KLF11_HUMAN
ID KLF11_HUMAN Reviewed; 512 AA.
AC O14901; B4DZE7; Q9EPF4;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 2.
DT 03-AUG-2022, entry version 195.
DE RecName: Full=Krueppel-like factor 11;
DE AltName: Full=Transforming growth factor-beta-inducible early growth response protein 2;
DE Short=TGFB-inducible early growth response protein 2;
DE Short=TIEG-2;
GN Name=KLF11; Synonyms=FKLF, TIEG2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, AND
RP INDUCTION.
RC TISSUE=Pancreas;
RX PubMed=9748269; DOI=10.1074/jbc.273.40.25929;
RA Cook T., Gebelein B., Mesa K., Mladek A., Urrutia R.;
RT "Molecular cloning and characterization of TIEG2 reveals a new subfamily of
RT transforming growth factor-beta-inducible Sp1-like zinc finger-encoding
RT genes involved in the regulation of cell growth.";
RL J. Biol. Chem. 273:25929-25936(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, AND TISSUE SPECIFICITY.
RC TISSUE=Erythroid cell;
RX PubMed=10207080; DOI=10.1128/mcb.19.5.3571;
RA Asano H., Li X.S., Stamatoyannopoulos G.;
RT "FKLF, a novel Kruppel-like factor that activates human embryonic and fetal
RT beta-like globin genes.";
RL Mol. Cell. Biol. 19:3571-3579(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Hepatoma;
RX PubMed=11087666; DOI=10.1006/geno.2000.6362;
RA Scohy S., Gabant P., Van Reeth T., Hertveldt V., Dreze P.-L.,
RA Van Vooren P., Riviere M., Szpirer J., Szpirer C.;
RT "Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF
RT transcription factor family.";
RL Genomics 70:93-101(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP FUNCTION.
RX PubMed=16131492; DOI=10.1074/jbc.m504402200;
RA Blau C.A., Barbas C.F., Bomhoff A.L., Neades R., Yan J., Navas P.A.,
RA Peterson K.R.;
RT "{gamma}-Globin gene expression in chemical inducer of dimerization (CID)-
RT dependent multipotential cells established from human {beta}-globin locus
RT yeast artificial chromosome ({beta}-YAC) transgenic mice.";
RL J. Biol. Chem. 280:36642-36647(2005).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-124, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [10]
RP VARIANTS MODY7 MET-220 AND SER-347, VARIANT ARG-62, CHARACTERIZATION OF
RP VARIANTS MODY7 MET-220 AND SER-347, CHARACTERIZATION OF VARIANT ARG-62, AND
RP INTERACTION WITH SIN3A.
RX PubMed=15774581; DOI=10.1073/pnas.0409177102;
RA Neve B., Fernandez-Zapico M.E., Ashkenazi-Katalan V., Dina C., Hamid Y.H.,
RA Joly E., Vaillant E., Benmezroua Y., Durand E., Bakaher N., Delannoy V.,
RA Vaxillaire M., Cook T., Dallinga-Thie G.M., Jansen H., Charles M.-A.,
RA Clement K., Galan P., Hercberg S., Helbecque N., Charpentier G.,
RA Prentki M., Hansen T., Pedersen O., Urrutia R., Melloul D., Froguel P.;
RT "Role of transcription factor KLF11 and its diabetes-associated gene
RT variants in pancreatic beta cell function.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:4807-4812(2005).
CC -!- FUNCTION: Transcription factor (PubMed:9748269, PubMed:10207080).
CC Activates the epsilon- and gamma-globin gene promoters and, to a much
CC lower degree, the beta-globin gene and represses promoters containing
CC SP1-like binding inhibiting cell growth (PubMed:9748269,
CC PubMed:10207080, PubMed:16131492). Represses transcription of SMAD7
CC which enhances TGF-beta signaling (By similarity). Induces apoptosis
CC (By similarity). {ECO:0000250|UniProtKB:Q8K1S5,
CC ECO:0000269|PubMed:10207080, ECO:0000269|PubMed:16131492}.
CC -!- SUBUNIT: Interacts with SIN3A. {ECO:0000269|PubMed:15774581}.
