KLD10_DROME
ID KLD10_DROME Reviewed; 609 AA.
AC A1ZB86; Q7JR76;
DT 16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT 11-MAY-2016, sequence version 2.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Kelch domain-containing protein 10 homolog;
DE AltName: Full=Scruin like at the midline;
GN Name=slim; ORFNames=CG5186;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Butland B.M., Russell C., Tear G.;
RT "Slim, a kelch repeat molecule expressed at the midline of the Drosophila
RT CNS.";
RL Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo, and Testis;
RA Stapleton M., Brokstein P., Hong L., Agbayani A., Booth B., Carlson J.,
RA Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E.,
RA George R., Gonzalez M., Guarin H., Kronmiller B., Li P., Liao G.,
RA Miranda A., Mungall C.J., Nunoo J., Pacleb J., Paragas V., Park S.,
RA Patel S., Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M.,
RA Celniker S.E.;
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP FUNCTION, AND INTERACTION WITH ELONGIN-C.
RX PubMed=23102700; DOI=10.1016/j.molcel.2012.09.018;
RA Sekine Y., Hatanaka R., Watanabe T., Sono N., Iemura S., Natsume T.,
RA Kuranaga E., Miura M., Takeda K., Ichijo H.;
RT "The Kelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1
RT activation by suppressing PP5.";
RL Mol. Cell 48:692-704(2012).
CC -!- FUNCTION: Activates the Pk92B/DASK1-MAPK signaling cascade.
CC {ECO:0000269|PubMed:23102700}.
CC -!- SUBUNIT: Interacts with Elongin-C; may be the substrate recognition
CC component of an E3 ubiquitin ligase complex.
CC {ECO:0000269|PubMed:23102700}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AEW12888.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AF239722; AAK82959.1; -; mRNA.
DR EMBL; AE013599; AAF57686.1; -; Genomic_DNA.
DR EMBL; AE013599; AAM68458.3; -; Genomic_DNA.
DR EMBL; BT132916; AEW12888.1; ALT_INIT; mRNA.
DR EMBL; BT003216; AAO24971.1; -; mRNA.
DR EMBL; BT125963; ADX35942.1; -; mRNA.
DR RefSeq; NP_523782.1; NM_079058.3.
DR RefSeq; NP_725794.2; NM_166289.2.
DR AlphaFoldDB; A1ZB86; -.
DR SMR; A1ZB86; -.
DR BioGRID; 62797; 9.
DR IntAct; A1ZB86; 1.
DR STRING; 7227.FBpp0085872; -.
DR PaxDb; A1ZB86; -.
DR PRIDE; A1ZB86; -.
DR DNASU; 37121; -.
DR EnsemblMetazoa; FBtr0086693; FBpp0085872; FBgn0261477.
DR EnsemblMetazoa; FBtr0331958; FBpp0304290; FBgn0261477.
DR GeneID; 37121; -.
DR KEGG; dme:Dmel_CG5186; -.
DR UCSC; CG5186-RA; d. melanogaster.
DR UCSC; CG5186-RB; d. melanogaster.
DR CTD; 37121; -.
DR FlyBase; FBgn0261477; slim.
DR VEuPathDB; VectorBase:FBgn0261477; -.
DR eggNOG; KOG0379; Eukaryota.
DR GeneTree; ENSGT00390000003374; -.
DR HOGENOM; CLU_030914_0_0_1; -.
DR InParanoid; A1ZB86; -.
DR OMA; HYLYTIG; -.
DR OrthoDB; 397156at2759; -.
DR PhylomeDB; A1ZB86; -.
DR BioGRID-ORCS; 37121; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 37121; -.
DR PRO; PR:A1ZB86; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0261477; Expressed in embryonic/larval hemocyte (Drosophila) and 56 other tissues.
DR ExpressionAtlas; A1ZB86; baseline and differential.
DR Genevisible; A1ZB86; DM.
DR GO; GO:0031462; C:Cul2-RING ubiquitin ligase complex; IDA:FlyBase.
DR GO; GO:0032874; P:positive regulation of stress-activated MAPK cascade; IDA:FlyBase.
DR Gene3D; 2.120.10.80; -; 2.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR Pfam; PF01344; Kelch_1; 1.
DR SUPFAM; SSF117281; SSF117281; 2.
PE 1: Evidence at protein level;
KW Kelch repeat; Reference proteome; Repeat.
FT CHAIN 1..609
FT /note="Kelch domain-containing protein 10 homolog"
FT /id="PRO_0000424032"
FT REPEAT 214..277
FT /note="Kelch 1"
FT REPEAT 279..334
FT /note="Kelch 2"
FT REPEAT 335..381
FT /note="Kelch 3"
FT REPEAT 389..437
FT /note="Kelch 4"
FT REPEAT 458..508
FT /note="Kelch 5"
FT REPEAT 510..554
FT /note="Kelch 6"
FT REGION 103..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 576..609
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 589..609
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 609 AA; 69676 MW; 62009F358E44FCFE CRC64;
MNILNPGKFK CIVFDQLRHT WTFLLFICDF LAKIYRTPRI TAHQEQLANH NNNNNNNNDL
IMEQDMPEEE VGQPEEALPQ QDNGEVVDRF NAIQAAVELM DAASDLDEEE EEEDDDVDVD
VDYGDTDSES EFEEMYSDEW TSSSDELDEG TELSKSVLNV FLSSDKQQSQ MAGQIPMYAF
QPLRLVKCQY RDKHIPGGFP LARSGHRIIA SNSHLYSLGG YNPRSAMSAS RHGRCLLFQE
LWSYNFATRT WRLELNAGNA ANMPVELASN ALTIHNNVLI SHGGTGYPFG VSCSNDCYVY
RTASAGATPG VDRLQVKGDL PTAQYGPGIV IHKHFLYTIG GTTGFDYTCD VYRLDLRTGI
WENVYISRPE MRDDPEGRYR HEVVYDGKHI FVLGGGTSHS VYDLQRIPAY NLEANCWDYF
ETYPDQRAAD ADDGNRGYPK PRKCFSCVQH QSSTGDIEAF ITGGLQGDFS TYFSDIWKLN
LRTKHWYRIE TAILPRPLYF HSAAHSDNGC MYVFGGIEYI DKEMRRRNDL YKMWMTVPKL
SEMCWDAITY YNDNLDLYDR KTLLEAGIPK RFTERLPPQR RRRLDTSQPD PSMLISLYSN
PKRARSSTQ
