ID   KKX26_OPICY             Reviewed;          65 AA.
AC   C5J893;
DT   19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 23.
DE   RecName: Full=Potassium channel toxin kappa-KTx 2.6 {ECO:0000303|PubMed:22305749};
DE   AltName: Full=OcyC9 {ECO:0000303|PubMed:19379768};
DE   Flags: Precursor;
OS   Opisthacanthus cayaporum (South American scorpion).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Iurida; Scorpionoidea; Hemiscorpiidae; Opisthacanthus.
OX   NCBI_TaxID=573324;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=19379768; DOI=10.1016/j.toxicon.2009.04.010;
RA   Silva E.C., Camargos T.S., Maranhao A.Q., Silva-Pereira I., Silva L.P.,
RA   Possani L.D., Schwartz E.F.;
RT   "Cloning and characterization of cDNA sequences encoding for new venom
RT   peptides of the Brazilian scorpion Opisthacanthus cayaporum.";
RL   Toxicon 54:252-261(2009).
RN   [2]
RP   NOMENCLATURE.
RX   PubMed=22305749; DOI=10.1016/j.bcp.2012.01.021;
RA   Vandendriessche T., Kopljar I., Jenkins D.P., Diego-Garcia E.,
RA   Abdel-Mottaleb Y., Vermassen E., Clynen E., Schoofs L., Wulff H.,
RA   Snyders D., Tytgat J.;
RT   "Purification, molecular cloning and functional characterization of HelaTx1
RT   (Heterometrus laoticus): the first member of a new kappa-KTX subfamily.";
RL   Biochem. Pharmacol. 83:1307-1317(2012).
CC   -!- FUNCTION: Potassium channel inhibitor (Kv). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- DOMAIN: Has the structural arrangement of two alpha-helices stabilized
CC       by disulfide bonds (CSalpha/alpha 2(S-S)).
CC       {ECO:0000250|UniProtKB:P0C1Z3}.
CC   -!- SIMILARITY: Belongs to the short scorpion toxin superfamily. Potassium
CC       channel inhibitor kappa-KTx family. Kappa-KTx 2 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; FM998751; CAX51397.1; -; mRNA.
DR   AlphaFoldDB; C5J893; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond;
KW   Ion channel impairing toxin; Neurotoxin; Potassium channel impairing toxin;
KW   Secreted; Signal; Toxin; Voltage-gated potassium channel impairing toxin.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   PROPEP          28..39
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000416795"
FT   PEPTIDE         42..65
FT                   /note="Potassium channel toxin kappa-KTx 2.6"
FT                   /id="PRO_0000413157"
FT   DISULFID        45..63
FT                   /evidence="ECO:0000250|UniProtKB:P0C1Z3"
FT   DISULFID        49..59
FT                   /evidence="ECO:0000250|UniProtKB:P0C1Z3"
SQ   SEQUENCE   65 AA;  7229 MW;  9A543F7E1EF2D790 CRC64;
     MKTSKMICAF LLVLVVGTFN DISGAYGEYV EDQHSFKIER RFPPCVEVCV QHTGNVKECE
     AACGE