CC -!- INTERACTION:
CC O14901; Q96MA6: AK8; NbExp=3; IntAct=EBI-948266, EBI-8466265;
CC O14901; Q99996-3: AKAP9; NbExp=3; IntAct=EBI-948266, EBI-11022349;
CC O14901; Q9NP70: AMBN; NbExp=3; IntAct=EBI-948266, EBI-11893530;
CC O14901; Q6ZTN6-2: ANKRD13D; NbExp=3; IntAct=EBI-948266, EBI-25840993;
CC O14901; Q6LES2: ANXA4; NbExp=3; IntAct=EBI-948266, EBI-10250835;
CC O14901; P13928: ANXA8; NbExp=3; IntAct=EBI-948266, EBI-2556915;
CC O14901; P05067: APP; NbExp=3; IntAct=EBI-948266, EBI-77613;
CC O14901; Q92624: APPBP2; NbExp=3; IntAct=EBI-948266, EBI-743771;
CC O14901; O94778: AQP8; NbExp=3; IntAct=EBI-948266, EBI-19124986;
CC O14901; Q52LW3-2: ARHGAP29; NbExp=3; IntAct=EBI-948266, EBI-22012297;
CC O14901; Q9Y2Y0: ARL2BP; NbExp=3; IntAct=EBI-948266, EBI-3449344;
CC O14901; Q8WXK3: ASB13; NbExp=3; IntAct=EBI-948266, EBI-707573;
CC O14901; Q9Y575-3: ASB3; NbExp=3; IntAct=EBI-948266, EBI-14199987;
CC O14901; Q96DX5-3: ASB9; NbExp=3; IntAct=EBI-948266, EBI-25843552;
CC O14901; Q96FT7-4: ASIC4; NbExp=3; IntAct=EBI-948266, EBI-9089489;
CC O14901; Q9UII2: ATP5IF1; NbExp=3; IntAct=EBI-948266, EBI-718459;
CC O14901; P15313: ATP6V1B1; NbExp=3; IntAct=EBI-948266, EBI-2891281;
CC O14901; Q8TBE0: BAHD1; NbExp=3; IntAct=EBI-948266, EBI-742750;
CC O14901; O75934: BCAS2; NbExp=3; IntAct=EBI-948266, EBI-1050106;
CC O14901; P54687-4: BCAT1; NbExp=3; IntAct=EBI-948266, EBI-25834445;
CC O14901; P06276: BCHE; NbExp=3; IntAct=EBI-948266, EBI-7936069;
CC O14901; Q14457: BECN1; NbExp=3; IntAct=EBI-948266, EBI-949378;
CC O14901; Q96LC9: BMF; NbExp=3; IntAct=EBI-948266, EBI-3919268;
CC O14901; Q969J3: BORCS5; NbExp=3; IntAct=EBI-948266, EBI-747707;
CC O14901; Q6PJG6: BRAT1; NbExp=3; IntAct=EBI-948266, EBI-10826195;
CC O14901; Q8WUW1: BRK1; NbExp=3; IntAct=EBI-948266, EBI-2837444;
CC O14901; Q9H0W9-3: C11orf54; NbExp=3; IntAct=EBI-948266, EBI-12108466;
CC O14901; Q8IVU9: CABCOCO1; NbExp=3; IntAct=EBI-948266, EBI-21771960;
CC O14901; O95503: CBX6; NbExp=3; IntAct=EBI-948266, EBI-3951758;
CC O14901; A0A1B0GWI1: CCDC196; NbExp=3; IntAct=EBI-948266, EBI-10181422;
CC O14901; Q9NNX6-10: CD209; NbExp=3; IntAct=EBI-948266, EBI-12300031;
CC O14901; Q9HCU0: CD248; NbExp=3; IntAct=EBI-948266, EBI-9680942;
CC O14901; Q9UJX2: CDC23; NbExp=3; IntAct=EBI-948266, EBI-396137;
CC O14901; Q7Z7K6: CENPV; NbExp=3; IntAct=EBI-948266, EBI-1210604;
CC O14901; Q53EZ4: CEP55; NbExp=3; IntAct=EBI-948266, EBI-747776;
CC O14901; Q8NHQ1: CEP70; NbExp=3; IntAct=EBI-948266, EBI-739624;
CC O14901; Q8WUX9: CHMP7; NbExp=3; IntAct=EBI-948266, EBI-749253;
CC O14901; Q6PJW8-3: CNST; NbExp=3; IntAct=EBI-948266, EBI-25836090;
CC O14901; Q96JB2-2: COG3; NbExp=3; IntAct=EBI-948266, EBI-9091495;
CC O14901; Q96MW5: COG8; NbExp=3; IntAct=EBI-948266, EBI-720875;
CC O14901; Q8NE08: COL25A1; NbExp=3; IntAct=EBI-948266, EBI-25836642;
CC O14901; P13073: COX4I1; NbExp=3; IntAct=EBI-948266, EBI-1056574;
CC O14901; P24310: COX7A1; NbExp=3; IntAct=EBI-948266, EBI-25876196;
CC O14901; Q9BSW2: CRACR2A; NbExp=3; IntAct=EBI-948266, EBI-739773;
CC O14901; Q96SW2: CRBN; NbExp=3; IntAct=EBI-948266, EBI-2510250;
CC O14901; Q8IUI8: CRLF3; NbExp=3; IntAct=EBI-948266, EBI-2872414;
CC O14901; P53672: CRYBA2; NbExp=3; IntAct=EBI-948266, EBI-750444;
