDB-GENE-070615-4; kiz.
DR   eggNOG; ENOG502R72X; Eukaryota.
DR   InParanoid; A5D8S0; -.
DR   OrthoDB; 573736at2759; -.
DR   PhylomeDB; A5D8S0; -.
DR   PRO; PR:A5D8S0; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR   GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0007051; P:spindle organization; ISS:UniProtKB.
DR   InterPro; IPR026742; Centrosomal_kizuma.
DR   PANTHER; PTHR16299; PTHR16299; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Coiled coil; Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..706
FT                   /note="Centrosomal protein kizuna"
FT                   /id="PRO_0000381815"
FT   REGION          105..184
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          215..347
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          571..603
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          620..665
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          677..706
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          63..113
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        127..184
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        215..247
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        272..287
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        310..347
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        574..588
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        624..648
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        649..665
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        685..700
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   706 AA;  79481 MW;  29B464D9E637801F CRC64;
     MAFCNTEYFD QIGNIQKIIH ERERRRHELE ETLFSYLRSD ERLTRLKCAK MRCYAKELHE
     REQRAKTRNL ELLGNVENLA SKLKEFSIDC SRLLQKRMEY KNHITRLKKD RRKMGSRGKS
     EADEHPSRLS TQGLSQSAAI FMGHQTSNGS SRNDGATTKR LPSHTEQIPN HPSLPPSQSG
     LCMHSHVSKA SGAGILSDDI LNSGDFLEGR RLSDVREKQM ESDWDISQRA REQQRQEELK
     SPHTTLKEAE VSSRSVTVNK PADIVSLEHC PTRSPSPDTT DPSDASHYMN SGGEDEEESA
     EDKDDSAPIN QNHSDYTSNI LKPDTSMHSD SDDSASQSQS GHHASRGNAL IQEQSIKAMQ
     THCGSKHKKV STWQSGQHHF SESPNRLSMK GFCHLLKCIE QRLETEDVVN LYRISVNEQN
     LSDDIISICS QRGRLDDIDL HACGAVVLQQ LSMLSCSLPH GCLLPSDLIN SHWSTTSKPQ
     QIRLCLSAES AVLWDCCFTH MVQLQKQKLL STDHIIQLFT PLLLPADATY TDKAGKLLKR
     LLTYKSETHY PSKSESSSSS SLPSLLNDSV EIKPARPSGT NAQTGEEQEI QSAEEDSADQ
     SPVESIPIRE TKAYQLLKQS VAQERHWSDS EEEVSEPPDA HKLEKPEVQQ DILTQNNRKS
     VKTKPFSAVQ SKAFWGESDD SNSEIEMALR PQSCNTSSHD FDDFYD