KLD7A_MOUSE
ID KLD7A_MOUSE Reviewed; 773 AA.
AC A2APT9; Q80SV4; Q8C706;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 26-MAY-2009, sequence version 3.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Kelch domain-containing protein 7A;
GN Name=Klhdc7a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 14-759.
RC STRAIN=C57BL/6J; TISSUE=Kidney;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 358-773.
RC STRAIN=FVB/N; TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-361, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-89 AND SER-361, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Kidney, Liver, and Pancreas;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC35129.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC35129.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AL844480; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK052747; BAC35129.1; ALT_SEQ; mRNA.
DR EMBL; BC043462; AAH43462.1; -; mRNA.
DR EMBL; BC043672; AAH43672.1; -; mRNA.
DR CCDS; CCDS38935.1; -.
DR RefSeq; NP_775603.2; NM_173427.2.
DR AlphaFoldDB; A2APT9; -.
DR SMR; A2APT9; -.
DR STRING; 10090.ENSMUSP00000100648; -.
DR GlyGen; A2APT9; 2 sites.
DR iPTMnet; A2APT9; -.
DR PhosphoSitePlus; A2APT9; -.
DR jPOST; A2APT9; -.
DR MaxQB; A2APT9; -.
DR PaxDb; A2APT9; -.
DR PRIDE; A2APT9; -.
DR ProteomicsDB; 263448; -.
DR Antibodypedia; 64774; 5 antibodies from 5 providers.
DR Ensembl; ENSMUST00000105031; ENSMUSP00000100648; ENSMUSG00000078234.
DR GeneID; 242721; -.
DR KEGG; mmu:242721; -.
DR UCSC; uc008vmt.1; mouse.
DR CTD; 127707; -.
DR MGI; MGI:2444612; Klhdc7a.
DR VEuPathDB; HostDB:ENSMUSG00000078234; -.
DR eggNOG; KOG1072; Eukaryota.
DR GeneTree; ENSGT00940000162724; -.
DR HOGENOM; CLU_020313_1_0_1; -.
DR InParanoid; A2APT9; -.
DR OMA; EQRWWAG; -.
DR OrthoDB; 594274at2759; -.
DR PhylomeDB; A2APT9; -.
DR TreeFam; TF328485; -.
DR BioGRID-ORCS; 242721; 0 hits in 71 CRISPR screens.
DR ChiTaRS; Klhdc7a; mouse.
DR PRO; PR:A2APT9; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; A2APT9; protein.
DR Bgee; ENSMUSG00000078234; Expressed in lumbar subsegment of spinal cord and 66 other tissues.
DR Genevisible; A2APT9; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.120.10.80; -; 1.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR Pfam; PF01344; Kelch_1; 2.
DR SMART; SM00612; Kelch; 2.
DR SUPFAM; SSF117281; SSF117281; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Kelch repeat; Membrane; Phosphoprotein; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix.
FT CHAIN 1..773
FT /note="Kelch domain-containing protein 7A"
FT /id="PRO_0000285086"
FT TRANSMEM 23..40
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REPEAT 323..370
FT /note="Kelch 1"
FT REPEAT 488..534
FT /note="Kelch 2"
FT REPEAT 537..585
FT /note="Kelch 3"
FT REPEAT 586..628
FT /note="Kelch 4"
FT REPEAT 631..673
FT /note="Kelch 5"
FT REGION 64..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 114..207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 296..355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 89
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 361
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
FT CARBOHYD 61
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 256
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 14
FT /note="H -> I (in Ref. 2; BAC35129)"
FT /evidence="ECO:0000305"
FT CONFLICT 513
FT /note="A -> V (in Ref. 2; BAC35129)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 773 AA; 83590 MW; 200329BF358AB065 CRC64;
MLPTGEGAEG QDWHLDMQLP SKVVLSAAAL LLVTAAYKLY KSRPAPVGQA GRNNKDHKAE
NETEALGQLA FQEAPPGTLP RGRRRRKASK GAGTSLDYSL VDPEDPCILD ISRSEEATRK
GSDESQGRQC PDSQQVPPPC GGQEAGTDVR GKPNPPHLPH SGCEPTSSSG RLIPGVGGSC
VGDKLSPWPD SRPPEETGSG DLEAPNGWTD LTLVNGDMNQ SWIFTHMTGV SRGEAGVLQA
AADMGLATQQ QEGATNASHT FSSVARIRME ENIIQKAEGP GLKGRVYDYF VESTSKADSR
PVPCPAALAD APSPGPGPEP LVTGAASRDE AANTAGGGAS EAASPQPVAS PSAPGFSRKV
SLLQIAENPE LQLQPEGFRM PLPAHLDQRA QLSSACSHGE PHVQLVAGTN FFHIPLTPAS
ALDVRLDLGN CYEMLTLAKR QGLETLKEAA YKVLSDNYLQ VLRSPDIYGG LSGAERELIL
QRRFRGHKRL VVADMCPQDD SGRLCCYDNV QDAWHPLAQL PPEAMSRGCA LCTLFNYLFV
VSGCQEPGGQ PSNRVFCYNP LTAIWSEVCP LNQARPHCRL VALEGHLYAI GGECLNTVER
YDPRLDRWTF APPLPNDTFA LAHTATVCAN EIFVTGGSLR YLLLRFSTQE QRWWAGPTGG
SKDRTAEMVA VNGFLYRFDL NRSLGISVYR CSASTRLWYE CATYRLPYPD AFQCAVVDDH
IYCVGRRRML CFLADHISPR FVSKELKGFP SARGTLLPAV LTLPVPDVPQ TPV
