KLD8A_MOUSE
ID KLD8A_MOUSE Reviewed; 350 AA.
AC Q91XA8;
DT 21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Kelch domain-containing protein 8A;
GN Name=Klhdc8a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Retina, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Salivary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
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DR EMBL; AK044318; BAC31864.1; -; mRNA.
DR EMBL; AK080356; BAC37888.1; -; mRNA.
DR EMBL; BC011135; AAH11135.1; -; mRNA.
DR CCDS; CCDS35706.1; -.
DR RefSeq; NP_659059.1; NM_144810.5.
DR RefSeq; XP_006529417.1; XM_006529354.3.
DR AlphaFoldDB; Q91XA8; -.
DR SMR; Q91XA8; -.
DR BioGRID; 229425; 5.
DR STRING; 10090.ENSMUSP00000038297; -.
DR iPTMnet; Q91XA8; -.
DR PhosphoSitePlus; Q91XA8; -.
DR MaxQB; Q91XA8; -.
DR PaxDb; Q91XA8; -.
DR PRIDE; Q91XA8; -.
DR ProteomicsDB; 264944; -.
DR Antibodypedia; 20678; 122 antibodies from 22 providers.
DR DNASU; 213417; -.
DR Ensembl; ENSMUST00000046071; ENSMUSP00000038297; ENSMUSG00000042115.
DR GeneID; 213417; -.
DR KEGG; mmu:213417; -.
DR UCSC; uc007con.1; mouse.
DR CTD; 55220; -.
DR MGI; MGI:2442630; Klhdc8a.
DR VEuPathDB; HostDB:ENSMUSG00000042115; -.
DR eggNOG; KOG1072; Eukaryota.
DR GeneTree; ENSGT00940000160742; -.
DR HOGENOM; CLU_046864_0_0_1; -.
DR InParanoid; Q91XA8; -.
DR OMA; KWEVLPA; -.
DR OrthoDB; 1562595at2759; -.
DR PhylomeDB; Q91XA8; -.
DR BioGRID-ORCS; 213417; 4 hits in 73 CRISPR screens.
DR PRO; PR:Q91XA8; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q91XA8; protein.
DR Bgee; ENSMUSG00000042115; Expressed in adrenal gland and 135 other tissues.
DR Genevisible; Q91XA8; MM.
DR Gene3D; 2.120.10.80; -; 2.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR Pfam; PF01344; Kelch_1; 3.
DR SMART; SM00612; Kelch; 5.
DR SUPFAM; SSF117281; SSF117281; 2.
PE 2: Evidence at transcript level;
KW Kelch repeat; Reference proteome; Repeat.
FT CHAIN 1..350
FT /note="Kelch domain-containing protein 8A"
FT /id="PRO_0000229002"
FT REPEAT 1..31
FT /note="Kelch 1"
FT REPEAT 32..79
FT /note="Kelch 2"
FT REPEAT 81..127
FT /note="Kelch 3"
FT REPEAT 128..175
FT /note="Kelch 4"
FT REPEAT 176..222
FT /note="Kelch 5"
FT REPEAT 224..278
FT /note="Kelch 6"
FT REPEAT 279..326
FT /note="Kelch 7"
SQ SEQUENCE 350 AA; 38817 MW; 92F1BC7C9870C261 CRC64;
MEVPNVKDFQ WKRLAPLPSR RVYCSLLETG GQVYAIGGCD DNGVPMDCFE VYSPEADQWT
SLPSLPTARA GVAITALGKR IMVIGGVGTN QLPVKVVEMY NIDEGKWKKR SVLREAAMGI
SVTAKDYRVY AAGGMGLDLR PHNYLQHYDM LKDMWVSLAP MPTPRYAATS FLRGSKIYVL
GGRQSKYAVN AFEVFDIESR SWTKFPNIPC KRAFSSFVTL DNHLYSLGGL RQGRLYRQPK
FLRTMDVFDM EQGGWLKMER SFFLKKRRAD FVAGGLSGRV IVAGGLGNQP TVLETAEAFH
PEKNKWEALP PMPTPRCACS SIVFKNCLLA VGGVSQGLSD AVEALFVSDS