CC O14901; Q7L576: CYFIP1; NbExp=3; IntAct=EBI-948266, EBI-1048143;
CC O14901; Q9NUQ9: CYRIB; NbExp=3; IntAct=EBI-948266, EBI-1055930;
CC O14901; Q9UJU6: DBNL; NbExp=3; IntAct=EBI-948266, EBI-751783;
CC O14901; O75935-2: DCTN3; NbExp=3; IntAct=EBI-948266, EBI-12091947;
CC O14901; Q8WTU0: DDI1; NbExp=3; IntAct=EBI-948266, EBI-748248;
CC O14901; Q14154: DELE1; NbExp=3; IntAct=EBI-948266, EBI-2805660;
CC O14901; Q9UBP4: DKK3; NbExp=3; IntAct=EBI-948266, EBI-954409;
CC O14901; A0A024RCP2: DOM3Z; NbExp=3; IntAct=EBI-948266, EBI-25847826;
CC O14901; Q86TI2-2: DPP9; NbExp=3; IntAct=EBI-948266, EBI-21529239;
CC O14901; Q14117: DPYS; NbExp=3; IntAct=EBI-948266, EBI-12275416;
CC O14901; Q9BPU6: DPYSL5; NbExp=3; IntAct=EBI-948266, EBI-724653;
CC O14901; Q9H410: DSN1; NbExp=3; IntAct=EBI-948266, EBI-1001144;
CC O14901; A0AVK6: E2F8; NbExp=3; IntAct=EBI-948266, EBI-7779316;
CC O14901; H3BUJ7: E4F1; NbExp=3; IntAct=EBI-948266, EBI-10178160;
CC O14901; Q5JVL4: EFHC1; NbExp=3; IntAct=EBI-948266, EBI-743105;
CC O14901; O00303: EIF3F; NbExp=3; IntAct=EBI-948266, EBI-711990;
CC O14901; Q9UBQ5: EIF3K; NbExp=3; IntAct=EBI-948266, EBI-354344;
CC O14901; Q9Y262: EIF3L; NbExp=3; IntAct=EBI-948266, EBI-373519;
CC O14901; Q969X5: ERGIC1; NbExp=3; IntAct=EBI-948266, EBI-781527;
CC O14901; Q6NXG1: ESRP1; NbExp=3; IntAct=EBI-948266, EBI-10213520;
CC O14901; Q6NXG1-3: ESRP1; NbExp=3; IntAct=EBI-948266, EBI-21567429;
CC O14901; Q6P1L5: FAM117B; NbExp=3; IntAct=EBI-948266, EBI-3893327;
CC O14901; Q49AJ0-4: FAM135B; NbExp=3; IntAct=EBI-948266, EBI-25835236;
CC O14901; A1KXE4-2: FAM168B; NbExp=3; IntAct=EBI-948266, EBI-12193763;
CC O14901; O15287: FANCG; NbExp=3; IntAct=EBI-948266, EBI-81610;
CC O14901; Q8WVX9: FAR1; NbExp=3; IntAct=EBI-948266, EBI-1045879;
CC O14901; Q9NSA1: FGF21; NbExp=3; IntAct=EBI-948266, EBI-3909329;
CC O14901; Q5TD97: FHL5; NbExp=3; IntAct=EBI-948266, EBI-750641;
CC O14901; Q9BQS8-2: FYCO1; NbExp=3; IntAct=EBI-948266, EBI-25905795;
CC O14901; P06241-3: FYN; NbExp=3; IntAct=EBI-948266, EBI-10691738;
CC O14901; Q06547-2: GABPB1; NbExp=3; IntAct=EBI-948266, EBI-618189;
CC O14901; Q06547-3: GABPB1; NbExp=3; IntAct=EBI-948266, EBI-9088619;
CC O14901; F2Z2M7: GALNT10; NbExp=3; IntAct=EBI-948266, EBI-23893155;
CC O14901; P15976-2: GATA1; NbExp=3; IntAct=EBI-948266, EBI-9090198;
CC O14901; Q9BRX5: GINS3; NbExp=3; IntAct=EBI-948266, EBI-2857315;
CC O14901; Q9NS71: GKN1; NbExp=3; IntAct=EBI-948266, EBI-3933251;
CC O14901; Q96IJ6: GMPPA; NbExp=3; IntAct=EBI-948266, EBI-750953;
CC O14901; P51674: GPM6A; NbExp=3; IntAct=EBI-948266, EBI-7187133;
CC O14901; Q9H9Y4: GPN2; NbExp=3; IntAct=EBI-948266, EBI-11603368;
CC O14901; Q93077: H2AC6; NbExp=3; IntAct=EBI-948266, EBI-725259;
CC O14901; Q6NXT2: H3-5; NbExp=3; IntAct=EBI-948266, EBI-2868501;
CC O14901; Q96CS2: HAUS1; NbExp=3; IntAct=EBI-948266, EBI-2514791;
CC O14901; Q68CZ6: HAUS3; NbExp=3; IntAct=EBI-948266, EBI-2558217;
CC O14901; Q99871: HAUS7; NbExp=3; IntAct=EBI-948266, EBI-395719;
CC O14901; P42858: HTT; NbExp=7; IntAct=EBI-948266, EBI-466029;
CC O14901; Q8NDH6-2: ICA1L; NbExp=3; IntAct=EBI-948266, EBI-12141931;
CC O14901; P80217-2: IFI35; NbExp=3; IntAct=EBI-948266, EBI-12823003;
