ID   KLD10_XENLA             Reviewed;         411 AA.
AC   Q5U580;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Kelch domain-containing protein 10 {ECO:0000305};
GN   Name=klhdc10 {ECO:0000250|UniProtKB:Q6PID8};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Substrate-recognition component of a Cul2-RING (CRL2) E3
CC       ubiquitin-protein ligase complex of the DesCEND (destruction via C-end
CC       degrons) pathway, which recognizes a C-degron located at the extreme C
CC       terminus of target proteins, leading to their ubiquitination and
CC       degradation. The C-degron recognized by the DesCEND pathway is usually
CC       a motif of less than ten residues and can be present in full-length
CC       proteins, truncated proteins or proteolytically cleaved forms. The
CC       CRL2(KLHDC10) complex specifically recognizes proteins with a proline-
CC       glycine (Pro-Gly) at the C-terminus, leading to their ubiquitination
CC       and degradation. Participates in the oxidative stress-induced cell
CC       death through MAP3K5 activation. {ECO:0000250|UniProtKB:Q6PID8}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000250|UniProtKB:Q6PID8}.
CC   -!- SUBUNIT: Component of a CRL2 E3 ubiquitin-protein ligase complex, also
CC       named ECS (Elongin BC-CUL2/5-SOCS-box protein) complex, composed of
CC       CUL2, Elongin BC (ELOB and ELOC), RBX1 and substrate-specific adapter
CC       KLHDC10. {ECO:0000250|UniProtKB:Q6PID8}.
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DR   EMBL; BC084804; AAH84804.1; -; mRNA.
DR   RefSeq; NP_001088477.1; NM_001095008.1.
DR   AlphaFoldDB; Q5U580; -.
DR   SMR; Q5U580; -.
DR   MaxQB; Q5U580; -.
DR   PRIDE; Q5U580; -.
DR   DNASU; 495342; -.
DR   GeneID; 495342; -.
DR   KEGG; xla:495342; -.
DR   CTD; 495342; -.
DR   Xenbase; XB-GENE-6253965; klhdc10.L.
DR   OrthoDB; 564212at2759; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 495342; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   Gene3D; 2.120.10.80; -; 2.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   Pfam; PF01344; Kelch_1; 1.
DR   SMART; SM00612; Kelch; 2.
DR   SUPFAM; SSF117281; SSF117281; 1.
PE   2: Evidence at transcript level;
KW   Kelch repeat; Reference proteome; Repeat; Ubl conjugation pathway.
FT   CHAIN           1..411
FT                   /note="Kelch domain-containing protein 10"
FT                   /id="PRO_0000319439"
FT   REPEAT          72..133
FT                   /note="Kelch 1"
FT   REPEAT          135..186
FT                   /note="Kelch 2"
FT   REPEAT          187..239
FT                   /note="Kelch 3"
FT   REPEAT          240..288
FT                   /note="Kelch 4"
FT   REPEAT          296..342
FT                   /note="Kelch 5"
FT   REPEAT          345..388
FT                   /note="Kelch 6"
SQ   SEQUENCE   411 AA;  46759 MW;  85C95934B6C0A32F CRC64;
     MAAEAGGGEP LVKFVKLSGR AAGSKKKVRW FPVRRLFTHS CPSLRIPSRF LREGRRSPPA
     RSGHRCVADN TNLYVFGGYN PDYDESGGPE NEDYPLFREL WRYHFATGMW HQMGTDGHMP
     RELASMSLVL HGHNLLVFGG TGIPFGESNG NDVYVCNVRY KRWSKLNCRG KKPNRIYGQA
     MAIIHGFLYV FGGTTGYIYS TDLHRLDLST REWIQLRPNN PPCDLPEERY RHEIAHDGQR
     IYVLGGGTSW TAYSLEKIHA YNFETNTWED IPTKPHGNLG FPAARRCHSC VQIKNEVFIC
     GGYNGLVILG DLWKLNLQTF QWTKLPALMP EPAYFHCAAV TPAGCMYIHG GVVNIQQNKR
     TGSLFKIWLT VPSLLELCWE NLLKYFPQLC QLPTHQLLQL GLSQELIERL K