ID   KLD8B_BOVIN             Reviewed;         354 AA.
AC   Q5E9V5; Q0V8C3;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Kelch domain-containing protein 8B;
GN   Name=KLHDC8B;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
CC   -!- FUNCTION: Involved in pinching off the separated nuclei at the cleavage
CC       furrow and in cytokinesis. Required for mitotic integrity and
CC       maintenance of chromosomal stability. Protects cells against mitotic
CC       errors, centrosomal amplification, micronucleus formation and
CC       aneuploidy. Plays a key role of midbody function involving abscission
CC       of the daughter cells during cytokinesis and appropriate chromosomal
CC       and nuclear segregation into the daughter cells.
CC       {ECO:0000250|UniProtKB:Q8IXV7}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8IXV7}. Midbody
CC       {ECO:0000250|UniProtKB:Q8IXV7}. Note=In mitotic cells, concentrates in
CC       the midbody of the cytoplasmic bridge linking daughter cells as they
CC       are about to separate during cytokinesis.
CC       {ECO:0000250|UniProtKB:Q8IXV7}.
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DR   EMBL; BT020815; AAX08832.1; -; mRNA.
DR   EMBL; BT026296; ABG81452.1; -; mRNA.
DR   RefSeq; NP_001030447.2; NM_001035370.2.
DR   RefSeq; XP_015315070.1; XM_015459584.1.
DR   RefSeq; XP_015315071.1; XM_015459585.1.
DR   AlphaFoldDB; Q5E9V5; -.
DR   SMR; Q5E9V5; -.
DR   STRING; 9913.ENSBTAP00000001298; -.
DR   PaxDb; Q5E9V5; -.
DR   PRIDE; Q5E9V5; -.
DR   GeneID; 527321; -.
DR   KEGG; bta:527321; -.
DR   CTD; 200942; -.
DR   eggNOG; KOG1072; Eukaryota.
DR   HOGENOM; CLU_046864_0_0_1; -.
DR   InParanoid; Q5E9V5; -.
DR   OrthoDB; 933937at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0110070; C:cellularization cleavage furrow; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0045171; C:intercellular bridge; ISS:UniProtKB.
DR   GO; GO:0030496; C:midbody; ISS:UniProtKB.
DR   GO; GO:1902410; P:mitotic cytokinetic process; ISS:UniProtKB.
DR   GO; GO:0140014; P:mitotic nuclear division; ISS:UniProtKB.
DR   GO; GO:0098813; P:nuclear chromosome segregation; ISS:UniProtKB.
DR   Gene3D; 2.120.10.80; -; 2.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   Pfam; PF01344; Kelch_1; 3.
DR   SMART; SM00612; Kelch; 6.
DR   SUPFAM; SSF117281; SSF117281; 2.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Cytoplasm; Kelch repeat; Reference proteome;
KW   Repeat.
FT   CHAIN           1..354
FT                   /note="Kelch domain-containing protein 8B"
FT                   /id="PRO_0000119130"
FT   REPEAT          1..31
FT                   /note="Kelch 1"
FT   REPEAT          32..79
FT                   /note="Kelch 2"
FT   REPEAT          81..127
FT                   /note="Kelch 3"
FT   REPEAT          128..175
FT                   /note="Kelch 4"
FT   REPEAT          176..222
FT                   /note="Kelch 5"
FT   REPEAT          224..281
FT                   /note="Kelch 6"
FT   REPEAT          282..329
FT                   /note="Kelch 7"
FT   REPEAT          331..354
FT                   /note="Kelch 8"
FT   CONFLICT        303
FT                   /note="G -> S (in Ref. 1; ABG81452)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   354 AA;  37540 MW;  3463E46845A5C458 CRC64;
     MATGGGRAFA WQVFPPMPTC RVYGTVAFQD GHLLVLGGCG RAGLPLDTAE TLDMASHTWV
     ALAPLPTARA GAAAVVLGKQ VLVVGGVDEG QSPVAAVEAF LADEGRWERR ATLPQAAMGV
     ATVERDGMVY ALGGMGPDTA PQAQVRVYEP RRDCWLSLPS MPTPCYGAST FLHGNKIYVL
     GGRQGKLPVT AFEAFDLEAR TWTRHPSLPS RRAFAGCAMA EGSVFSLGGL QQPGPHNFYS
     RPHFVNTVEM FDLEHGSWTK LPRSLRMRDK RADFVVGSLG DHVVAIGGLG NQPCPLGSVE
     GFGLARRRWE ALPAMPTARC SCSSLQAGPR LFAIGGVAQG PSQAVEALCL RDGV