CC O14901; Q8IY31-2: IFT20; NbExp=3; IntAct=EBI-948266, EBI-11742277;
CC O14901; Q8IY31-3: IFT20; NbExp=3; IntAct=EBI-948266, EBI-9091197;
CC O14901; P08833: IGFBP1; NbExp=3; IntAct=EBI-948266, EBI-13646303;
CC O14901; P22692: IGFBP4; NbExp=3; IntAct=EBI-948266, EBI-2831948;
CC O14901; Q14005-2: IL16; NbExp=3; IntAct=EBI-948266, EBI-17178971;
CC O14901; Q0VD86: INCA1; NbExp=3; IntAct=EBI-948266, EBI-6509505;
CC O14901; Q86VI3: IQGAP3; NbExp=3; IntAct=EBI-948266, EBI-1237354;
CC O14901; Q8NA54: IQUB; NbExp=3; IntAct=EBI-948266, EBI-10220600;
CC O14901; Q13352: ITGB3BP; NbExp=6; IntAct=EBI-948266, EBI-712105;
CC O14901; Q96I82: KAZALD1; NbExp=3; IntAct=EBI-948266, EBI-25904181;
CC O14901; A1A512: KIAA0355; NbExp=3; IntAct=EBI-948266, EBI-25844799;
CC O14901; Q6ZU52: KIAA0408; NbExp=3; IntAct=EBI-948266, EBI-739493;
CC O14901; Q8IV33: KIAA0825; NbExp=3; IntAct=EBI-948266, EBI-17702098;
CC O14901; Q9BVG8-5: KIFC3; NbExp=3; IntAct=EBI-948266, EBI-14069005;
CC O14901; Q6P597: KLC3; NbExp=3; IntAct=EBI-948266, EBI-1643885;
CC O14901; Q9UIH9: KLF15; NbExp=3; IntAct=EBI-948266, EBI-2796400;
CC O14901; P57682: KLF3; NbExp=3; IntAct=EBI-948266, EBI-8472267;
CC O14901; Q13887: KLF5; NbExp=3; IntAct=EBI-948266, EBI-2696013;
CC O14901; Q9Y2M5: KLHL20; NbExp=3; IntAct=EBI-948266, EBI-714379;
CC O14901; Q9UH77: KLHL3; NbExp=3; IntAct=EBI-948266, EBI-8524663;
CC O14901; Q96NJ5: KLHL32; NbExp=3; IntAct=EBI-948266, EBI-6426390;
CC O14901; Q8N1A0: KRT222; NbExp=3; IntAct=EBI-948266, EBI-8473062;
CC O14901; Q14525: KRT33B; NbExp=3; IntAct=EBI-948266, EBI-1049638;
CC O14901; Q15012: LAPTM4A; NbExp=3; IntAct=EBI-948266, EBI-723416;
CC O14901; Q92615: LARP4B; NbExp=3; IntAct=EBI-948266, EBI-1052558;
CC O14901; Q6DKI2: LGALS9C; NbExp=3; IntAct=EBI-948266, EBI-9088829;
CC O14901; Q96JB6: LOXL4; NbExp=3; IntAct=EBI-948266, EBI-749562;
CC O14901; Q9BV99: LRRC61; NbExp=3; IntAct=EBI-948266, EBI-2350424;
CC O14901; Q96LR2: LURAP1; NbExp=3; IntAct=EBI-948266, EBI-741355;
CC O14901; Q9BRK4: LZTS2; NbExp=3; IntAct=EBI-948266, EBI-741037;
CC O14901; Q9UDY8-2: MALT1; NbExp=3; IntAct=EBI-948266, EBI-12056869;
CC O14901; P27338: MAOB; NbExp=3; IntAct=EBI-948266, EBI-3911344;
CC O14901; Q13503: MED21; NbExp=3; IntAct=EBI-948266, EBI-394678;
CC O14901; Q14696: MESD; NbExp=3; IntAct=EBI-948266, EBI-6165891;
CC O14901; Q8N6F8: METTL27; NbExp=3; IntAct=EBI-948266, EBI-8487781;
CC O14901; Q9NYP9: MIS18A; NbExp=3; IntAct=EBI-948266, EBI-1104552;
CC O14901; Q9HBH9-2: MKNK2; NbExp=3; IntAct=EBI-948266, EBI-14141314;
CC O14901; Q9Y605: MRFAP1; NbExp=3; IntAct=EBI-948266, EBI-995714;
CC O14901; Q96HT8: MRFAP1L1; NbExp=3; IntAct=EBI-948266, EBI-748896;
CC O14901; P02795: MT2A; NbExp=3; IntAct=EBI-948266, EBI-996616;
CC O14901; Q8WY64: MYLIP; NbExp=3; IntAct=EBI-948266, EBI-6952711;
CC O14901; I6L9F6: NEFL; NbExp=3; IntAct=EBI-948266, EBI-10178578;
CC O14901; Q8IXH7: NELFCD; NbExp=3; IntAct=EBI-948266, EBI-536725;
CC O14901; Q13562: NEUROD1; NbExp=3; IntAct=EBI-948266, EBI-3908303;
CC O14901; Q13952-2: NFYC; NbExp=3; IntAct=EBI-948266, EBI-11956831;
CC O14901; Q6PHZ7: NR2C2; NbExp=3; IntAct=EBI-948266, EBI-2802743;
CC O14901; Q9NXX6-2: NSMCE4A; NbExp=3; IntAct=EBI-948266, EBI-25905546;
