ID   KLD10_XENTR             Reviewed;         411 AA.
AC   Q28DE7;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 2.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Kelch domain-containing protein 10 {ECO:0000305};
GN   Name=klhdc10 {ECO:0000250|UniProtKB:Q6PID8};
GN   ORFNames=TEgg142i20.1 {ECO:0000303|Ref.1};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Substrate-recognition component of a Cul2-RING (CRL2) E3
CC       ubiquitin-protein ligase complex of the DesCEND (destruction via C-end
CC       degrons) pathway, which recognizes a C-degron located at the extreme C
CC       terminus of target proteins, leading to their ubiquitination and
CC       degradation. The C-degron recognized by the DesCEND pathway is usually
CC       a motif of less than ten residues and can be present in full-length
CC       proteins, truncated proteins or proteolytically cleaved forms. The
CC       CRL2(KLHDC10) complex specifically recognizes proteins with a proline-
CC       glycine (Pro-Gly) at the C-terminus, leading to their ubiquitination
CC       and degradation. Participates in the oxidative stress-induced cell
CC       death through MAP3K5 activation. {ECO:0000250|UniProtKB:Q6PID8}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000250|UniProtKB:Q6PID8}.
CC   -!- SUBUNIT: Component of a CRL2 E3 ubiquitin-protein ligase complex, also
CC       named ECS (Elongin BC-CUL2/5-SOCS-box protein) complex, composed of
CC       CUL2, Elongin BC (ELOB and ELOC), RBX1 and substrate-specific adapter
CC       KLHDC10. {ECO:0000250|UniProtKB:Q6PID8}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAJ81314.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; CR855555; CAJ81314.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001016816.1; NM_001016816.2.
DR   AlphaFoldDB; Q28DE7; -.
DR   SMR; Q28DE7; -.
DR   STRING; 8364.ENSXETP00000035576; -.
DR   PaxDb; Q28DE7; -.
DR   Ensembl; ENSXETT00000035576; ENSXETP00000035576; ENSXETG00000016301.
DR   GeneID; 549570; -.
DR   KEGG; xtr:549570; -.
DR   CTD; 23008; -.
DR   Xenbase; XB-GENE-1014477; klhdc10.
DR   eggNOG; KOG0379; Eukaryota.
DR   HOGENOM; CLU_030914_0_0_1; -.
DR   InParanoid; Q28DE7; -.
DR   OrthoDB; 564212at2759; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000016301; Expressed in 4-cell stage embryo and 14 other tissues.
DR   GO; GO:0032874; P:positive regulation of stress-activated MAPK cascade; IBA:GO_Central.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   Gene3D; 2.120.10.80; -; 2.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   Pfam; PF01344; Kelch_1; 1.
DR   SMART; SM00612; Kelch; 2.
DR   SUPFAM; SSF117281; SSF117281; 1.
PE   2: Evidence at transcript level;
KW   Kelch repeat; Reference proteome; Repeat; Ubl conjugation pathway.
FT   CHAIN           1..411
FT                   /note="Kelch domain-containing protein 10"
FT                   /id="PRO_0000319440"
FT   REPEAT          72..133
FT                   /note="Kelch 1"
FT   REPEAT          135..186
FT                   /note="Kelch 2"
FT   REPEAT          187..239
FT                   /note="Kelch 3"
FT   REPEAT          240..288
FT                   /note="Kelch 4"
FT   REPEAT          296..342
FT                   /note="Kelch 5"
FT   REPEAT          345..388
FT                   /note="Kelch 6"
SQ   SEQUENCE   411 AA;  46737 MW;  58DBD5444CFA6322 CRC64;
     MAAEAGGGEP LVKFVKLSGR AAGSKKKVRW FPVRRLFTHS CPSLRIPSRF LREGRRSPPA
     RSGHRCVADN TNLYVFGGYN PDYDESGGPE NEDYPLFREL WRYHFATGMW HQMGTDGHMP
     RELASMSLVL HGHNLLVFGG TGIPFGESNG NDVYVCNVKY KRWSKLNCRG KKPNRIYGQA
     MAIIHGFLYV FGGTTGYIYS TDLHRLDLST REWIQLKPNN PPCDLPEERY RHEIAHDGQR
     IYVLGGGTSW TAYSLEKIHA YNFETNTWED IPTKPYGNLG FPAARRCHSC VQIKNEVFIC
     GGYNGLVILG DLWKLDLQTF QWTKLPALMP EPAYFHCAAV TPAGCMYIHG GVVNIQQNKR
     TGSLFKIWLV VPSLLELCWE NLLKYFPHLC QLPTHQLLQL GLSQELIERL K