KLF14_HUMAN
ID KLF14_HUMAN Reviewed; 323 AA.
AC Q8TD94; A0A075B756; A4D1N0; Q19A42; Q19A43;
DT 16-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT 28-MAR-2018, sequence version 2.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Krueppel-like factor 14;
DE AltName: Full=Basic transcription element-binding protein 5;
DE Short=BTE-binding protein 5;
DE AltName: Full=Transcription factor BTEB5;
GN Name=KLF14; Synonyms=BTEB5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Kaczynski J.A., Urrutia R.A.;
RT "Identification of BTEB5, a new member of the BTEB subfamily of Sp1-like
RT proteins.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RA Parker-Katiraee L., Scherer S.W.;
RT "The centre for applied genomics genome annotation project.";
RL Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the Sp1 C2H2-type zinc-finger protein family.
CC {ECO:0000305}.
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DR EMBL; AF490374; AAM08349.1; -; mRNA.
DR EMBL; DQ534756; ABF82392.1; -; Genomic_DNA.
DR EMBL; DQ534757; ABF82393.1; -; mRNA.
DR EMBL; AC234644; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH236950; EAL24083.1; -; Genomic_DNA.
DR EMBL; CH471070; EAW83773.1; -; Genomic_DNA.
DR CCDS; CCDS5825.1; -.
DR RefSeq; NP_619638.2; NM_138693.3.
DR AlphaFoldDB; Q8TD94; -.
DR SMR; Q8TD94; -.
DR STRING; 9606.ENSP00000463287; -.
DR iPTMnet; Q8TD94; -.
DR PhosphoSitePlus; Q8TD94; -.
DR BioMuta; KLF14; -.
DR DMDM; 32129442; -.
DR jPOST; Q8TD94; -.
DR MassIVE; Q8TD94; -.
DR PaxDb; Q8TD94; -.
DR PeptideAtlas; Q8TD94; -.
DR PRIDE; Q8TD94; -.
DR ProteomicsDB; 74254; -.
DR Antibodypedia; 73306; 82 antibodies from 16 providers.
DR DNASU; 136259; -.
DR Ensembl; ENST00000583337.4; ENSP00000463287.1; ENSG00000266265.4.
DR GeneID; 136259; -.
DR KEGG; hsa:136259; -.
DR MANE-Select; ENST00000583337.4; ENSP00000463287.1; NM_138693.4; NP_619638.2.
DR CTD; 136259; -.
DR DisGeNET; 136259; -.
DR GeneCards; KLF14; -.
DR HGNC; HGNC:23025; KLF14.
DR HPA; ENSG00000266265; Tissue enhanced (adrenal gland, testis).
DR MIM; 609393; gene.
DR neXtProt; NX_Q8TD94; -.
DR OpenTargets; ENSG00000266265; -.
DR PharmGKB; PA134868089; -.
DR VEuPathDB; HostDB:ENSG00000266265; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163415; -.
DR InParanoid; Q8TD94; -.
DR OMA; WENSGEA; -.
DR OrthoDB; 1308225at2759; -.
DR PhylomeDB; Q8TD94; -.
DR TreeFam; TF351003; -.
DR PathwayCommons; Q8TD94; -.
DR SIGNOR; Q8TD94; -.
DR BioGRID-ORCS; 136259; 15 hits in 1082 CRISPR screens.
DR GenomeRNAi; 136259; -.
DR Pharos; Q8TD94; Tbio.
DR PRO; PR:Q8TD94; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q8TD94; protein.
DR Bgee; ENSG00000266265; Expressed in right adrenal gland cortex and 40 other tissues.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:NTNU_SB.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:1902070; P:positive regulation of sphingolipid mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 3.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..323
FT /note="Krueppel-like factor 14"
FT /id="PRO_0000047186"
FT ZN_FING 195..224
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 225..254
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 255..282
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 27..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 94..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 142..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 166..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 279..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..71
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..116
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 279..298
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 300..323
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 173
FT /note="A -> P (in dbSNP:rs35770036)"
FT /id="VAR_052718"
FT CONFLICT 47
FT /note="P -> H (in Ref. 1; AAM08349 and 4; EAL24083/
FT EAW83773)"
FT CONFLICT 47
FT /note="P -> Q (in Ref. 2; ABF82392/ABF82393)"
FT /evidence="ECO:0000305"
FT CONFLICT 58
FT /note="P -> S (in Ref. 1; AAM08349, 2; ABF82392/ABF82393
FT and 4; EAL24083/EAW83773)"
SQ SEQUENCE 323 AA; 33094 MW; D77A87CA6C61C4B3 CRC64;
MSAAVACLDY FAAECLVSMS AGAVVHRRPP DPEGAGGAAG SEVGAAPPES ALPGPGPPGP
ASVPQLPQVP APSPGAGGAA PHLLAASVWA DLRGSSGEGS WENSGEAPRA SSGFSDPIPC
SVQTPCSELA PASGAAAVCA PESSSDAPAV PSAPAAPGAP AASGGFSGGA LGAGPAPAAD
QAPRRRSVTP AAKRHQCPFP GCTKAYYKSS HLKSHQRTHT GERPFSCDWL DCDKKFTRSD
ELARHYRTHT GEKRFSCPLC PKQFSRSDHL TKHARRHPTY HPDMIEYRGR RRTPRIDPPL
TSEVESSASG SGPGPAPSFT TCL
