ID   KLD7A_PONAB             Reviewed;         768 AA.
AC   Q5R866; Q5R7Y6; Q5RCK4;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   26-MAY-2009, sequence version 4.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Kelch domain-containing protein 7A;
DE   Flags: Fragment;
GN   Name=KLHDC7A;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAH90503.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=CAH92044.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=CAH92124.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=CAH92124.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; CR858266; CAH90503.1; ALT_INIT; mRNA.
DR   EMBL; CR859888; CAH92044.1; ALT_INIT; mRNA.
DR   EMBL; CR859972; CAH92124.1; ALT_SEQ; mRNA.
DR   RefSeq; NP_001125264.1; NM_001131792.1.
DR   AlphaFoldDB; Q5R866; -.
DR   SMR; Q5R866; -.
DR   STRING; 9601.ENSPPYP00000002092; -.
DR   PRIDE; Q5R866; -.
DR   GeneID; 100172161; -.
DR   KEGG; pon:100172161; -.
DR   CTD; 127707; -.
DR   eggNOG; KOG1072; Eukaryota.
DR   InParanoid; Q5R866; -.
DR   OrthoDB; 594274at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.120.10.80; -; 1.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   Pfam; PF01344; Kelch_1; 2.
DR   SMART; SM00612; Kelch; 2.
DR   SUPFAM; SSF117281; SSF117281; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Kelch repeat; Membrane; Phosphoprotein; Reference proteome;
KW   Repeat; Transmembrane; Transmembrane helix.
FT   CHAIN           <1..768
FT                   /note="Kelch domain-containing protein 7A"
FT                   /id="PRO_0000285087"
FT   TRANSMEM        12..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REPEAT          319..365
FT                   /note="Kelch 1"
FT   REPEAT          483..529
FT                   /note="Kelch 2"
FT   REPEAT          532..580
FT                   /note="Kelch 3"
FT   REPEAT          581..623
FT                   /note="Kelch 4"
FT   REPEAT          626..668
FT                   /note="Kelch 5"
FT   REGION          35..210
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          304..352
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          371..395
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        119..141
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         77
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:A2APT9"
FT   MOD_RES         356
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q5VTJ3"
FT   CARBOHYD        248
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        121
FT                   /note="S -> G (in Ref. 1; CAH92044/CAH92124)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        133
FT                   /note="G -> S (in Ref. 1; CAH92044/CAH92124)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        141
FT                   /note="S -> G (in Ref. 1; CAH92044/CAH92124)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        144
FT                   /note="P -> S (in Ref. 1; CAH90503)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        173
FT                   /note="G -> S (in Ref. 1; CAH90503)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        176
FT                   /note="L -> P (in Ref. 1; CAH92044/CAH92124)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        567
FT                   /note="N -> S (in Ref. 1; CAH92044)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        656
FT                   /note="S -> I (in Ref. 1; CAH92044)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        761
FT                   /note="P -> L (in Ref. 1; CAH92044/CAH92124)"
FT                   /evidence="ECO:0000305"
FT   NON_TER         1
SQ   SEQUENCE   768 AA;  82947 MW;  E9AA3FD0B39845FD CRC64;
     DWHLDMQLTG KVVLSAAALL LVTVAYRLYK SRPAPAQRWG GNAQAEAKEE AQGSGQPAVQ
     EASPGVLLTG PRRRRSSKGA EAPQGCSCEN PRGPYVLVTG ATSTDRKSQR KGSGEERGGQ
     SSDSEQVPPC CRGQETRTAV SGNPDPPHLP RLGSEPNSSP AGLIAAADGS CAGGELSPPQ
     DSKPPEHPGL GQLEPPHCHH PAPLQGSSDM NQSWVFTRVI GVNREEAGAL EAASDVGLTL
     HQQEGAPNAS YTFSSIARVR MEENFIQKVE GVEPRLKGKV YDYYVESTSQ AIFQGRLAPR
     TAALTEVPSP RPPPRSLGTG AASGGQAGDT KGAAERAASP QPGPSPSTRG FSRKESLLQI
     AENPELQLQP DGFWLPAPPC PDPGALPGSG RSSQEPHVQL VAGTNFFHIP LTSASAPQVH
     LDLGNCYEVL TLAKRQNLEA LKEAAYKVMS ENYLQVLRSP DIYGCLSGAE RELILQRRLQ
     GRQYLVVADV SPKEDSGGLC CYDDELDVWR PLARLPPEAV SRGCAICSLF NYLFVVSGCQ
     GPGHQPSSRV FCYNPLTGIW SEVCPLNQAR PHCRLVALDG HLYAIGGECL NSVERYDPRL
     DRWDFAPPLP NDTFALAHTA TACAKEIFVT GGSLRFLLFR FSAQEQRWWA GPAGGSKDRT
     AEMVAVNGFL YRFDLNRSLG IAVYRCSAST RLWYECATYR TPYPDAFQCA VVDNLIYCVG
     RRSTLCFLAD SVSPRFVPKE LRSFPAPQGT LLPTVLTLPT PDLPQTRV