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ARAE2_ORYSJ
ID   ARAE2_ORYSJ             Reviewed;         391 AA.
AC   Q8H0B6; B7EBH1; Q7X8J9;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Probable UDP-arabinose 4-epimerase 2;
DE            EC=5.1.3.5;
DE   AltName: Full=OsUEL-2;
DE   AltName: Full=UDP-D-xylose 4-epimerase 2;
DE   AltName: Full=UDP-galactose 4-epimerase-like protein 2;
GN   Name=UEL-2; OrderedLocusNames=Os04g0618200, LOC_Os04g52730;
GN   ORFNames=OsJ_16180 {ECO:0000312|EMBL:EEE61700.1}, OSJNBa0058K23.4,
GN   OSJNBa0093O08.14;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Nipponbare; TISSUE=Immature seed;
RA   Suzuki K., Kitamura S.;
RT   "Cloning of UDP-glucose 4-epimerase-like genes in Oryza sativa.";
RL   Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12447439; DOI=10.1038/nature01183;
RA   Feng Q., Zhang Y., Hao P., Wang S., Fu G., Huang Y., Li Y., Zhu J., Liu Y.,
RA   Hu X., Jia P., Zhang Y., Zhao Q., Ying K., Yu S., Tang Y., Weng Q.,
RA   Zhang L., Lu Y., Mu J., Lu Y., Zhang L.S., Yu Z., Fan D., Liu X., Lu T.,
RA   Li C., Wu Y., Sun T., Lei H., Li T., Hu H., Guan J., Wu M., Zhang R.,
RA   Zhou B., Chen Z., Chen L., Jin Z., Wang R., Yin H., Cai Z., Ren S., Lv G.,
RA   Gu W., Zhu G., Tu Y., Jia J., Zhang Y., Chen J., Kang H., Chen X., Shao C.,
RA   Sun Y., Hu Q., Zhang X., Zhang W., Wang L., Ding C., Sheng H., Gu J.,
RA   Chen S., Ni L., Zhu F., Chen W., Lan L., Lai Y., Cheng Z., Gu M., Jiang J.,
RA   Li J., Hong G., Xue Y., Han B.;
RT   "Sequence and analysis of rice chromosome 4.";
RL   Nature 420:316-320(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA   Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA   Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA   Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA   Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA   Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA   Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA   Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA   Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA   Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA   Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA   Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA   Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA   Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA   McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT   "The genomes of Oryza sativa: a history of duplications.";
RL   PLoS Biol. 3:266-281(2005).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=UDP-beta-L-arabinopyranose = UDP-alpha-D-xylose;
CC         Xref=Rhea:RHEA:11320, ChEBI:CHEBI:57632, ChEBI:CHEBI:61457;
CC         EC=5.1.3.5;
CC   -!- COFACTOR:
CC       Name=NAD(+); Xref=ChEBI:CHEBI:57540; Evidence={ECO:0000250};
CC   -!- PATHWAY: Nucleotide-sugar biosynthesis; UDP-L-arabinose biosynthesis;
CC       UDP-L-arabinose from UDP-alpha-D-xylose: step 1/1.
CC   -!- PATHWAY: Cell wall biogenesis; cell wall polysaccharide biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane
CC       {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC       family. {ECO:0000305}.
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DR   EMBL; AB097461; BAC41500.1; -; mRNA.
DR   EMBL; AL606648; CAD41895.2; -; Genomic_DNA.
DR   EMBL; AL662970; CAD41738.2; -; Genomic_DNA.
DR   EMBL; AP014960; BAS91033.1; -; Genomic_DNA.
DR   EMBL; CM000141; EEE61700.1; -; Genomic_DNA.
DR   EMBL; AK065875; BAG89718.1; -; mRNA.
DR   EMBL; AK102657; BAG95662.1; -; mRNA.
DR   RefSeq; XP_015634966.1; XM_015779480.1.
DR   AlphaFoldDB; Q8H0B6; -.
DR   SMR; Q8H0B6; -.
DR   STRING; 4530.OS04T0618200-02; -.
DR   PaxDb; Q8H0B6; -.
DR   PRIDE; Q8H0B6; -.
DR   EnsemblPlants; Os04t0618200-01; Os04t0618200-01; Os04g0618200.
DR   EnsemblPlants; Os04t0618200-02; Os04t0618200-02; Os04g0618200.
DR   GeneID; 4337011; -.
DR   Gramene; Os04t0618200-01; Os04t0618200-01; Os04g0618200.
DR   Gramene; Os04t0618200-02; Os04t0618200-02; Os04g0618200.
DR   KEGG; osa:4337011; -.
DR   eggNOG; KOG1371; Eukaryota.
DR   HOGENOM; CLU_007383_1_10_1; -.
DR   InParanoid; Q8H0B6; -.
DR   OMA; EACKMAT; -.
DR   OrthoDB; 662484at2759; -.
DR   PlantReactome; R-OSA-1119428; GDP-D-rhamnose biosynthesis.
DR   PlantReactome; R-OSA-1119574; UDP-L-arabinose biosynthesis and transport.
DR   PlantReactome; R-OSA-1119620; GDP-L-fucose biosynthesis I (from GDP-D-mannose).
DR   UniPathway; UPA00797; UER00772.
DR   UniPathway; UPA00963; -.
DR   Proteomes; UP000000763; Chromosome 4.
DR   Proteomes; UP000007752; Chromosome 4.
DR   Proteomes; UP000059680; Chromosome 4.
DR   Genevisible; Q8H0B6; OS.
DR   GO; GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0050373; F:UDP-arabinose 4-epimerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0003978; F:UDP-glucose 4-epimerase activity; IEA:InterPro.
DR   GO; GO:0045227; P:capsule polysaccharide biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006012; P:galactose metabolic process; IEA:InterPro.
DR   GO; GO:0033358; P:UDP-L-arabinose biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd05247; UDP_G4E_1_SDR_e; 1.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR005886; UDP_G4E.
DR   Pfam; PF16363; GDP_Man_Dehyd; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR01179; galE; 1.
PE   2: Evidence at transcript level;
KW   Carbohydrate metabolism; Golgi apparatus; Isomerase; Membrane; NAD;
KW   Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix.
FT   CHAIN           1..391
FT                   /note="Probable UDP-arabinose 4-epimerase 2"
FT                   /id="PRO_0000183234"
FT   TOPO_DOM        1..9
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        10..30
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        31..391
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        199
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
FT   BINDING         51..82
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   391 AA;  42784 MW;  8F9F0F7AD2122225 CRC64;
     MDFGDSRRKP NVVGKFTVAV ALTVMCIIVL KQSPGFTSTS VFSRHEIGVT HVLVTGGAGY
     IGSHATLRLL RDNYRVTIVD NLSRGNMGAV RVLQRLFPEP GRLQFIYADL GDAKAVNKIF
     SENAFDAVMH FAAVAYVGES TLEPLRYYHN ITSNTLTVLE AMAAYNVKTL IYSSTCATYG
     EPDTMPITEA TPQNPINPYG KAKKMAEDII LDFSKRSEMA VMILRYFNVI GSDPGGRLGE
     APRPELREHG RISGACFDAA LGIIPGLKVR GTDYPTADGT CIRDYIDVTD LVDAHVKALD
     KAQPGKVGIY NVGTGHGRSV KEFVEACKSA TGASIKVSFL TRRPGDYAEV YSDPSKIHDE
     LNWTARYIDL RESLSTAWKW QKAHPNGYGS A
 
 
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