CC O14901; Q7Z3B4: NUP54; NbExp=3; IntAct=EBI-948266, EBI-741048;
CC O14901; A5D8V7: ODAD3; NbExp=3; IntAct=EBI-948266, EBI-8466445;
CC O14901; O43482: OIP5; NbExp=3; IntAct=EBI-948266, EBI-536879;
CC O14901; Q9BZF3-6: OSBPL6; NbExp=3; IntAct=EBI-948266, EBI-10698423;
CC O14901; Q96FW1: OTUB1; NbExp=3; IntAct=EBI-948266, EBI-1058491;
CC O14901; Q6GQQ9-2: OTUD7B; NbExp=3; IntAct=EBI-948266, EBI-25830200;
CC O14901; Q9NUU6: OTULINL; NbExp=3; IntAct=EBI-948266, EBI-6916492;
CC O14901; Q9ULW8: PADI3; NbExp=3; IntAct=EBI-948266, EBI-10488185;
CC O14901; Q9BPZ3: PAIP2; NbExp=3; IntAct=EBI-948266, EBI-2957445;
CC O14901; Q9BR81: PCDHGC3; NbExp=3; IntAct=EBI-948266, EBI-22012354;
CC O14901; P22061-2: PCMT1; NbExp=3; IntAct=EBI-948266, EBI-12386584;
CC O14901; O15534: PER1; NbExp=3; IntAct=EBI-948266, EBI-2557276;
CC O14901; Q99471: PFDN5; NbExp=3; IntAct=EBI-948266, EBI-357275;
CC O14901; Q8IXK0-5: PHC2; NbExp=3; IntAct=EBI-948266, EBI-11527347;
CC O14901; Q9BUL5: PHF23; NbExp=3; IntAct=EBI-948266, EBI-722852;
CC O14901; P57054: PIGP; NbExp=3; IntAct=EBI-948266, EBI-17630288;
CC O14901; P55347: PKNOX1; NbExp=3; IntAct=EBI-948266, EBI-1373569;
CC O14901; Q6P1J6-2: PLB1; NbExp=3; IntAct=EBI-948266, EBI-10694821;
CC O14901; Q58EX7-2: PLEKHG4; NbExp=3; IntAct=EBI-948266, EBI-21503705;
CC O14901; Q6P1K2: PMF1; NbExp=3; IntAct=EBI-948266, EBI-713832;
CC O14901; Q8N490-3: PNKD; NbExp=3; IntAct=EBI-948266, EBI-25879276;
CC O14901; Q6ZMI0-5: PPP1R21; NbExp=3; IntAct=EBI-948266, EBI-25835994;
CC O14901; P30154-2: PPP2R1B; NbExp=3; IntAct=EBI-948266, EBI-11058011;
CC O14901; A0A0C4DFM3: PRUNE2; NbExp=3; IntAct=EBI-948266, EBI-25830870;
CC O14901; P35998: PSMC2; NbExp=3; IntAct=EBI-948266, EBI-359710;
CC O14901; Q96QF0-7: RAB3IP; NbExp=3; IntAct=EBI-948266, EBI-11984839;
CC O14901; P47736: RAP1GAP; NbExp=3; IntAct=EBI-948266, EBI-722307;
CC O14901; Q15293: RCN1; NbExp=3; IntAct=EBI-948266, EBI-948278;
CC O14901; Q96EN9: REX1BD; NbExp=3; IntAct=EBI-948266, EBI-745810;
CC O14901; P47804-3: RGR; NbExp=3; IntAct=EBI-948266, EBI-25834767;
CC O14901; Q9UGC6: RGS17; NbExp=3; IntAct=EBI-948266, EBI-3918154;
CC O14901; Q96EP0: RNF31; NbExp=3; IntAct=EBI-948266, EBI-948111;
CC O14901; Q15349: RPS6KA2; NbExp=3; IntAct=EBI-948266, EBI-1384149;
CC O14901; P51812: RPS6KA3; NbExp=3; IntAct=EBI-948266, EBI-1046616;
CC O14901; O75676-2: RPS6KA4; NbExp=3; IntAct=EBI-948266, EBI-21622593;
CC O14901; Q9BY12-3: SCAPER; NbExp=3; IntAct=EBI-948266, EBI-25837959;
CC O14901; Q96GM5: SMARCD1; NbExp=3; IntAct=EBI-948266, EBI-358489;
CC O14901; Q96H20: SNF8; NbExp=3; IntAct=EBI-948266, EBI-747719;
CC O14901; Q8N0X2-4: SPAG16; NbExp=3; IntAct=EBI-948266, EBI-11946259;
CC O14901; Q7Z6I5: SPATA12; NbExp=3; IntAct=EBI-948266, EBI-10696971;
CC O14901; Q8IXS7: SRGAP3; NbExp=3; IntAct=EBI-948266, EBI-18616594;
CC O14901; Q14765: STAT4; NbExp=3; IntAct=EBI-948266, EBI-1186538;
CC O14901; Q9NRP7: STK36; NbExp=3; IntAct=EBI-948266, EBI-863797;
CC O14901; O75558: STX11; NbExp=3; IntAct=EBI-948266, EBI-714135;
CC O14901; Q8N4C7: STX19; NbExp=3; IntAct=EBI-948266, EBI-8484990;
CC O14901; P61764: STXBP1; NbExp=3; IntAct=EBI-948266, EBI-960169;
CC O14901; A1L190: SYCE3; NbExp=3; IntAct=EBI-948266, EBI-10283466;
