ID   KLDC4_MOUSE             Reviewed;         584 AA.
AC   Q921I2; Q8CIK0;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 2.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=Kelch domain-containing protein 4;
GN   Name=Klhdc4;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
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DR   EMBL; BC012312; AAH12312.1; -; mRNA.
DR   EMBL; BC023738; AAH23738.2; -; mRNA.
DR   CCDS; CCDS22729.1; -.
DR   AlphaFoldDB; Q921I2; -.
DR   SMR; Q921I2; -.
DR   STRING; 10090.ENSMUSP00000043439; -.
DR   iPTMnet; Q921I2; -.
DR   PhosphoSitePlus; Q921I2; -.
DR   EPD; Q921I2; -.
DR   MaxQB; Q921I2; -.
DR   PaxDb; Q921I2; -.
DR   PeptideAtlas; Q921I2; -.
DR   PRIDE; Q921I2; -.
DR   ProteomicsDB; 263449; -.
DR   MGI; MGI:2384569; Klhdc4.
DR   eggNOG; KOG1230; Eukaryota.
DR   InParanoid; Q921I2; -.
DR   PhylomeDB; Q921I2; -.
DR   ChiTaRS; Klhdc4; mouse.
DR   PRO; PR:Q921I2; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; Q921I2; protein.
DR   Gene3D; 2.120.10.80; -; 2.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR011498; Kelch_2.
DR   Pfam; PF07646; Kelch_2; 1.
DR   SUPFAM; SSF117281; SSF117281; 2.
PE   2: Evidence at transcript level;
KW   Kelch repeat; Phosphoprotein; Reference proteome; Repeat.
FT   CHAIN           1..584
FT                   /note="Kelch domain-containing protein 4"
FT                   /id="PRO_0000228999"
FT   REPEAT          77..129
FT                   /note="Kelch 1"
FT   REPEAT          133..187
FT                   /note="Kelch 2"
FT   REPEAT          188..238
FT                   /note="Kelch 3"
FT   REPEAT          243..289
FT                   /note="Kelch 4"
FT   REPEAT          308..361
FT                   /note="Kelch 5"
FT   REPEAT          443..494
FT                   /note="Kelch 6"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          50..69
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          348..381
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          405..433
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          482..533
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        11..33
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        416..431
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        488..515
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        516..533
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         418
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TBB5"
FT   CONFLICT        509
FT                   /note="K -> E (in Ref. 1; AAH12312)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   584 AA;  64860 MW;  711604D6A599E775 CRC64;
     MGKKGKKEKK GRGAEKTAAK MEKKVSKRSR KEEEDLEALI AHFQTLDAKK TQVTETPCPP
     PSPRLNASLS AHPEKDELIL FGGEYFNGQK TFMYNELYIY SIRKDTWTKV DIPGPPPRRC
     AHQAVVVPQG GGQLWVFGGE FASPDGEQFY HYKDLWVLHL ATKTWEQIRS TGGPSGRSGH
     RMVAWKRQLI LFGGFHESAR DYIYYSDVYT FSLDTFQWSK LSPSGAGPTP RSGCLMAVTP
     QGSIAIYGGY SKQRVKKDVD KGTQHSDMFL LKPAEGGEGK WAWTRINPSG VKPTARSGFS
     VAVAPNHQIL VFGGVCDEEE EESLEGSFFS DLYIYDAAKS RWFAAQLKGP KSEKKKRRRG
     KAEDPEGTTE QETGGSSAPE PLEVIKEVVS EDGTVVTIKQ VLTPSGLGVQ PSPKADDSAS
     EASSTGQEPC PRSNAMLAVK HGLLYVYGGM FEAGDRQVTL SDLYCLDLHK MEEWKTLVEM
     DPKSQEWLEE SDSEEDSSSD EESEDGEDKD QEDSAEEGAD PQHPEVARGE QFEEYLSRTE
     QHWLKLARSH VGPEAKEKKV LKVAQAMAKS CFDDAVQDIA QARH