ID   KLDC1_ARTBC             Reviewed;         668 AA.
AC   D4AYG1;
DT   09-DEC-2015, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 1.
DT   25-MAY-2022, entry version 39.
DE   RecName: Full=Kelch repeat-containing protein ARB_01230;
DE   Flags: Precursor;
GN   ORFNames=ARB_01230;
OS   Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton
OS   mentagrophytes).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX   NCBI_TaxID=663331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4681 / CBS 112371;
RX   PubMed=21247460; DOI=10.1186/gb-2011-12-1-r7;
RA   Burmester A., Shelest E., Gloeckner G., Heddergott C., Schindler S.,
RA   Staib P., Heidel A., Felder M., Petzold A., Szafranski K., Feuermann M.,
RA   Pedruzzi I., Priebe S., Groth M., Winkler R., Li W., Kniemeyer O.,
RA   Schroeckh V., Hertweck C., Hube B., White T.C., Platzer M., Guthke R.,
RA   Heitman J., Woestemeyer J., Zipfel P.F., Monod M., Brakhage A.A.;
RT   "Comparative and functional genomics provide insights into the
RT   pathogenicity of dermatophytic fungi.";
RL   Genome Biol. 12:R7.1-R7.16(2011).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RX   PubMed=21919205; DOI=10.1002/pmic.201100234;
RA   Sriranganadane D., Waridel P., Salamin K., Feuermann M., Mignon B.,
RA   Staib P., Neuhaus J.M., Quadroni M., Monod M.;
RT   "Identification of novel secreted proteases during extracellular
RT   proteolysis by dermatophytes at acidic pH.";
RL   Proteomics 11:4422-4433(2011).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC       protein {ECO:0000255}. Secreted {ECO:0000269|PubMed:21919205}.
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DR   EMBL; ABSU01000018; EFE31977.1; -; Genomic_DNA.
DR   RefSeq; XP_003012617.1; XM_003012571.1.
DR   AlphaFoldDB; D4AYG1; -.
DR   SMR; D4AYG1; -.
DR   STRING; 63400.XP_003012617.1; -.
DR   EnsemblFungi; EFE31977; EFE31977; ARB_01230.
DR   GeneID; 9522694; -.
DR   KEGG; abe:ARB_01230; -.
DR   eggNOG; KOG0379; Eukaryota.
DR   HOGENOM; CLU_012508_0_0_1; -.
DR   OMA; QMNVIDV; -.
DR   Proteomes; UP000008866; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.120.10.80; -; 2.
DR   InterPro; IPR011043; Gal_Oxase/kelch_b-propeller.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   SUPFAM; SSF50965; SSF50965; 1.
PE   1: Evidence at protein level;
KW   Glycoprotein; Kelch repeat; Membrane; Reference proteome; Repeat; Secreted;
KW   Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..32
FT                   /evidence="ECO:0000255"
FT   CHAIN           33..668
FT                   /note="Kelch repeat-containing protein ARB_01230"
FT                   /id="PRO_0000434930"
FT   TOPO_DOM        33..522
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        523..543
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        544..668
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   REPEAT          62..108
FT                   /note="Kelch 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          125..176
FT                   /note="Kelch 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          283..331
FT                   /note="Kelch 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          340..395
FT                   /note="Kelch 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          396..445
FT                   /note="Kelch 5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          463..509
FT                   /note="Kelch 6"
FT                   /evidence="ECO:0000255"
FT   REGION          611..642
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        60
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        251
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        291
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   668 AA;  71480 MW;  9AFF97A28BDB8A97 CRC64;
     MEVGRFASKS ASMTYLLLVL LVGFILPQQG QHAHARTLAR RDNSPTDICK RWSQQTAIVN
     GTLYIYGGRS TTDASQKDNT WNDNFLTLDL KSSWGISAPK LTGLPRGDNG PPPVSNGYLW
     NSFSSLFLYG GEFSDNPATE PVDFSLWEYS IPSSSWIEHK SPKTSSGENS AEANIPVQRS
     AEGAGINVPD LGRGWYFGGH LDGYTTKGWS QSIPRVYLKS MIEYTFPGHT NNGVKINTDD
     KRAGPEGVWR NITEGGLQDS AGFTERADGV LVYIPGFGKE GIILGLAGGT NATFTQMNVI
     DVFDIASSKW YKQATSGKTP KIRVNPCAVA ASAADGSSTQ VYLFGGQNLI PYGEQIQYND
     MWILSIPSFT WIEAKTDGQS VPPARAGHTC NIWNSQIVVT GGYVGQDLSC DSPGIYVFDA
     SELTWKNQYT ALEGGNDLNQ QASQTRDSSG LGGSYGYRVP KVVQSVIGGD ETGKATQTVP
     AVAPTDGPLA TGQPLTYTVL PTAGSGPHAG SPGSGSDGPN IAAIVAGVIA GCLGVLAIYL
     GFVTWLYRRR LAIYKSHLAA TQRSSIGSYG DKISSFPPRY SDHMSSSGLG TTGSTGNLTV
     TTARMSWISG DNQRHNHTRS SSGGNFDHLA QPERPSTSSS VEDLLAGQEP TFLGVMLNPR
     QTLRVINQ