CC O14901; O75528: TADA3; NbExp=3; IntAct=EBI-948266, EBI-473249;
CC O14901; O60907-2: TBL1X; NbExp=3; IntAct=EBI-948266, EBI-15904933;
CC O14901; Q9BZK7: TBL1XR1; NbExp=3; IntAct=EBI-948266, EBI-765729;
CC O14901; Q3YBR2: TBRG1; NbExp=3; IntAct=EBI-948266, EBI-2800552;
CC O14901; O15273: TCAP; NbExp=3; IntAct=EBI-948266, EBI-954089;
CC O14901; Q8N4U5: TCP11L2; NbExp=3; IntAct=EBI-948266, EBI-11897462;
CC O14901; Q86WV5: TEN1; NbExp=3; IntAct=EBI-948266, EBI-2562799;
CC O14901; Q9BXU0: TEX12; NbExp=3; IntAct=EBI-948266, EBI-12090309;
CC O14901; Q8WTV1: THAP3; NbExp=3; IntAct=EBI-948266, EBI-17438286;
CC O14901; Q8WUU8: TMEM174; NbExp=3; IntAct=EBI-948266, EBI-10276729;
CC O14901; Q8IUR5-4: TMTC1; NbExp=3; IntAct=EBI-948266, EBI-9089156;
CC O14901; Q12888: TP53BP1; NbExp=3; IntAct=EBI-948266, EBI-396540;
CC O14901; Q86WT6-2: TRIM69; NbExp=3; IntAct=EBI-948266, EBI-11525489;
CC O14901; Q96A04: TSACC; NbExp=3; IntAct=EBI-948266, EBI-740411;
CC O14901; Q86WV8: TSC1; NbExp=3; IntAct=EBI-948266, EBI-12806590;
CC O14901; Q99598: TSNAX; NbExp=3; IntAct=EBI-948266, EBI-742638;
CC O14901; O60636: TSPAN2; NbExp=3; IntAct=EBI-948266, EBI-3914288;
CC O14901; Q6PF05: TTC23L; NbExp=3; IntAct=EBI-948266, EBI-8656864;
CC O14901; Q6PID6: TTC33; NbExp=3; IntAct=EBI-948266, EBI-2555404;
CC O14901; O14530: TXNDC9; NbExp=3; IntAct=EBI-948266, EBI-707554;
CC O14901; P49459: UBE2A; NbExp=3; IntAct=EBI-948266, EBI-2339348;
CC O14901; Q9H347: UBQLN3; NbExp=3; IntAct=EBI-948266, EBI-25832660;
CC O14901; Q8IYU4: UBQLNL; NbExp=3; IntAct=EBI-948266, EBI-12295223;
CC O14901; Q16851: UGP2; NbExp=3; IntAct=EBI-948266, EBI-743729;
CC O14901; Q9NYH9: UTP6; NbExp=3; IntAct=EBI-948266, EBI-749211;
CC O14901; P45880: VDAC2; NbExp=3; IntAct=EBI-948266, EBI-354022;
CC O14901; P08670: VIM; NbExp=3; IntAct=EBI-948266, EBI-353844;
CC O14901; Q9H270: VPS11; NbExp=3; IntAct=EBI-948266, EBI-373380;
CC O14901; Q8NEZ2: VPS37A; NbExp=3; IntAct=EBI-948266, EBI-2850578;
CC O14901; P58304: VSX2; NbExp=3; IntAct=EBI-948266, EBI-6427899;
CC O14901; Q9BRX9: WDR83; NbExp=3; IntAct=EBI-948266, EBI-7705033;
CC O14901; Q86U90: YRDC; NbExp=3; IntAct=EBI-948266, EBI-21659356;
CC O14901; O43829: ZBTB14; NbExp=3; IntAct=EBI-948266, EBI-10176632;
CC O14901; Q8IWT0-2: ZBTB8OS; NbExp=3; IntAct=EBI-948266, EBI-12956041;
CC O14901; Q9H4I2-2: ZHX3; NbExp=3; IntAct=EBI-948266, EBI-10693326;
CC O14901; Q96JL9-2: ZNF333; NbExp=3; IntAct=EBI-948266, EBI-25835852;
CC O14901; Q9UL40: ZNF346; NbExp=3; IntAct=EBI-948266, EBI-2462313;
CC O14901; Q96MN9-2: ZNF488; NbExp=3; IntAct=EBI-948266, EBI-25831733;
CC O14901; Q8NBB4-2: ZSCAN1; NbExp=3; IntAct=EBI-948266, EBI-12021938;
CC O14901; O95229: ZWINT; NbExp=3; IntAct=EBI-948266, EBI-1001132;
CC O14901; Q2QGD7: ZXDC; NbExp=3; IntAct=EBI-948266, EBI-1538838;
CC O14901; A0A384NQ31; NbExp=3; IntAct=EBI-948266, EBI-12903728;
CC O14901; B7Z3E8; NbExp=3; IntAct=EBI-948266, EBI-25831617;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9748269}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=O14901-1; Sequence=Displayed;
CC Name=2;
CC IsoId=O14901-2; Sequence=VSP_042695;
CC -!- TISSUE SPECIFICITY: Ubiquitous. Higher expression in erythroid cells.
