KLCR1_ARATH
ID KLCR1_ARATH Reviewed; 609 AA.
AC O81629; F4JMG6; Q8LCN6;
DT 30-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 25-MAY-2022, entry version 164.
DE RecName: Full=Protein KINESIN LIGHT CHAIN-RELATED 1 {ECO:0000303|PubMed:23204523};
GN Name=KLCR1 {ECO:0000303|PubMed:23204523};
GN OrderedLocusNames=At4g10840 {ECO:0000312|Araport:AT4G10840};
GN ORFNames=F25I24.50 {ECO:0000312|EMBL:CAB40052.1},
GN F8M12.21 {ECO:0000312|EMBL:AAC33943.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP INTERACTION WITH IQD1, SUBCELLULAR LOCATION, GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=23204523; DOI=10.1074/jbc.m112.396200;
RA Buerstenbinder K., Savchenko T., Mueller J., Adamson A.W., Stamm G.,
RA Kwong R., Zipp B.J., Dinesh D.C., Abel S.;
RT "Arabidopsis calmodulin-binding protein IQ67-domain 1 localizes to
RT microtubules and interacts with kinesin light chain-related protein-1.";
RL J. Biol. Chem. 288:1871-1882(2013).
RN [6]
RP REVIEW.
RX PubMed=23531692; DOI=10.4161/psb.24369;
RA Abel S., Buerstenbinder K., Mueller J.;
RT "The emerging function of IQD proteins as scaffolds in cellular signaling
RT and trafficking.";
RL Plant Signal. Behav. 8:E24369-E24369(2013).
CC -!- SUBUNIT: Interacts with IQD1. {ECO:0000269|PubMed:23204523}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000269|PubMed:23204523}. Cytoplasm {ECO:0000269|PubMed:23204523}.
CC Note=Recruited by IQD1 to microtubules. {ECO:0000269|PubMed:23204523}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=O81629-1; Sequence=Displayed;
CC Name=2;
CC IsoId=O81629-2; Sequence=VSP_058634;
CC -!- SIMILARITY: Belongs to the kinesin light chain family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM63491.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AF080118; AAC33943.1; -; Genomic_DNA.
DR EMBL; AL049525; CAB40052.1; -; Genomic_DNA.
DR EMBL; AL161518; CAB81185.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE82933.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE82934.1; -; Genomic_DNA.
DR EMBL; AY072170; AAL59992.1; -; mRNA.
DR EMBL; AY090361; AAL91265.1; -; mRNA.
DR EMBL; BT000987; AAN41387.1; -; mRNA.
DR EMBL; AY086489; AAM63491.1; ALT_INIT; mRNA.
DR PIR; T01892; T01892.
DR RefSeq; NP_192822.1; NM_117152.5. [O81629-1]
DR RefSeq; NP_974530.1; NM_202801.1. [O81629-2]
DR AlphaFoldDB; O81629; -.
DR SMR; O81629; -.
DR IntAct; O81629; 6.
DR STRING; 3702.AT4G10840.1; -.
DR iPTMnet; O81629; -.
DR PaxDb; O81629; -.
DR PRIDE; O81629; -.
DR ProteomicsDB; 230371; -. [O81629-1]
DR EnsemblPlants; AT4G10840.1; AT4G10840.1; AT4G10840. [O81629-1]
DR EnsemblPlants; AT4G10840.2; AT4G10840.2; AT4G10840. [O81629-2]
DR GeneID; 826680; -.
DR Gramene; AT4G10840.1; AT4G10840.1; AT4G10840. [O81629-1]
DR Gramene; AT4G10840.2; AT4G10840.2; AT4G10840. [O81629-2]
DR KEGG; ath:AT4G10840; -.
DR Araport; AT4G10840; -.
DR TAIR; locus:2123411; AT4G10840.
DR eggNOG; KOG1840; Eukaryota.
DR HOGENOM; CLU_021284_1_0_1; -.
DR InParanoid; O81629; -.
DR OMA; SIGCYEE; -.
DR PhylomeDB; O81629; -.
DR PRO; PR:O81629; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; O81629; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005829; C:cytosol; HDA:TAIR.
DR GO; GO:0005874; C:microtubule; IDA:UniProtKB.
DR Gene3D; 1.25.40.10; -; 3.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR041617; TPR_MalT.
DR InterPro; IPR019734; TPR_repeat.
DR Pfam; PF17874; TPR_MalT; 1.
DR SMART; SM00028; TPR; 9.
DR SUPFAM; SSF48452; SSF48452; 3.
DR PROSITE; PS50005; TPR; 9.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Cytoskeleton; Reference proteome; Repeat;
KW TPR repeat.
FT CHAIN 1..609
FT /note="Protein KINESIN LIGHT CHAIN-RELATED 1"
FT /id="PRO_0000438247"
FT REPEAT 140..173
FT /note="TPR 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00339"
FT REPEAT 183..216
FT /note="TPR 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00339"
FT REPEAT 225..258
FT /note="TPR 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00339"
FT REPEAT 267..301
FT /note="TPR 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00339"
FT REPEAT 307..340
FT /note="TPR 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00339"
FT REPEAT 349..382
FT /note="TPR 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00339"
FT REPEAT 392..425
FT /note="TPR 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00339"
FT REPEAT 433..466
FT /note="TPR 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00339"
FT REPEAT 474..507
FT /note="TPR 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00339"
FT REPEAT 516..549
FT /note="TPR 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00339"
FT REGION 1..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 582..609
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..72
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 532..609
FT /note="Missing (in isoform 2)"
FT /id="VSP_058634"
SQ SEQUENCE 609 AA; 66281 MW; 18A1B2266B568879 CRC64;
MPAMPGLVSV KTPSDTPPLR VAVPDTQPLS NPPRTPMKKT PSSTPSRSKP SPNRSTGKKD
SPTVSSSTAA VIDVDDPSLD NPDLGPFLLK LARDAIASGE GPNKALDYAI RATKSFERCC
AAVAPPIPGG SDGGPVLDLA MSLHVLAAIY CSLGRFDEAV PPLERAIQVP DPTRGPDHSL
AAFSGHMQLG DTLSMLGQID RSIACYEEGL KIQIQTLGDT DPRVGETCRY LAEAYVQAMQ
FNKAEELCKK TLEIHRAHSE PASLEEAADR RLMAIICEAK GDYENALEHL VLASMAMIAS
GQESEVASID VSIGNIYMSL CRFDEAVFSY QKALTVFKAS KGETHPTVAS VFVRLAELYH
RTGKLRESKS YCENALRIYN KPVPGTTVEE IAGGLTEISA IYESVDEPEE ALKLLQKSMK
LLEDKPGQQS AIAGLEARMG VMYYTVGRYE DARNAFESAV TKLRAAGEKS AFFGVVLNQM
GLACVQLFKI DEAGELFEEA RGILEQERGP CDQDTLGVYS NLAATYDAMG RIEDAIEILE
QVLKLREEKL GTANPDFEDE KKRLAELLKE AGRSRNYKAK SLQNLIDPNA RPPKKESSAK
KWPSLGFKF
