ID   KLF14_MOUSE             Reviewed;         325 AA.
AC   Q19A41;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Krueppel-like factor 14;
GN   Name=Klf14;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Parker-Katiraee L., Scherer S.W.;
RT   "The centre for applied genomics genome annotation project.";
RL   Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Sp1 C2H2-type zinc-finger protein family.
CC       {ECO:0000305}.
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DR   EMBL; DQ534758; ABF82394.1; -; mRNA.
DR   CCDS; CCDS51744.1; -.
DR   RefSeq; NP_001128565.1; NM_001135093.1.
DR   AlphaFoldDB; Q19A41; -.
DR   SMR; Q19A41; -.
DR   STRING; 10090.ENSMUSP00000099122; -.
DR   PhosphoSitePlus; Q19A41; -.
DR   PaxDb; Q19A41; -.
DR   PRIDE; Q19A41; -.
DR   ProteomicsDB; 264948; -.
DR   Antibodypedia; 73306; 82 antibodies from 16 providers.
DR   Ensembl; ENSMUST00000101589; ENSMUSP00000099122; ENSMUSG00000073209.
DR   GeneID; 619665; -.
DR   KEGG; mmu:619665; -.
DR   UCSC; uc012ejp.1; mouse.
DR   CTD; 136259; -.
DR   MGI; MGI:3577024; Klf14.
DR   VEuPathDB; HostDB:ENSMUSG00000073209; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT00940000163415; -.
DR   HOGENOM; CLU_002678_33_2_1; -.
DR   InParanoid; Q19A41; -.
DR   OMA; GVLWIPP; -.
DR   OrthoDB; 1308225at2759; -.
DR   PhylomeDB; Q19A41; -.
DR   TreeFam; TF351003; -.
DR   BioGRID-ORCS; 619665; 2 hits in 71 CRISPR screens.
DR   ChiTaRS; Sp6; mouse.
DR   PRO; PR:Q19A41; -.
DR   Proteomes; UP000000589; Chromosome 6.
DR   RNAct; Q19A41; protein.
DR   Bgee; ENSMUSG00000073209; Expressed in pituitary gland and 63 other tissues.
DR   Genevisible; Q19A41; MM.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003682; F:chromatin binding; IDA:MGI.
DR   GO; GO:0003677; F:DNA binding; ISS:MGI.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; ISO:MGI.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR   GO; GO:1902070; P:positive regulation of sphingolipid mediated signaling pathway; IMP:MGI.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IGI:MGI.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 2.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   SUPFAM; SSF57667; SSF57667; 2.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..325
FT                   /note="Krueppel-like factor 14"
FT                   /id="PRO_0000294169"
FT   ZN_FING         195..224
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         225..254
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         255..282
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          153..196
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          270..325
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        182..196
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        277..295
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        305..325
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   325 AA;  35091 MW;  5459637FFC0061BE CRC64;
     MSAAVACLDY FAAECLVSMS TRAVLHRRAT DPEGASAAAV SEVGAVSRES AGKGTGSRGV
     LWIPPVLQVP TPSPGEGDGA PHLLAASALA DLSCGAREDF REDSEEAPCA STSCFEPTWC
     SSPTGGSEPT QAFFEDELSD AESSCSDSAI LDAPEASEEP DDSGEVPEGP PGARPAPSTG
     PTYRRRQITP ASKRHQCSFH GCNKAYYKSS HLKSHQRTHT GERPFSCDWL DCDKKFTRSD
     ELARHYRTHT GEKRFSCPLC PKQFSRSDHL TKHARRHPTY HPDMIEYRGR RRTPRPEPPP
     PAMVESSGSD SSSSSGQETS FTACL