CC {ECO:0000269|PubMed:10207080}.
CC -!- INDUCTION: By TGFB1. {ECO:0000269|PubMed:9748269}.
CC -!- DISEASE: Maturity-onset diabetes of the young 7 (MODY7) [MIM:610508]: A
CC form of diabetes that is characterized by an autosomal dominant mode of
CC inheritance, onset in childhood or early adulthood (usually before 25
CC years of age), a primary defect in insulin secretion and frequent
CC insulin-independence at the beginning of the disease.
CC {ECO:0000269|PubMed:15774581}. Note=The disease is caused by variants
CC affecting the gene represented in this entry.
CC -!- SIMILARITY: Belongs to the Sp1 C2H2-type zinc-finger protein family.
CC {ECO:0000305}.
CC -!- CAUTION: PubMed:11087666 sequence was originally thought to originate
CC from mouse. {ECO:0000305}.
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DR EMBL; AF028008; AAC61880.1; -; mRNA.
DR EMBL; AF272830; AAF75793.1; -; mRNA.
DR EMBL; AK302880; BAG64059.1; -; mRNA.
DR EMBL; AC104794; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471053; EAX00972.1; -; Genomic_DNA.
DR EMBL; BC063286; AAH63286.1; -; mRNA.
DR EMBL; BC069383; AAH69383.1; -; mRNA.
DR EMBL; BC074922; AAH74922.1; -; mRNA.
DR CCDS; CCDS1668.1; -. [O14901-1]
DR CCDS; CCDS54333.1; -. [O14901-2]
DR RefSeq; NP_001171187.1; NM_001177716.1. [O14901-2]
DR RefSeq; NP_001171189.1; NM_001177718.1. [O14901-2]
DR RefSeq; NP_003588.1; NM_003597.4. [O14901-1]
DR AlphaFoldDB; O14901; -.
DR SMR; O14901; -.
DR BioGRID; 114040; 21.
DR ELM; O14901; -.
DR IntAct; O14901; 238.
DR STRING; 9606.ENSP00000307023; -.
DR iPTMnet; O14901; -.
DR PhosphoSitePlus; O14901; -.
DR BioMuta; KLF11; -.
DR jPOST; O14901; -.
DR MassIVE; O14901; -.
DR MaxQB; O14901; -.
DR PaxDb; O14901; -.
DR PeptideAtlas; O14901; -.
DR PRIDE; O14901; -.
DR ProteomicsDB; 48287; -. [O14901-1]
DR ProteomicsDB; 48288; -. [O14901-2]
DR Antibodypedia; 12498; 367 antibodies from 32 providers.
DR DNASU; 8462; -.
DR Ensembl; ENST00000305883.6; ENSP00000307023.1; ENSG00000172059.11. [O14901-1]
DR Ensembl; ENST00000535335.1; ENSP00000442722.1; ENSG00000172059.11. [O14901-2]
DR Ensembl; ENST00000540845.5; ENSP00000444690.1; ENSG00000172059.11. [O14901-2]
DR GeneID; 8462; -.
DR KEGG; hsa:8462; -.
DR MANE-Select; ENST00000305883.6; ENSP00000307023.1; NM_003597.5; NP_003588.1.
DR UCSC; uc010yjc.2; human. [O14901-1]
DR CTD; 8462; -.
DR DisGeNET; 8462; -.
DR GeneCards; KLF11; -.
DR GeneReviews; KLF11; -.
DR HGNC; HGNC:11811; KLF11.
DR HPA; ENSG00000172059; Low tissue specificity.
DR MalaCards; KLF11; -.
DR MIM; 603301; gene.
