ARAE1_ORYSJ
ID ARAE1_ORYSJ Reviewed; 421 AA.
AC Q8H930; A0A0P0X238; Q0D8Q0; Q8GVZ4;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 2.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Probable UDP-arabinose 4-epimerase 1;
DE EC=5.1.3.5;
DE AltName: Full=OsUEL-1;
DE AltName: Full=UDP-D-xylose 4-epimerase 1;
DE AltName: Full=UDP-galactose 4-epimerase-like protein 1;
GN Name=UEL-1;
GN OrderedLocusNames=Os07g0139400 {ECO:0000312|EMBL:BAF20773.1},
GN LOC_Os07g04690 {ECO:0000305};
GN ORFNames=OJ1417_E01.121, OsJ_23039 {ECO:0000312|EMBL:EEE66539.1},
GN P0495H05.61;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Nipponbare; TISSUE=Immature seed;
RA Suzuki K., Kitamura S.;
RT "Cloning of UDP-glucose 4-epimerase-like genes in Oryza sativa.";
RL Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=UDP-beta-L-arabinopyranose = UDP-alpha-D-xylose;
CC Xref=Rhea:RHEA:11320, ChEBI:CHEBI:57632, ChEBI:CHEBI:61457;
CC EC=5.1.3.5;
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540; Evidence={ECO:0000250};
CC -!- PATHWAY: Nucleotide-sugar biosynthesis; UDP-L-arabinose biosynthesis;
CC UDP-L-arabinose from UDP-alpha-D-xylose: step 1/1.
CC -!- PATHWAY: Cell wall biogenesis; cell wall polysaccharide biosynthesis.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane
CC {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC45055.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAC83501.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB096864; BAC24804.1; -; mRNA.
DR EMBL; AP003829; BAC45055.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP004314; BAC83501.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP008213; BAF20773.1; -; Genomic_DNA.
DR EMBL; AP014963; BAS99996.1; -; Genomic_DNA.
DR EMBL; CM000144; EEE66539.1; -; Genomic_DNA.
DR RefSeq; XP_015647690.1; XM_015792204.1.
DR AlphaFoldDB; Q8H930; -.
DR SMR; Q8H930; -.
DR STRING; 4530.OS07T0139400-01; -.
DR PaxDb; Q8H930; -.
DR PRIDE; Q8H930; -.
DR EnsemblPlants; Os07t0139400-01; Os07t0139400-01; Os07g0139400.
DR EnsemblPlants; Os07t0139400-02; Os07t0139400-02; Os07g0139400.
DR GeneID; 4342364; -.
DR Gramene; Os07t0139400-01; Os07t0139400-01; Os07g0139400.
DR Gramene; Os07t0139400-02; Os07t0139400-02; Os07g0139400.
DR KEGG; osa:4342364; -.
DR eggNOG; KOG1371; Eukaryota.
DR HOGENOM; CLU_007383_1_10_1; -.
DR InParanoid; Q8H930; -.
DR OMA; DGELGEW; -.
DR OrthoDB; 662484at2759; -.
DR PlantReactome; R-OSA-1119428; GDP-D-rhamnose biosynthesis.
DR PlantReactome; R-OSA-1119574; UDP-L-arabinose biosynthesis and transport.
DR PlantReactome; R-OSA-1119620; GDP-L-fucose biosynthesis I (from GDP-D-mannose).
DR UniPathway; UPA00797; UER00772.
DR UniPathway; UPA00963; -.
DR Proteomes; UP000000763; Chromosome 7.
DR Proteomes; UP000007752; Chromosome 7.
DR Proteomes; UP000059680; Chromosome 7.
DR ExpressionAtlas; Q8H930; baseline and differential.
DR Genevisible; Q8H930; OS.
DR GO; GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0050373; F:UDP-arabinose 4-epimerase activity; IEA:UniProtKB-EC.
DR GO; GO:0003978; F:UDP-glucose 4-epimerase activity; IEA:InterPro.
DR GO; GO:0045227; P:capsule polysaccharide biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006012; P:galactose metabolic process; IEA:InterPro.
DR GO; GO:0033358; P:UDP-L-arabinose biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd05247; UDP_G4E_1_SDR_e; 1.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR005886; UDP_G4E.
DR Pfam; PF16363; GDP_Man_Dehyd; 1.
DR SUPFAM; SSF51735; SSF51735; 1.
DR TIGRFAMs; TIGR01179; galE; 1.
PE 2: Evidence at transcript level;
KW Carbohydrate metabolism; Golgi apparatus; Isomerase; Membrane; NAD;
KW Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix.
FT CHAIN 1..421
FT /note="Probable UDP-arabinose 4-epimerase 1"
FT /id="PRO_0000183233"
FT TOPO_DOM 1..33
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 34..53
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 54..421
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT ACT_SITE 222
FT /note="Proton acceptor"
FT /evidence="ECO:0000250"
FT BINDING 74..105
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000250"
FT CONFLICT 220
FT /note="N -> S (in Ref. 1; BAC24804)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 421 AA; 46773 MW; 1AB387CACB94051A CRC64;
MLPTNRNRPQ QRPARSWYFI SDMDFSDPKR KPRYLSKILM VALLTAMCVV MLTQPPCHRR
TPSVFSIHEP GVTHVLVTGG AGYIGSHAAL RLLKDSFRVT IVDNLSRGNM GAIKVLQNLF
SEPGRLQFIY ADLGDPKAVN RIFAENAFDA VMHFAAVAYV GESTLEPLRY YHNITSNTLV
VLEAMAAHNV RTLIYSSTCA TYGEPEKMPI TEGTPQFPIN PYGKAKKMAE DIILDFSKSK
KADMAVMILR YFNVIGSDPE GRLGEAPKPE LREHGRISGA CFDAALGIIP GLKVKGTDYE
TPDGTCVRDY IDVTDLVDAH VKALNKAERG KVGIYNVGTG KGRSVKEFVE ACKKATGVDI
KVDYFPRRPG DYAEVYSDPA KINSELNWTA QHTDLLESLR VAWTWQKKHR SGYGPPQAMV
L
