KLDC9_MOUSE
ID KLDC9_MOUSE Reviewed; 350 AA.
AC Q3USL1; Q8BVR4;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Kelch domain-containing protein 9;
GN Name=Klhdc9;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Corpora quadrigemina, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBUNIT: Interacts with CCNA1. {ECO:0000250}.
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DR EMBL; AK076812; BAC36492.1; -; mRNA.
DR EMBL; AK140290; BAE24320.1; -; mRNA.
DR CCDS; CCDS35776.1; -.
DR RefSeq; NP_001028211.1; NM_001033039.2.
DR AlphaFoldDB; Q3USL1; -.
DR SMR; Q3USL1; -.
DR STRING; 10090.ENSMUSP00000056212; -.
DR iPTMnet; Q3USL1; -.
DR PhosphoSitePlus; Q3USL1; -.
DR SwissPalm; Q3USL1; -.
DR PaxDb; Q3USL1; -.
DR PRIDE; Q3USL1; -.
DR ProteomicsDB; 263450; -.
DR Antibodypedia; 34288; 77 antibodies from 15 providers.
DR Ensembl; ENSMUST00000061878; ENSMUSP00000056212; ENSMUSG00000045259.
DR GeneID; 68874; -.
DR KEGG; mmu:68874; -.
DR UCSC; uc007dod.1; mouse.
DR CTD; 126823; -.
DR MGI; MGI:1916124; Klhdc9.
DR VEuPathDB; HostDB:ENSMUSG00000045259; -.
DR eggNOG; KOG0379; Eukaryota.
DR GeneTree; ENSGT00390000011582; -.
DR HOGENOM; CLU_068365_0_0_1; -.
DR InParanoid; Q3USL1; -.
DR OMA; APHLMEQ; -.
DR OrthoDB; 933937at2759; -.
DR PhylomeDB; Q3USL1; -.
DR TreeFam; TF337916; -.
DR BioGRID-ORCS; 68874; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Klhdc9; mouse.
DR PRO; PR:Q3USL1; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q3USL1; protein.
DR Bgee; ENSMUSG00000045259; Expressed in spermatocyte and 49 other tissues.
DR GO; GO:0030332; F:cyclin binding; ISO:MGI.
DR Gene3D; 2.120.10.80; -; 2.
DR InterPro; IPR011043; Gal_Oxase/kelch_b-propeller.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR042941; KLDC9.
DR PANTHER; PTHR47196; PTHR47196; 1.
DR SUPFAM; SSF50965; SSF50965; 1.
PE 1: Evidence at protein level;
KW Kelch repeat; Reference proteome; Repeat.
FT CHAIN 1..350
FT /note="Kelch domain-containing protein 9"
FT /id="PRO_0000300465"
FT REPEAT 39..89
FT /note="Kelch 1"
FT REPEAT 91..137
FT /note="Kelch 2"
FT REPEAT 325..350
FT /note="Kelch 3"
SQ SEQUENCE 350 AA; 38185 MW; 2A9EC8D6FD4CE394 CRC64;
MAGVQTLGRA RGSTWTWRPV ARDVLLARAF HSCTELEGRF YLVGGLLEGG ARVPSNDTVI
FDPAVGQAVR LVARGSPLRS HHDAALVGGR WLCVVGGWDG SRRLSTVAAL DTEREVWEAW
AANPGNCPPA GLSSHTCTRL SDGELRVSGR EGGTHTQRRY GSIYTLKLDH RTRTYCYKEE
GCHTTSRSGH CAALLPTAGP HPGHQLLLFG GCNSVGPEVA GQWSPGKIKE EQPVAPHLRE
QLARLVSSGQ GLQQGPQSLR HHSCSVVGPF AVLFGGETLT RARDTICNDL YIYDTRKSPP
LWFHFPSTDR GLKRVGHRTC LWNDQLYLVG GFGEDGRTAS PQVCILEFFI
