KIZ_MOUSE
ID KIZ_MOUSE Reviewed; 695 AA.
AC Q3UXL4; A2AUS7; B2RX19;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Centrosomal protein kizuna;
DE AltName: Full=Polo-like kinase 1 substrate 1;
GN Name=Kiz; Synonyms=Gm114, Plk1s1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Muellerian duct;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PROTEIN SEQUENCE OF 73-82; 76-87 AND 132-158, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RC STRAIN=OF1; TISSUE=Hippocampus;
RA Lubec G., Sunyer B., Chen W.-Q.;
RL Submitted (JAN-2009) to UniProtKB.
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-667 AND SER-670, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Centrosomal protein required for establishing a robust
CC mitotic centrosome architecture that can endure the forces that
CC converge on the centrosomes during spindle formation. Required for
CC stabilizing the expanded pericentriolar material around the centriole.
CC {ECO:0000250|UniProtKB:Q2M2Z5}.
CC -!- SUBUNIT: Interacts with AKAP9, CEP72, ODF2, PCNT and TUBGCP2.
CC {ECO:0000250|UniProtKB:Q2M2Z5}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000250|UniProtKB:Q2M2Z5}. Cytoplasm,
CC cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q2M2Z5}.
CC Note=Localizes to centrosomes throughout the cell cycle. After
CC centrosome duplication, it usually remains associated only with the
CC mother centrosome, containing the older mature centriole and particles
CC surrounding it. During prophase, additional particles accumulate around
CC both separating centrosomes. Does not accumulate at the microtubule
CC minus ends, but instead localizes to the centrosomes and
CC centrosome- surrounding area in a microtubule-independent and dependent
CC manner, respectively. {ECO:0000250|UniProtKB:Q2M2Z5}.
CC -!- PTM: Phosphorylation at Thr-391 by PLK1 is not needed for centrosomal
CC localization or pericentriolar material expansion but is indispensable
CC for spindle-pole stabilization. {ECO:0000250|UniProtKB:Q2M2Z5}.
CC -!- SIMILARITY: Belongs to the kizuna family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAM27275.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AK135486; BAE22549.1; -; mRNA.
DR EMBL; AL929215; CAM27275.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL929215; CAM27276.1; -; Genomic_DNA.
DR EMBL; BC150844; AAI50845.1; -; mRNA.
DR EMBL; BC150845; AAI50846.1; -; mRNA.
DR CCDS; CCDS16832.1; -.
DR RefSeq; NP_001028470.1; NM_001033298.3.
DR AlphaFoldDB; Q3UXL4; -.
DR SMR; Q3UXL4; -.
DR IntAct; Q3UXL4; 1.
DR STRING; 10090.ENSMUSP00000096884; -.
DR iPTMnet; Q3UXL4; -.
DR PhosphoSitePlus; Q3UXL4; -.
DR jPOST; Q3UXL4; -.
DR MaxQB; Q3UXL4; -.
DR PaxDb; Q3UXL4; -.
DR PeptideAtlas; Q3UXL4; -.
DR PRIDE; Q3UXL4; -.
DR ProteomicsDB; 263446; -.
DR Antibodypedia; 24776; 136 antibodies from 25 providers.
DR Ensembl; ENSMUST00000099278; ENSMUSP00000096884; ENSMUSG00000074749.
DR GeneID; 228730; -.
DR KEGG; mmu:228730; -.
DR UCSC; uc008mso.1; mouse.
DR CTD; 55857; -.
DR MGI; MGI:2684960; Kiz.
DR VEuPathDB; HostDB:ENSMUSG00000074749; -.
DR eggNOG; ENOG502R72X; Eukaryota.
DR GeneTree; ENSGT00390000010121; -.
DR HOGENOM; CLU_026235_0_0_1; -.
DR InParanoid; Q3UXL4; -.
DR OMA; ICESEKR; -.
DR OrthoDB; 573736at2759; -.
DR PhylomeDB; Q3UXL4; -.
DR TreeFam; TF336086; -.
DR BioGRID-ORCS; 228730; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Kiz; mouse.
DR PRO; PR:Q3UXL4; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q3UXL4; protein.
DR Bgee; ENSMUSG00000074749; Expressed in interventricular septum and 237 other tissues.
DR ExpressionAtlas; Q3UXL4; baseline and differential.
DR Genevisible; Q3UXL4; MM.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0019901; F:protein kinase binding; ISO:MGI.
DR GO; GO:0007051; P:spindle organization; ISS:UniProtKB.
DR InterPro; IPR026742; Centrosomal_kizuma.
DR PANTHER; PTHR16299; PTHR16299; 2.
PE 1: Evidence at protein level;
KW Cell projection; Coiled coil; Cytoplasm; Cytoskeleton;
KW Direct protein sequencing; Phosphoprotein; Reference proteome.
FT CHAIN 1..695
FT /note="Centrosomal protein kizuna"
FT /id="PRO_0000301852"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 261..313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 351..391
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 444..465
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 633..695
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 29..57
FT /evidence="ECO:0000255"
FT COILED 102..132
FT /evidence="ECO:0000255"
FT COMPBIAS 285..303
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 351..382
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 672..688
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 391
FT /note="Phosphothreonine; by PLK1"
FT /evidence="ECO:0000250|UniProtKB:Q2M2Z5"
FT MOD_RES 667
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 670
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 672
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q2M2Z5"
SQ SEQUENCE 695 AA; 76542 MW; 71DDC7CB94FD6EBF CRC64;
MPRGRGGGGG GLRQASATSA PLASPSYYER VGQLQQALRD SEKKRLDLED KLYEYNKSDK
CRAKLKCAKL KKYLKEVCES ERRAQVRNQG YLKKFECVQT YVEHLTTNTE KLQKLKTEYE
AEVKRMRLLS KDSLGMSDED GAKDAVQAGI NSGTAMSRGL YQPATIFMGR QMSAISSIED
FSTELKSNQP TKNFSISDPH SHQQTAQSSC VTDSCVVQTN GDTQCLNKSD KIHGKTSLQT
GEKAPVTSYV LSAEEQTHCL EIGSSTQHSK SNLSEGRKSA ELHSSLQERL SPENSITDLK
CDSSSRSEGS DREILTQEHI EVREERAGPL VPMMAASEHC TSAKKWAGEK HSAWEASSDD
LDHGDSKSQK AVLKHEEEQE EGSSCSSSDL TVSVSEDDLI LESLAALSNP GAKMAGKDGM
QALRAAHTEP RQDSLFTEYV LQTQSFPDSK REPSPDSPRQ PEKVPDCHLL KTRGQCMKEH
DNSLKEEATT LLKKVLTEEC DHRSAIHSNE SSCSMPSILN DNNGIKEAKP ALRLNSVLTR
EQEVSSGCGD ESKEESIAAA PGTGHREADL VPSELFQFSL GAAMKETKAY QLLKKSTLQD
NSNQAEERFE SQFSGLDIGG SMFTTKTAHK IASEASFSSS EGSPLSRHES KRDPVTTIKS
NAFWGESDDS NSEIEAALRP RDHDMPDDFD DFYDT