DR MIM; 606391; phenotype.
DR MIM; 610508; phenotype.
DR neXtProt; NX_O14901; -.
DR OpenTargets; ENSG00000172059; -.
DR Orphanet; 552; MODY.
DR PharmGKB; PA36518; -.
DR VEuPathDB; HostDB:ENSG00000172059; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000155982; -.
DR HOGENOM; CLU_046370_0_0_1; -.
DR InParanoid; O14901; -.
DR OMA; CQMVPVT; -.
DR PhylomeDB; O14901; -.
DR TreeFam; TF315506; -.
DR PathwayCommons; O14901; -.
DR SignaLink; O14901; -.
DR SIGNOR; O14901; -.
DR BioGRID-ORCS; 8462; 18 hits in 1108 CRISPR screens.
DR ChiTaRS; KLF11; human.
DR GeneWiki; KLF11; -.
DR GenomeRNAi; 8462; -.
DR Pharos; O14901; Tbio.
DR PRO; PR:O14901; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; O14901; protein.
DR Bgee; ENSG00000172059; Expressed in secondary oocyte and 175 other tissues.
DR ExpressionAtlas; O14901; baseline and differential.
DR Genevisible; O14901; HS.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005925; C:focal adhesion; IDA:HPA.
DR GO; GO:0016604; C:nuclear body; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; TAS:ProtInc.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; TAS:ProtInc.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IDA:BHF-UCL.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IDA:BHF-UCL.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:1901653; P:cellular response to peptide; IEA:Ensembl.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IDA:BHF-UCL.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:BHF-UCL.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IDA:BHF-UCL.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0000083; P:regulation of transcription involved in G1/S transition of mitotic cell cycle; IDA:BHF-UCL.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 3.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE 1: Evidence at protein level;
KW Activator; Alternative splicing; Apoptosis; Diabetes mellitus;
KW Disease variant; DNA-binding; Metal-binding; Nucleus; Phosphoprotein;
KW Reference proteome; Repeat; Repressor; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..512
FT /note="Krueppel-like factor 11"
FT /id="PRO_0000047180"
FT ZN_FING 394..418
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 424..448
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 454..476
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 109..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 124
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 1..17
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_042695"
FT VARIANT 62
FT /note="Q -> R (high frequency in individuals with diabetes
FT mellitus type 2; increased repression activity; increased
FT binding to SIN3A; impairs activation of insulin promoter;
FT dbSNP:rs35927125)"
FT /evidence="ECO:0000269|PubMed:15774581"
FT /id="VAR_031522"
FT VARIANT 220
FT /note="T -> M (in MODY7; absent in one family member with
FT diabetes; increased repression activity; no alteration in
FT binding affinity to SIN3A; dbSNP:rs34336420)"
FT /evidence="ECO:0000269|PubMed:15774581"
FT /id="VAR_031523"
FT VARIANT 347
FT /note="A -> S (in MODY7; increased repression activity; no
FT alteration in binding affinity to SIN3A;
FT dbSNP:rs121912645)"
FT /evidence="ECO:0000269|PubMed:15774581"
FT /id="VAR_031524"
FT VARIANT 378
FT /note="S -> F (in dbSNP:rs35476458)"
FT /id="VAR_052717"
FT CONFLICT 125
FT /note="P -> S (in Ref. 3)"
FT /evidence="ECO:0000305"
FT CONFLICT 144..150
FT /note="VVARALS -> QWPDSD (in Ref. 3)"
FT /evidence="ECO:0000305"
FT CONFLICT 371
FT /note="P -> L (in Ref. 3)"
FT /evidence="ECO:0000305"
FT CONFLICT 415
FT /note="L -> V (in Ref. 3)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 512 AA; 55139 MW; A69863B5467FB068 CRC64;
MHTPDFAGPD DARAVDIMDI CESILERKRH DSERSTCSIL EQTDMEAVEA LVCMSSWGQR
SQKGDLLRIR PLTPVSDSGD VTTTVHMDAA TPELPKDFHS LSTLCITPPQ SPDLVEPSTR
TPVSPQVTDS KACTATDVLQ SSAVVARALS GGAERGLLGL EPVPSSPCRA KGTSVIRHTG
ESPAACFPTI QTPDCRLSDS REGEEQLLGH FETLQDTHLT DSLLSTNLVS CQPCLHKSGG
LLLTDKGQQA GWPGAVQTCS PKNYENDLPR KTTPLISVSV PAPPVLCQMI PVTGQSSMLP
AFLKPPPQLS VGTVRPILAQ AAPAPQPVFV GPAVPQGAVM LVLPQGALPP PAPCAANVMA
AGNTKLLPLA PAPVFITSSQ NCVPQVDFSR RRNYVCSFPG CRKTYFKSSH LKAHLRTHTG
EKPFNCSWDG CDKKFARSDE LSRHRRTHTG EKKFVCPVCD RRFMRSDHLT KHARRHMTTK
KIPGWQAEVG KLNRIASAES PGSPLVSMPA SA
