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ARAE3_ORYSJ
ID   ARAE3_ORYSJ             Reviewed;         406 AA.
AC   Q8H0B2; Q0J884; Q7EZR9;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=Probable UDP-arabinose 4-epimerase 3;
DE            EC=5.1.3.5;
DE   AltName: Full=OsUEL-3;
DE   AltName: Full=UDP-D-xylose 4-epimerase 3;
DE   AltName: Full=UDP-galactose 4-epimerase-like protein 3;
GN   Name=UEL-3; OrderedLocusNames=Os08g0129700, LOC_Os08g03570;
GN   ORFNames=P0582D05.120;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Nipponbare; TISSUE=Seed;
RA   Suzuki K., Kitamura S.;
RT   "Cloning of UDP-glucose 4-epimerase-like genes in Oryza sativa.";
RL   Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=UDP-beta-L-arabinopyranose = UDP-alpha-D-xylose;
CC         Xref=Rhea:RHEA:11320, ChEBI:CHEBI:57632, ChEBI:CHEBI:61457;
CC         EC=5.1.3.5;
CC   -!- COFACTOR:
CC       Name=NAD(+); Xref=ChEBI:CHEBI:57540; Evidence={ECO:0000250};
CC   -!- PATHWAY: Nucleotide-sugar biosynthesis; UDP-L-arabinose biosynthesis;
CC       UDP-L-arabinose from UDP-alpha-D-xylose: step 1/1.
CC   -!- PATHWAY: Cell wall biogenesis; cell wall polysaccharide biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane
CC       {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAD09640.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AP004591; BAD09640.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AP008214; BAF22831.1; -; Genomic_DNA.
DR   EMBL; AP014964; BAT03688.1; -; Genomic_DNA.
DR   EMBL; AK065715; BAG89638.1; -; mRNA.
DR   EMBL; AB099292; BAC53786.1; -; mRNA.
DR   RefSeq; XP_015649744.1; XM_015794258.1.
DR   AlphaFoldDB; Q8H0B2; -.
DR   SMR; Q8H0B2; -.
DR   STRING; 4530.OS08T0129700-01; -.
DR   PaxDb; Q8H0B2; -.
DR   PRIDE; Q8H0B2; -.
DR   EnsemblPlants; Os08t0129700-01; Os08t0129700-01; Os08g0129700.
DR   EnsemblPlants; Os08t0129700-02; Os08t0129700-02; Os08g0129700.
DR   GeneID; 4344584; -.
DR   Gramene; Os08t0129700-01; Os08t0129700-01; Os08g0129700.
DR   Gramene; Os08t0129700-02; Os08t0129700-02; Os08g0129700.
DR   KEGG; osa:4344584; -.
DR   eggNOG; KOG1371; Eukaryota.
DR   HOGENOM; CLU_007383_1_10_1; -.
DR   InParanoid; Q8H0B2; -.
DR   OMA; QMVESAW; -.
DR   OrthoDB; 662484at2759; -.
DR   PlantReactome; R-OSA-1119428; GDP-D-rhamnose biosynthesis.
DR   PlantReactome; R-OSA-1119574; UDP-L-arabinose biosynthesis and transport.
DR   PlantReactome; R-OSA-1119620; GDP-L-fucose biosynthesis I (from GDP-D-mannose).
DR   UniPathway; UPA00797; UER00772.
DR   UniPathway; UPA00963; -.
DR   Proteomes; UP000000763; Chromosome 8.
DR   Proteomes; UP000059680; Chromosome 8.
DR   Genevisible; Q8H0B2; OS.
DR   GO; GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0050373; F:UDP-arabinose 4-epimerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0003978; F:UDP-glucose 4-epimerase activity; IEA:InterPro.
DR   GO; GO:0045227; P:capsule polysaccharide biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006012; P:galactose metabolic process; IEA:InterPro.
DR   GO; GO:0033358; P:UDP-L-arabinose biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd05247; UDP_G4E_1_SDR_e; 1.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR005886; UDP_G4E.
DR   Pfam; PF16363; GDP_Man_Dehyd; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR01179; galE; 1.
PE   2: Evidence at transcript level;
KW   Carbohydrate metabolism; Golgi apparatus; Isomerase; Membrane; NAD;
KW   Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix.
FT   CHAIN           1..406
FT                   /note="Probable UDP-arabinose 4-epimerase 3"
FT                   /id="PRO_0000183235"
FT   TOPO_DOM        1..26
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        27..44
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        45..406
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        213
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
FT   BINDING         65..96
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   406 AA;  44827 MW;  C6C5B8392507C3E6 CRC64;
     MIPLNRRASQ TRGGMEYFDA RRKPHNVGKV IAALVLTTLC IFILKQSPGF GGSSVFSRHE
     PGVTHVLVTG GAGYIGSHAS LRLLKDNYRV TIVDNLSRGN MGAVKVLQEL FPQPGRLQFI
     YADLGDQKTV NKIFAENAFD AVMHFAAVAY VGESTLEPLR YYHNITSNTL LILEAMASHG
     VKTLIYSSTC ATYGEPEKMP IVETTRQLPI NPYGKAKKMA EDIILDFTKG RKDMAVMILR
     YFNVIGSDPE GRLGEAPRPE LREHGRISGA CFDAALGIIP GLKVKGTDYP TTDGTCIRDY
     IDVTDLVDAH VKALNKAEPS KVGIYNVGTG RGRSVKEFVD ACKKATGVNI KIEYLSRRPG
     DYAEVYSDPT KINTELNWTA QYTDLKESLS VAWRWQKSHP RGYGSN
 
 
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