ID   KLDC4_PONAB             Reviewed;         522 AA.
AC   Q5R8W1;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Kelch domain-containing protein 4;
GN   Name=KLHDC4;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CR859637; CAH91799.1; -; mRNA.
DR   RefSeq; NP_001126046.1; NM_001132574.1.
DR   AlphaFoldDB; Q5R8W1; -.
DR   SMR; Q5R8W1; -.
DR   STRING; 9601.ENSPPYP00000008610; -.
DR   GeneID; 100172995; -.
DR   KEGG; pon:100172995; -.
DR   CTD; 54758; -.
DR   eggNOG; KOG1230; Eukaryota.
DR   InParanoid; Q5R8W1; -.
DR   OrthoDB; 836122at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   Gene3D; 2.120.10.80; -; 2.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR011498; Kelch_2.
DR   Pfam; PF07646; Kelch_2; 2.
DR   SUPFAM; SSF117281; SSF117281; 2.
PE   2: Evidence at transcript level;
KW   Kelch repeat; Phosphoprotein; Reference proteome; Repeat.
FT   CHAIN           1..522
FT                   /note="Kelch domain-containing protein 4"
FT                   /id="PRO_0000286397"
FT   REPEAT          77..129
FT                   /note="Kelch 1"
FT   REPEAT          133..187
FT                   /note="Kelch 2"
FT   REPEAT          188..241
FT                   /note="Kelch 3"
FT   REPEAT          243..289
FT                   /note="Kelch 4"
FT   REPEAT          308..361
FT                   /note="Kelch 5"
FT   REPEAT          443..494
FT                   /note="Kelch 6"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          346..378
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          402..432
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          481..522
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        11..33
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        483..522
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         413
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TBB5"
FT   MOD_RES         418
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TBB5"
SQ   SEQUENCE   522 AA;  58231 MW;  DBDB810B6C5E002A CRC64;
     MGKKGKKEKK GRGAEKTAAK MEKKVSKRSR KEEEDLEALI AHFQTLDAKR TQTVEAPCPP
     PSPRLNASLS VHPEKDELIL FGGEYFNGQK TFLYNELYVY NIRKDTWTKV DIPSPPPRRC
     AHQAVVVPQG GGQLWVFGGE FASPNGEQFY HYKDLWVLHL ATKTWEQVKS TGSPSGRSGH
     RMVAWKRQLI LFGGFHESTR DYIYYNDVYT FNLDTFTWSK LSPSGTGPTP RSGCQMSVTP
     QGGIIIYGGY SKQRVKKDVD RGTRHSDMFL LKPEDGREDK WVWTRMNPSG VKPTPRSGFS
     AAMALNHQTL FFGGVCDEEE EESLAGEFFN DLYFYDATRN RWFEGQLKGP KSEKKKRRRG
     RKEESEGGSK LACGGAGTQG PVQVVKEVVA EDGTVVTIKQ VLAAPGSAGQ PRSEDEDSPE
     EAGSSAPGPC PRSNAMLAVK HGVLYVYGGM FEAGDRQVTL SDLHCLDLHR MEAWKALVEM
     DPETQEWLEE TDSEEDSEEV EGAEGGDEDE DEDSREESGA ED