KLD8B_PONAB
ID KLD8B_PONAB Reviewed; 354 AA.
AC Q5RCW7;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=Kelch domain-containing protein 8B;
GN Name=KLHDC8B;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Heart;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in pinching off the separated nuclei at the cleavage
CC furrow and in cytokinesis. Required for mitotic integrity and
CC maintenance of chromosomal stability. Protects cells against mitotic
CC errors, centrosomal amplification, micronucleus formation and
CC aneuploidy. Plays a key role of midbody function involving abscission
CC of the daughter cells during cytokinesis and appropriate chromosomal
CC and nuclear segregation into the daughter cells.
CC {ECO:0000250|UniProtKB:Q8IXV7}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8IXV7}. Midbody
CC {ECO:0000250|UniProtKB:Q8IXV7}. Note=In mitotic cells, concentrates in
CC the midbody of the cytoplasmic bridge linking daughter cells as they
CC are about to separate during cytokinesis.
CC {ECO:0000250|UniProtKB:Q8IXV7}.
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DR EMBL; CR858151; CAH90390.1; -; mRNA.
DR RefSeq; NP_001125190.1; NM_001131718.1.
DR AlphaFoldDB; Q5RCW7; -.
DR SMR; Q5RCW7; -.
DR STRING; 9601.ENSPPYP00000015526; -.
DR Ensembl; ENSPPYT00000016143; ENSPPYP00000015526; ENSPPYG00000013878.
DR GeneID; 100172081; -.
DR KEGG; pon:100172081; -.
DR CTD; 200942; -.
DR eggNOG; KOG1072; Eukaryota.
DR GeneTree; ENSGT00940000160815; -.
DR HOGENOM; CLU_046864_0_0_1; -.
DR InParanoid; Q5RCW7; -.
DR OrthoDB; 933937at2759; -.
DR Proteomes; UP000001595; Chromosome 3.
DR GO; GO:0110070; C:cellularization cleavage furrow; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0045171; C:intercellular bridge; ISS:UniProtKB.
DR GO; GO:0030496; C:midbody; ISS:UniProtKB.
DR GO; GO:1902410; P:mitotic cytokinetic process; ISS:UniProtKB.
DR GO; GO:0140014; P:mitotic nuclear division; ISS:UniProtKB.
DR GO; GO:0098813; P:nuclear chromosome segregation; ISS:UniProtKB.
DR Gene3D; 2.120.10.80; -; 3.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR Pfam; PF01344; Kelch_1; 4.
DR SMART; SM00612; Kelch; 6.
DR SUPFAM; SSF117281; SSF117281; 2.
PE 2: Evidence at transcript level;
KW Cell cycle; Cell division; Cytoplasm; Kelch repeat; Reference proteome;
KW Repeat.
FT CHAIN 1..354
FT /note="Kelch domain-containing protein 8B"
FT /id="PRO_0000119133"
FT REPEAT 1..31
FT /note="Kelch 1"
FT REPEAT 32..79
FT /note="Kelch 2"
FT REPEAT 81..127
FT /note="Kelch 3"
FT REPEAT 128..175
FT /note="Kelch 4"
FT REPEAT 176..222
FT /note="Kelch 5"
FT REPEAT 224..281
FT /note="Kelch 6"
FT REPEAT 282..329
FT /note="Kelch 7"
FT REPEAT 331..354
FT /note="Kelch 8"
SQ SEQUENCE 354 AA; 37748 MW; 34CEBEDCE4D1632B CRC64;
MSAGGGRAFA WQVFPPMPTC RVYGTVAHQD EHLLVLGGCG RAGLPLDTAE TLDMASHTWL
ALAPLPTARA GAAAVVLGKQ VLVVGGVDEV QSPVAAVEAF LMDEGRWERR ATLPQAAMGV
ATVERDGMVY ALGGMGPDTA PQAQVRVYEP RRDCWLSLPS MPTPCYGAST FLHGNKIYVL
GGRQGKLPVT AFEAFDLEAR TWTRHPSLPS RRAFAGCAMA EGSVFSLGGL QQPGPHNFYS
RPHFVNTVEM FDLEHGSWTK LPRSLRMRDK RADFVVGSLG GHIVAIGGLG NQPCPLGSVE
SFSLARRRWE ALPAMPTARC SCSSLQAGPR LFVIGGVAQG PSQAVEALCL RDGV
