KKLC1_HUMAN
ID KKLC1_HUMAN Reviewed; 113 AA.
AC Q5H943;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Kita-kyushu lung cancer antigen 1;
DE Short=KK-LC-1;
DE AltName: Full=Cancer/testis antigen 83;
GN Name=CT83; Synonyms=CXorf61, KKLC1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP TOPOLOGY, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND IDENTIFICATION AS A
RP CANCER/TESTIS ANTIGEN.
RX PubMed=16651449; DOI=10.1158/0008-5472.can-05-3840;
RA Fukuyama T., Hanagiri T., Takenoyama M., Ichiki Y., Mizukami M., So T.,
RA Sugaya M., So T., Sugio K., Yasumoto K.;
RT "Identification of a new cancer/germline gene, KK-LC-1, encoding an antigen
RT recognized by autologous CTL induced on human lung adenocarcinoma.";
RL Cancer Res. 66:4922-4928(2006).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16651449};
CC Single-pass type II membrane protein {ECO:0000269|PubMed:16651449}.
CC -!- TISSUE SPECIFICITY: Specifically expressed in testis. Expressed by
CC cancer cell lines. {ECO:0000269|PubMed:16651449}.
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DR EMBL; Z96810; CAI42798.1; -; Genomic_DNA.
DR EMBL; BC062223; AAH62223.1; -; mRNA.
DR CCDS; CCDS35372.1; -.
DR RefSeq; NP_001017978.1; NM_001017978.3.
DR AlphaFoldDB; Q5H943; -.
DR SMR; Q5H943; -.
DR STRING; 9606.ENSP00000360961; -.
DR GlyGen; Q5H943; 1 site.
DR iPTMnet; Q5H943; -.
DR PhosphoSitePlus; Q5H943; -.
DR BioMuta; CT83; -.
DR EPD; Q5H943; -.
DR jPOST; Q5H943; -.
DR MassIVE; Q5H943; -.
DR MaxQB; Q5H943; -.
DR PaxDb; Q5H943; -.
DR PeptideAtlas; Q5H943; -.
DR PRIDE; Q5H943; -.
DR ProteomicsDB; 62868; -.
DR Antibodypedia; 591; 56 antibodies from 19 providers.
DR DNASU; 203413; -.
DR Ensembl; ENST00000371894.5; ENSP00000360961.4; ENSG00000204019.5.
DR GeneID; 203413; -.
DR KEGG; hsa:203413; -.
DR MANE-Select; ENST00000371894.5; ENSP00000360961.4; NM_001017978.4; NP_001017978.1.
DR UCSC; uc004eqj.3; human.
DR CTD; 203413; -.
DR DisGeNET; 203413; -.
DR GeneCards; CT83; -.
DR HGNC; HGNC:33494; CT83.
DR HPA; ENSG00000204019; Tissue enriched (testis).
DR MIM; 300625; gene.
DR neXtProt; NX_Q5H943; -.
DR OpenTargets; ENSG00000204019; -.
DR PharmGKB; PA162383081; -.
DR VEuPathDB; HostDB:ENSG00000204019; -.
DR eggNOG; ENOG502TE5A; Eukaryota.
DR GeneTree; ENSGT00390000018873; -.
DR HOGENOM; CLU_168652_0_0_1; -.
DR InParanoid; Q5H943; -.
DR OMA; PRSIAMQ; -.
DR OrthoDB; 1601432at2759; -.
DR PhylomeDB; Q5H943; -.
DR SignaLink; Q5H943; -.
DR BioGRID-ORCS; 203413; 27 hits in 681 CRISPR screens.
DR GenomeRNAi; 203413; -.
DR Pharos; Q5H943; Tbio.
DR PRO; PR:Q5H943; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q5H943; protein.
DR Bgee; ENSG00000204019; Expressed in sperm and 78 other tissues.
DR Genevisible; Q5H943; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; HDA:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR027940; KKLCAg1.
DR PANTHER; PTHR38650; PTHR38650; 1.
DR Pfam; PF15204; KKLCAg1; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Glycoprotein; Membrane; Reference proteome; Signal-anchor;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..113
FT /note="Kita-kyushu lung cancer antigen 1"
FT /id="PRO_0000293736"
FT TOPO_DOM 1..3
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 4..21
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 22..113
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT CARBOHYD 83
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 113 AA; 12784 MW; 7BC40E0AFFAC587A CRC64;
MNFYLLLASS ILCALIVFWK YRRFQRNTGE MSSNSTALAL VRPSSSGLIN SNTDNNLAVY
DLSRDILNNF PHSIARQKRI LVNLSMVENK LVELEHTLLS KGFRGASPHR KST
